JUN

Sections: Summary - Genome Browser - Gene Models - Protein Models - Tissue Expression - Interactions - Cross-Reference to Pathways, GO Terms, and Diseases - Publications - External Links

Summary from PDDB Top Help

Gene Description:

jun proto-oncogene; Jun oncogene

Synonyms:

c-jun, AP-1, JUN, c-Jun, AP1, Junc, Jun

Orthologs:

Human JUN, Mouse Jun, Rat Jun

Sources

Genome Browser from PDDB Top Help

Human:	chr1:59019048..59022587
Mouse:	chr4:94715725..94718913
Rat:	chr5:115358166..115361259

Gene Models Top Help

Human Gene Models: 6 (including a summary, and a consensus model)

Mouse Gene Models: 6 (including a summary, and a consensus model)

Rat Gene Models: 3 (including a summary)

Protein Models Top Help

We do not currently have any protein models for JUN.

Tissue Expression Top Help

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions from PDDB Top Help

Network Visualizer for JUN (beta):

Cytoscape: View the JUN interactions in Cytoscape

Interactions Table for JUN:

Cross-Reference to Pathways, GO Terms, and Diseases Top Help

View all

KEGG Network: 15

Biocarta: 40

Agrin in Postsynaptic Differentiation	Human	Mouse
Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling	Human	Mouse
ATM Signaling Pathway	Human	Mouse
BCR Signaling Pathway	Human	Mouse
Cadmium induces DNA synthesis and proliferation in macrophages	Human	Mouse
D4-GDI Signaling Pathway	Human	Mouse
EGF Signaling Pathway	Human	Mouse
EPO Signaling Pathway	Human	Mouse
FAS signaling pathway ( CD95 )	Human	Mouse
Fc Epsilon Receptor I Signaling in Mast Cells	Human	Mouse
Hypoxia-Inducible Factor in the Cardiovascular System	Human
IGF-1 Signaling Pathway	Human	Mouse
IL 2 signaling pathway	Human	Mouse
IL 6 signaling pathway	Human	Mouse
IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	Human	Mouse
Inhibition of Cellular Proliferation by Gleevec	Human	Mouse
Insulin Signaling Pathway	Human	Mouse
Integrin Signaling Pathway	Human	Mouse
Keratinocyte Differentiation	Human	Mouse
Links between Pyk2 and Map Kinases	Human	Mouse
MAPKinase Signaling Pathway	Human	Mouse
Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)	Human
METS affect on Macrophage Differentiation	Human	Mouse
Nerve growth factor pathway (NGF)	Human	Mouse
Oxidative Stress Induced Gene Expression Via Nrf2	Human	Mouse
PDGF Signaling Pathway	Human	Mouse
Pertussis toxin-insensitive CCR5 Signaling in Macrophage	Human	Mouse
Repression of Pain Sensation by the Transcriptional Regulator DREAM	Human	Mouse
Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy	Human	Mouse
Signal transduction through IL1R	Human	Mouse
Signaling of Hepatocyte Growth Factor Receptor	Human	Mouse
Signaling Pathway from G-Protein Families	Human	Mouse
T Cell Receptor Signaling Pathway	Human	Mouse
The 4-1BB-dependent immune response	Human	Mouse
The information-processing pathway at the IFN-beta enhancer	Human	Mouse
TNF/Stress Related Signaling	Human	Mouse
TNFR1 Signaling Pathway	Human	Mouse
Toll-Like Receptor Pathway	Human	Mouse
TPO Signaling Pathway	Human	Mouse
TSP-1 Induced Apoptosis in Microvascular Endothelial Cell	Human	Mouse

