PDDB Home 
PDDB focuses on data used in Prion Disease (PD) research. This site provides tools which allow scientists to analyze, store, and share this PD data with other scientists. (More)
Fri, 5 Nov 2010 14:17:39 GMT
The latest PDDB version is now available.
Thu, 29 Jul 2010 09:19:53 GMT
The original PDDB site has been archived and is available at http://archive-prion.systemsbiology.net.
Thu, 17 Jun 2010 10:38:37 GMT
The redesigned PDDB is now available.
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Fri, 5 Nov 2010 14:17:39 GMT
Lee SJ, Desplats P, Sigurdson C, Tsigelny I, Masliah E. Nat Rev Neurol. 2010 Oct 12.
Fri, 5 Nov 2010 14:17:39 GMT
Halfmann R, Lindquist S. Science. 2010 Oct 29;330(6004):629-32.
Thu, 17 Jun 2010 11:21:30 GMT
Dearmond, SJ and Bajsarowicz, K; Mol Neurodegener. 2010 Jan 21
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Fri, 21 Jan 2011 10:09:30 GMT
PLG - a potential drug target in prion diseases
Thu, 17 Jun 2010 11:14:02 GMT
GFAP - glial marker
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The Dynamic PrP replication and accumulation network described in A Systems Approach to Prion Disease is shown below as a slide show. The experimental design for this study is explained in the Prion Mouse Model. Hypothetical networks of proteins and metabolites that are potentially involved in PrP replication and accumulation were constructed starting from a list of 333 shared DEGs (differentially expressed genes between prion-infected mouse brains and control brains) and protein-protein interaction/metabolic pathway information from public databases. Relative changes of the transcripts for the corresponding proteins are represented in color changes: red-upregulation, green-downregulation, yellow-no change. Data for the transcriptional changes are from BL6 mice infected with RML prions, at 6 weeks, 10 weeks, 14 weeks, 18 weeks, 20 weeks, and 22 weeks after inoculation. The slide show displays the network at these particular timepoints. See Figure 4 in A Systems Approach to Prion Disease for additional details.

Click here to see all six timepoints in a new window.

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Site Developed By:

Institute for Systems Biology      McLaughlin Research Institute

Funded By:

National Institutes of Health      Department of Defense CDMRP

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How to cite PDDB: If you use PDDB in your work and/or publication(s), please cite : The Prion Disease Database: A Comprehensive Transcriptome Resource for Systems Biology Research in Prion Diseases. Gehlenborg, N. et al; Database(2009);2009:bap011. PMID: 20157484.