Reactome: 8

NCI-Nature Pathway Interaction Database: 39

Gene Ontology: 51

Nuclear chromosome	GO:0000228
Nuclear chromatin	GO:0000790
Angiogenesis	GO:0001525
Release of cytochrome c from mitochondria	GO:0001836
DNA binding	GO:0003677
Double-stranded DNA binding	GO:0003690
Sequence-specific DNA binding transcription factor activity	GO:0003700
RNA polymerase II transcription factor activity	GO:0003702
RNA polymerase II transcription factor activity, enhancer binding	GO:0003705
Transcription coactivator activity	GO:0003713
Rho GTPase activator activity	GO:0005100
Protein binding	GO:0005515
Nucleus	GO:0005634
Nucleoplasm	GO:0005654
Transcription factor complex	GO:0005667
Cytosol	GO:0005829
Regulation of transcription, DNA-dependent	GO:0006355
Transforming growth factor beta receptor signaling pathway	GO:0007179
SMAD protein nuclear translocation	GO:0007184
Aging	GO:0007568
Learning	GO:0007612
Circadian rhythm	GO:0007623
Transcription factor binding	GO:0008134
Negative regulation of cell proliferation	GO:0008285
Response to mechanical stimulus	GO:0009612
Cellular process	GO:0009987
Promoter binding	GO:0010843
Response to organic cyclic substance	GO:0014070
Transcription activator activity	GO:0016563
Transcription repressor activity	GO:0016564
Negative regulation of protein amino acid autophosphorylation	GO:0031953
Response to lipopolysaccharide	GO:0032496
Response to cytokine stimulus	GO:0034097
Leading edge cell differentiation	GO:0035026
Response to drug	GO:0042493
Response to hydrogen peroxide	GO:0042542
Negative regulation of DNA binding	GO:0043392
Positive regulation of neuron apoptosis	GO:0043525
Positive regulation by host of viral transcription	GO:0043923
Positive regulation of monocyte differentiation	GO:0045657
Positive regulation of DNA replication	GO:0045740
Positive regulation of transcription	GO:0045941
Positive regulation of transcription from RNA polymerase II promoter	GO:0045944
Protein heterodimerization activity	GO:0046982
Positive regulation of smooth muscle cell proliferation	GO:0048661
Cellular response to potassium ion starvation	GO:0051365
Response to cAMP	GO:0051591
Regulation of cell cycle	GO:0051726
Membrane depolarization	GO:0051899
SMAD protein signal transduction	GO:0060395
R-SMAD binding	GO:0070412

Genetic Association Database: None available

Publications Top Help

Prion Disease Gene Publications: 0

General Gene Publications: 984

Variation at the NFATC2 Locus Increases the Risk of Thiazolidinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, on behalf of the DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
c-Jun N-terminal kinase/c-Jun inhibits fibroblast proliferation by negatively regulating the levels of stathmin/oncoprotein 18.
Yeap YY, Ng IH, Badrian B, Nguyen TV, Yip YY, Dhillon AS, Mutsaers SE, Silke J, Bogoyevitch MA, Ng DC
Biochem J. 2010
PubMed ID: 20594188
Dual roles for MEF2A and MEF2D during human macrophage terminal differentiation and c-Jun expression.
Aude-Garcia C, Collin-Faure V, Bausinger H, Hanau D, Rabilloud T, Lemercier C
Biochem J. 2010
PubMed ID: 20590529
Rac1-mediated mitochondrial H2O2 generation regulates MMP-9 gene expression in macrophages via inhibition of SP-1 and AP-1.
Murthy S, Ryan A, He C, Mallampalli RK, Carter AB
J Biol Chem. 2010
PubMed ID: 20529870
Transcription of the transforming growth factor beta activating integrin beta8 subunit is regulated by SP3, AP-1, and the p38 pathway.
Markovics JA, Araya J, Cambier S, Jablons D, Hill A, Wolters PJ, Nishimura SL
J Biol Chem. 2010
PubMed ID: 20519498
Inhibition of AP-1 by SARI negatively regulates transformation progression mediated by CCN1.
Dash R, Su ZZ, Lee SG, Azab B, Boukerche H, Sarkar D, Fisher PB
Oncogene. 2010
PubMed ID: 20531301
c-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair.
Machida K, Tsukamoto H, Liu JC, Han YP, Govindarajan S, Lai MM, Akira S, Ou JH
Hepatology. 2010
PubMed ID: 20683948
The C-terminal region of human NFATc2 binds cJun to synergistically activate interleukin-2 transcription.
Nguyen TN, Kim LJ, Walters RD, Drullinger LF, Lively TN, Kugel JF, Goodrich JA
Mol Immunol. 2010
PubMed ID: 20557936
AP-1 overexpression impairs corticosteroid inhibition of collagen production by fibroblasts isolated from asthmatic subjects.
Jacques E, Semlali A, Boulet LP, Chakir J
Am J Physiol Lung Cell Mol Physiol. 2010
PubMed ID: 20543003
Bag1-L is a phosphorylation-dependent coactivator of c-Jun during neuronal apoptosis.
Da Costa CR, Villadiego J, Sancho R, Fontana X, Packham G, Nateri AS, Behrens A
Mol Cell Biol. 2010
PubMed ID: 20516211
Interleukin-1beta induces ICAM-1 expression enhancing leukocyte adhesion in human rheumatoid arthritis synovial fibroblasts: involvement of ERK, JNK, AP-1, and NF-kappaB.
Yang CM, Luo SF, Hsieh HL, Chi PL, Lin CC, Wu CC, Hsiao LD
J Cell Physiol. 2010
PubMed ID: 20432452
EV71 induces COX-2 expression via c-Src/PDGFR/PI3K/Akt/p42/p44 MAPK/AP-1 and NF-kappaB in rat brain astrocytes.
Tung WH, Lee IT, Hsieh HL, Yang CM
J Cell Physiol. 2010
PubMed ID: 20333648
Low doses of lipopolysaccharide and minimally oxidized low-density lipoprotein cooperatively activate macrophages via nuclear factor kappa B and activator protein-1: possible mechanism for acceleration of atherosclerosis by subclinical endotoxemia.
Wiesner P, Choi SH, Almazan F, Benner C, Huang W, Diehl CJ, Gonen A, Butler S, Witztum JL, Glass CK, Miller YI
Circ Res. 2010
PubMed ID: 20489162
CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosis.
Cazanave SC, Elmi NA, Akazawa Y, Bronk SF, Mott JL, Gores GJ
Am J Physiol Gastrointest Liver Physiol. 2010
PubMed ID: 20430872
Expression of MAP3 kinase COT1 is up-regulated by 1,25-dihydroxyvitamin D3 in parallel with activated c-jun during differentiation of human myeloid leukemia cells.
Wang X, Studzinski GP
J Steroid Biochem Mol Biol. 2010
PubMed ID: 20227498
Regulation of CCN2/connective tissue growth factor expression in the nucleus pulposus of the intervertebral disc: role of Smad and activator protein 1 signaling.
Tran CM, Markova D, Smith HE, Susarla B, Ponnappan RK, Anderson DG, Symes A, Shapiro IM, Risbud MV
Arthritis Rheum. 2010
PubMed ID: 20222112
Increase of c-Fos and c-Jun expression in spinal and cranial motoneurons of the degenerating muscle mouse (Scn8a(dmu)).
Ichikawa H, Kano M, Shimizu Y, Suzuki T, Sawada E, Ono W, Chu LW, Côté PD
Cell Mol Neurobiol. 2010
PubMed ID: 20111900
Helicobacter pylori induces ERK-dependent formation of a phospho-c-Fos c-Jun activator protein-1 complex that causes apoptosis in macrophages.
Asim M, Chaturvedi R, Hoge S, Lewis ND, Singh K, Barry DP, Algood HS, de Sablet T, Gobert AP, Wilson KT
J Biol Chem. 2010
PubMed ID: 20410304
Protein kinase C epsilon regulation of translocator protein (18 kDa) Tspo gene expression is mediated through a MAPK pathway targeting STAT3 and c-Jun transcription factors.
Batarseh A, Li J, Papadopoulos V
Biochemistry. 2010
PubMed ID: 20469933
Genetic evidence that SOST inhibits WNT signaling in the limb.
Collette NM, Genetos DC, Murugesh D, Harland RM, Loots GG
Dev Biol. 2010
PubMed ID: 20359476
Activation of AP-1 transcription factors differentiates FGF2 and vascular endothelial growth factor regulation of endothelial nitric-oxide synthase expression in placental artery endothelial cells.
Mata-Greenwood E, Liao WX, Wang W, Zheng J, Chen DB
J Biol Chem. 2010
PubMed ID: 20371606
Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.
Schuurhof A, Bont L, Siezen CL, Hodemaekers H, van Houwelingen HC, Kimman TG, Hoebee B, Kimpen JL, Janssen R
Pediatr Pulmonol. 2010
PubMed ID: 20503287
Mycobacterium tuberculosis upregulates microglial matrix metalloproteinase-1 and -3 expression and secretion via NF-kappaB- and Activator Protein-1-dependent monocyte networks.
Green JA, Elkington PT, Pennington CJ, Roncaroli F, Dholakia S, Moores RC, Bullen A, Porter JC, Agranoff D, Edwards DR, Friedland JS
J Immunol. 2010
PubMed ID: 20483790
ZAK inhibits human lung cancer cell growth via ERK and JNK activation in an AP-1-dependent manner.
Yang JJ, Lee YJ, Hung HH, Tseng WP, Tu CC, Lee H, Wu WJ
Cancer Sci. 2010
PubMed ID: 20331627
SARM inhibits both TRIF- and MyD88-mediated AP-1 activation.
Peng J, Yuan Q, Lin B, Panneerselvam P, Wang X, Luan XL, Lim SK, Leung BP, Ho B, Ding JL
Eur J Immunol. 2010
PubMed ID: 20306472
Apoptosis signal-regulating kinase 1 in peptidoglycan-induced COX-2 expression in macrophages.
Hsu MJ, Chang CK, Chen MC, Chen BC, Ma HP, Hong CY, Lin CH
J Leukoc Biol. 2010
PubMed ID: 20200402
Role of AP-1 and RE-1 binding sites in matrix metalloproteinase-2 transcriptional regulation in skeletal muscle atrophy.
Liu X, Manzano G, Lovett DH, Kim HT
Biochem Biophys Res Commun. 2010
PubMed ID: 20398633
AP-1 (Fra-1/c-Jun)-mediated induction of expression of matrix metalloproteinase-2 is required for 15S-hydroxyeicosatetraenoic acid-induced angiogenesis.
Singh NK, Quyen DV, Kundumani-Sridharan V, Brooks PC, Rao GN
J Biol Chem. 2010
PubMed ID: 20353950
Sox10 is required for Schwann cell identity and progression beyond the immature Schwann cell stage.
Finzsch M, Schreiner S, Kichko T, Reeh P, Tamm ER, Bösl MR, Meijer D, Wegner M
J Cell Biol. 2010
PubMed ID: 20457761
SAMD4B, a novel SAM-containing protein, inhibits AP-1-, p53- and p21-mediated transcriptional activity.
Luo N, Li G, Li Y, Fan X, Wang Y, Ye X, Mo X, Zhou J, Yuan W, Tan M, Xie H, Ocorr K, Bodmer R, Deng Y, Wu X
BMB Rep. 2010
PubMed ID: 20510020
IL-6 and high glucose synergistically upregulate MMP-1 expression by U937 mononuclear phagocytes via ERK1/2 and JNK pathways and c-Jun.
Li Y, Samuvel DJ, Sundararaj KP, Lopes-Virella MF, Huang Y
J Cell Biochem. 2010
PubMed ID: 20225236
Microtubule stabilization by bone morphogenetic protein receptor-mediated scaffolding of c-Jun N-terminal kinase promotes dendrite formation.
Podkowa M, Zhao X, Chow CW, Coffey ET, Davis RJ, Attisano L
Mol Cell Biol. 2010
PubMed ID: 20176805
Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.
Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P
Dev Cell. 2010
PubMed ID: 20412781
Human TMEM174 that is highly expressed in kidney tissue activates AP-1 and promotes cell proliferation.
Wang P, Sun B, Hao D, Zhang X, Shi T, Ma D
Biochem Biophys Res Commun. 2010
PubMed ID: 20331980
Dissecting the role of leucine zippers in the binding of bZIP domains of Jun transcription factor to DNA.
Seldeen KL, McDonald CB, Deegan BJ, Bhat V, Farooq A
Biochem Biophys Res Commun. 2010
PubMed ID: 20331972
Extracellular signal-regulated kinase 8-mediated c-Jun phosphorylation increases tumorigenesis of human colon cancer.
Xu YM, Zhu F, Cho YY, Carper A, Peng C, Zheng D, Yao K, Lau AT, Zykova TA, Kim HG, Bode AM, Dong Z
Cancer Res. 2010
PubMed ID: 20395206
Inhibiting TRAF2-mediated activation of NF-kappaB facilitates induction of AP-1.
Manna SK, Babajan B, Raghavendra PB, Raviprakash N, Sureshkumar C
J Biol Chem. 2010
PubMed ID: 20133937
TAF4b and Jun/activating protein-1 collaborate to regulate the expression of integrin alpha6 and cancer cell migration properties.
Kalogeropoulou M, Voulgari A, Kostourou V, Sandaltzopoulos R, Dikstein R, Davidson I, Tora L, Pintzas A
Mol Cancer Res. 2010
PubMed ID: 20353996
Novel function of B cell-activating factor in the induction of IL-10-producing regulatory B cells.
Yang M, Sun L, Wang S, Ko KH, Xu H, Zheng BJ, Cao X, Lu L
J Immunol. 2010
PubMed ID: 20208006
Bile acid regulates MUC2 transcription in colon cancer cells via positive EGFR/PKC/Ras/ERK/CREB, PI3K/Akt/IkappaB/NF-kappaB and p38/MSK1/CREB pathways and negative JNK/c-Jun/AP-1 pathway.
Lee HY, Crawley S, Hokari R, Kwon S, Kim YS
Int J Oncol. 2010
PubMed ID: 20198339
p21(Cip1) up-regulated during histone deacetylase inhibitor-induced CD4(+) T-cell anergy selectively associates with mitogen-activated protein kinases.
Selma Dagtas A, Gilbert KM
Immunology. 2010
PubMed ID: 20102411
Thrombin induces endothelial arginase through AP-1 activation.
Zhu W, Chandrasekharan UM, Bandyopadhyay S, Morris SM, DiCorleto PE, Kashyap VS
Am J Physiol Cell Physiol. 2010
PubMed ID: 20032511
Enteroaggregative Escherichia coli infection induces IL-8 production via activation of mitogen-activated protein kinases and the transcription factors NF-kappaB and AP-1 in INT-407 cells.
Khan K, Konar M, Goyal A, Ghosh S
Mol Cell Biochem. 2010
PubMed ID: 19898747
c-Jun-NH2 terminal kinase (JNK)-mediates AP-1 activation by thioredoxin: phosphorylation of cJun, JunB, and Fra-1.
Das KC, Muniyappa H
Mol Cell Biochem. 2010
PubMed ID: 19859790
Lithocholic acid upregulates uPAR and cell invasiveness via MAPK and AP-1 signaling in colon cancer cells.
Baek MK, Park JS, Park JH, Kim MH, Kim HD, Bae WK, Chung IJ, Shin BA, Jung YD
Cancer Lett. 2010
PubMed ID: 19782465
Involvement of Ras and AP-1 in Helicobacter pylori-induced expression of COX-2 and iNOS in gastric epithelial AGS cells.
Cho SO, Lim JW, Kim KH, Kim H
Dig Dis Sci. 2010
PubMed ID: 19495976
Expression of a homeostatic regulator, Wip1 (wild-type p53-induced phosphatase), is temporally induced by c-Jun and p53 in response to UV irradiation.
Song JY, Han HS, Sabapathy K, Lee BM, Yu E, Choi J
J Biol Chem. 2010
PubMed ID: 20093361
The antiapoptotic DeltaNp73 is degraded in a c-Jun-dependent manner upon genotoxic stress through the antizyme-mediated pathway.
Dulloo I, Gopalan G, Melino G, Sabapathy K
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20185758
Induction of c-Jun phosphorylation in spinal motoneurons in neonatal and adult rats following axonal injury.
Yuan Q, Hu B, Wu Y, Chu TH, Su H, Zhang W, So KF, Lin Z, Wu W
Brain Res. 2010
PubMed ID: 20096669
c-Jun induces mammary epithelial cellular invasion and breast cancer stem cell expansion.
Jiao X, Katiyar S, Willmarth NE, Liu M, Ma X, Flomenberg N, Lisanti MP, Pestell RG
J Biol Chem. 2010
PubMed ID: 20053993
An atlas of combinatorial transcriptional regulation in mouse and man.
Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegnér J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y
Cell. 2010
PubMed ID: 20211142
SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages.
Zhang R, Chen HZ, Liu JJ, Jia YY, Zhang ZQ, Yang RF, Zhang Y, Xu J, Wei YS, Liu DP, Liang CC
J Biol Chem. 2010
PubMed ID: 20042607
Up-regulation of TRPM6 transcriptional activity by AP-1 in renal epithelial cells.
Ikari A, Sanada A, Okude C, Sawada H, Yamazaki Y, Sugatani J, Miwa M
J Cell Physiol. 2010
PubMed ID: 19937979
Heterodimerization with different Jun proteins controls c-Fos intranuclear dynamics and distribution.
Malnou CE, Brockly F, Favard C, Moquet-Torcy G, Piechaczyk M, Jariel-Encontre I
J Biol Chem. 2010
PubMed ID: 20053986
Ran overexpression leads to diminished T cell responses and selectively modulates nuclear levels of c-Jun and c-Fos.
Qiao X, Pham DN, Luo H, Wu J
J Biol Chem. 2010
PubMed ID: 20028981
Stability and DNA-binding ability of the bZIP dimers formed by the ATF-2 and c-Jun transcription factors.
Carrillo RJ, Dragan AI, Privalov PL
J Mol Biol. 2010
PubMed ID: 19944700
Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling.
Hu M, Sun XJ, Zhang YL, Kuang Y, Hu CQ, Wu WL, Shen SH, Du TT, Li H, He F, Xiao HS, Wang ZG, Liu TX, Lu H, Huang QH, Chen SJ, Chen Z
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20133625
Transactivation and expression patterns of Jun and Fos/AP-1 super-family proteins in human oral cancer.
Mishra A, Bharti AC, Saluja D, Das BC
Int J Cancer. 2010
PubMed ID: 19653276
Mitogenic regulation of p27(Kip1) gene is mediated by AP-1 transcription factors.
Khattar E, Kumar V
J Biol Chem. 2010
PubMed ID: 19959471
A novel subtype of AP-1-binding motif within the palmitoylated trans-Golgi network/endosomal accessory protein Gadkin/gamma-BAR.
Maritzen T, Schmidt MR, Kukhtina V, Higman VA, Strauss H, Volkmer R, Oschkinat H, Dotti CG, Haucke V
J Biol Chem. 2010
PubMed ID: 19965873
[Expression of c-jun protein after experimental rat brain concussion]
Wang F, Li YH
Fa Yi Xue Za Zhi. 2010
PubMed ID: 20232736
beta-Adrenergic receptor stimulated Ncx1 upregulation is mediated via a CaMKII/AP-1 signaling pathway in adult cardiomyocytes.
Mani SK, Egan EA, Addy BK, Grimm M, Kasiganesan H, Thiyagarajan T, Renaud L, Brown JH, Kern CB, Menick DR
J Mol Cell Cardiol. 2010
PubMed ID: 19945464
Tpl2/AP-1 enhances murine gammaherpesvirus 68 lytic replication.
Li X, Feng J, Chen S, Peng L, He WW, Qi J, Deng H, Sun R
J Virol. 2010
PubMed ID: 19939924
Dihydro-N-caffeoyltyramine down-regulates cyclooxygenase-2 expression by inhibiting the activities of C/EBP and AP-1 transcription factors.
Han EH, Kim JY, Kim HG, Choi JH, Im JH, Woo ER, Jeong HG
Food Chem Toxicol. 2010
PubMed ID: 19922759
Tyrosine 170 is dispensable for c-Jun turnover.
Xie M, Sabapathy K
Cell Signal. 2010
PubMed ID: 19818398
The SWI/SNF chromatin-remodeling complex modulates peripheral T cell activation and proliferation by controlling AP-1 expression.
Jeong SM, Lee C, Lee SK, Kim J, Seong RH
J Biol Chem. 2010
PubMed ID: 19910461
c-Jun regulates phosphoinositide-dependent kinase 1 transcription: implication for Akt and protein kinase C activities and melanoma tumorigenesis.
Lopez-Bergami P, Kim H, Dewing A, Goydos J, Aaronson S, Ronai Z
J Biol Chem. 2010
PubMed ID: 19910471
Identification of early growth response protein 1 (EGR-1) as a novel target for JUN-induced apoptosis in multiple myeloma.
Chen L, Wang S, Zhou Y, Wu X, Entin I, Epstein J, Yaccoby S, Xiong W, Barlogie B, Shaughnessy JD, Zhan F
Blood. 2010
PubMed ID: 19837979
Frat oncoproteins act at the crossroad of canonical and noncanonical Wnt-signaling pathways.
van Amerongen R, Nawijn MC, Lambooij JP, Proost N, Jonkers J, Berns A
Oncogene. 2010
PubMed ID: 19802005
Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".
Johnatty SE, Beesley J, Chen X, Macgregor S, Duffy DL, Spurdle AB, deFazio A, Gava N, Webb PM, Rossing MA, Doherty JA, Goodman MT, Lurie G, Thompson PJ, Wilkens LR, Ness RB, Moysich KB, Chang-Claude J, Wang-Gohrke S, Cramer DW, Terry KL, Hankinson SE, Tworoger SS, Garcia-Closas M, Yang H, Lissowska J, Chanock SJ, Pharoah PD, Song H, Whitemore AS, Pearce CL, Stram DO, Wu AH, Pike MC, Gayther SA, Ramus SJ, Menon U, Gentry-Maharaj A, Anton-Culver H, Ziogas A, Hogdall E, Kjaer SK, Hogdall C, Berchuck A, Schildkraut JM, Iversen ES, Moorman PG, Phelan CM, Sellers TA, Cunningham JM, Vierkant RA, Rider DN, Goode EL, Haviv I, Chenevix-Trench G, Ovarian Cancer Association Consortium, Australian Ovarian Cancer Study Group, Australian Cancer Study (Ovarian Cancer)
PLoS Genet. 2010
PubMed ID: 20628624
Differential cytokine regulation by NF-kappaB and AP-1 in Jurkat T-cells.
Khalaf H, Jass J, Olsson PE
BMC Immunol. 2010
PubMed ID: 20507572
The leucine zipper domains of the transcription factors GCN4 and c-Jun have ribonuclease activity.
Nikolaev Y, Deillon C, Hoffmann SR, Bigler L, Friess S, Zenobi R, Pervushin K, Hunziker P, Gutte B
PLoS One. 2010
PubMed ID: 20505831
BEX2 has a functional interplay with c-Jun/JNK and p65/RelA in breast cancer.
Naderi A, Liu J, Hughes-Davies L
Mol Cancer. 2010
PubMed ID: 20482821
Functional crosstalk between type I and II interferon through the regulated expression of STAT1.
Gough DJ, Messina NL, Hii L, Gould JA, Sabapathy K, Robertson AP, Trapani JA, Levy DE, Hertzog PJ, Clarke CJ, Johnstone RW
PLoS Biol. 2010
PubMed ID: 20436908
Differential requirement of the epidermal growth factor receptor for G protein-mediated activation of transcription factors by lysophosphatidic acid.
Oyesanya RA, Greenbaum S, Dang D, Lee Z, Mukherjee A, Wu J, Dent P, Fang X
Mol Cancer. 2010
PubMed ID: 20074357
Possible involvements of nuclear factor-kappa B and activator protein-1 in the tumor necrosis factor-alpha-induced upregulation of matrix metalloproteinase-12 in human alveolar epithelial A549 cell line.
Yu Y, Chiba Y, Sakai H, Misawa M
J Pharmacol Sci. 2010
PubMed ID: 20051654
Inhibition of AP-1 and MAPK signaling and activation of Nrf2/ARE pathway by quercitrin.
Ding M, Zhao J, Bowman L, Lu Y, Shi X
Int J Oncol. 2010
PubMed ID: 19956833
AP-1 inhibitory peptides are neuroprotective following acute glutamate excitotoxicity in primary cortical neuronal cultures.
Meade AJ, Meloni BP, Cross J, Bakker AJ, Fear MW, Mastaglia FL, Watt PM, Knuckey NW
J Neurochem. 2010
PubMed ID: 19878434
The potential role of c-Jun activation in patients with cutaneous lichen planus.
Marceková Z, Flaig MJ, Kekus M, Ruzicka T, Rupec RA
Exp Dermatol. 2010
PubMed ID: 19758340
Activation of JNK and c-Jun is involved in glucose oxidase-mediated cell death of human lymphoma cells.
Son YO, Jang YS, Shi X, Lee JC
Mol Cells. 2009
PubMed ID: 19937141
DNA plasticity is a key determinant of the energetics of binding of Jun-Fos heterodimeric transcription factor to genetic variants of TGACGTCA motif.
Seldeen KL, McDonald CB, Deegan BJ, Bhat V, Farooq A
Biochemistry. 2009
PubMed ID: 19921846
Systemic anti-VEGF treatment strongly reduces skin inflammation in a mouse model of psoriasis.
Schonthaler HB, Huggenberger R, Wculek SK, Detmar M, Wagner EF
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19995970
Quantitative AP-1 gene regulation by oxidative stress in the human retinal pigment epithelium.
Chaum E, Yin J, Yang H, Thomas F, Lang JC
J Cell Biochem. 2009
PubMed ID: 19795388
[Effect of ERK/AP-1 signaling pathway on proliferation of hepatoma cells induced by PAR-2 agonists]
Zheng YM, Xie LQ, Li X, Zhao JY, Chen XY, Chen L, Zhou J, Li F
Zhonghua Yi Xue Za Zhi. 2009
PubMed ID: 20193273
Infrequent amplification of JUN in hepatocellular carcinoma.
Endo M, Yasui K, Nakajima T, Gen Y, Tsuji K, Dohi O, Zen K, Mitsuyoshi H, Minami M, Itoh Y, Taniwaki M, Tanaka S, Arii S, Okanoue T, Yoshikawa T
Anticancer Res. 2009
PubMed ID: 20044606
Activation of two distinct MAPK pathways governs constitutive expression of matrix metalloproteinase-1 in human pancreatic cancer cell lines.
Endo H, Watanabe T, Sugioka Y, Niioka M, Inagaki Y, Okazaki I
Int J Oncol. 2009
PubMed ID: 19885545
A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.
Need AC, Attix DK, McEvoy JM, Cirulli ET, Linney KL, Hunt P, Ge D, Heinzen EL, Maia JM, Shianna KV, Weale ME, Cherkas LF, Clement G, Spector TD, Gibson G, Goldstein DB
Hum Mol Genet. 2009
PubMed ID: 19734545
Fra-1/AP-1 impairs inflammatory responses and chondrogenesis in fracture healing.
Yamaguchi T, Takada Y, Maruyama K, Shimoda K, Arai Y, Nango N, Kosaki N, Takaishi H, Toyama Y, Matsuo K
J Bone Miner Res. 2009
PubMed ID: 19558315
IL-17 stimulates migration of carotid artery vascular smooth muscle cells in an MMP-9 dependent manner via p38 MAPK and ERK1/2-dependent NF-kappaB and AP-1 activation.
Cheng G, Wei L, Xiurong W, Xiangzhen L, Shiguang Z, Songbin F
Cell Mol Neurobiol. 2009
PubMed ID: 19404732
TNFalpha shedding and epidermal inflammation are controlled by Jun proteins.
Guinea-Viniegra J, Zenz R, Scheuch H, Hnisz D, Holcmann M, Bakiri L, Schonthaler HB, Sibilia M, Wagner EF
Genes Dev. 2009
PubMed ID: 19933155
c-Jun, krox-20, and integrin beta4 expression following chronic nerve compression injury.
Pham K, Nassiri N, Gupta R
Neurosci Lett. 2009
PubMed ID: 19765400
Chronic oxidative stress sensitizes hepatocytes to death from 4-hydroxynonenal by JNK/c-Jun overactivation.
Singh R, Wang Y, Schattenberg JM, Xiang Y, Czaja MJ
Am J Physiol Gastrointest Liver Physiol. 2009
PubMed ID: 20501438
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
Ethanol augments RANTES/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappa B, HIF-1 alpha, and AP-1.
Yeligar SM, Machida K, Tsukamoto H, Kalra VK
J Immunol. 2009
PubMed ID: 19828633
C-fos, fos-B, c-jun and dusp-1 expression in the mouse heart after single and repeated methamphetamine administration.
Matsuo A, Ikematsu K, Nakasono I
Leg Med (Tokyo). 2009
PubMed ID: 19828354
BMP7 promotes proliferation of nephron progenitor cells via a JNK-dependent mechanism.
Blank U, Brown A, Adams DC, Karolak MJ, Oxburgh L
Development. 2009
PubMed ID: 19793891
Transcription factor AP-1 promotes growth and radioresistance in prostate cancer cells.
Kajanne R, Miettinen P, Tenhunen M, Leppä S
Int J Oncol. 2009
PubMed ID: 19787273
Angiotensin II stimulates KLF5 phosphorylation and its interaction with c-Jun leading to suppression of p21 expression in vascular smooth muscle cells.
He M, Han M, Zheng B, Shu YN, Wen JK
J Biochem. 2009
PubMed ID: 19628677
Aromatase promoter I.f is regulated by estrogen receptor alpha (ESR1) in mouse hypothalamic neuronal cell lines.
Yilmaz MB, Wolfe A, Cheng YH, Glidewell-Kenney C, Jameson JL, Bulun SE
Biol Reprod. 2009
PubMed ID: 19605792
NAG7 promotes human nasopharyngeal carcinoma invasion through inhibition of estrogen receptor alpha and up-regulation of JNK2/AP-1/MMP1 pathways.
Huang C, Wu M, Tang Y, Li X, Ouyang J, Xiao L, Li D, Li G
J Cell Physiol. 2009
PubMed ID: 19591174
AP-1 and KIF13A coordinate endosomal sorting and positioning during melanosome biogenesis.
Delevoye C, Hurbain I, Tenza D, Sibarita JB, Uzan-Gafsou S, Ohno H, Geerts WJ, Verkleij AJ, Salamero J, Marks MS, Raposo G
J Cell Biol. 2009
PubMed ID: 19841138
Basic fibroblast growth factor upregulates adrenomedullin expression in ovarian epithelial carcinoma cells via JNK-AP-1 pathway.
Zhang Y, Zhang S, Shang H, Pang X, Zhao Y
Regul Pept. 2009
PubMed ID: 19616043
Regulation of inflammatory cytokine expression in pulmonary epithelial cells by pre-B-cell colony-enhancing factor via a nonenzymatic and AP-1-dependent mechanism.
Liu P, Li H, Cepeda J, Xia Y, Kempf JA, Ye H, Zhang LQ, Ye SQ
J Biol Chem. 2009
PubMed ID: 19654329
Hypoxia-induced decrease in p53 protein level and increase in c-jun DNA binding activity results in cancer cell resistance to etoposide.
Cosse JP, Ronvaux M, Ninane N, Raes MJ, Michiels C
Neoplasia. 2009
PubMed ID: 19794957
Akt-dependent Pp2a activity is required for epidermal barrier formation during late embryonic development.
O'Shaughnessy RF, Welti JC, Sully K, Byrne C
Development. 2009
PubMed ID: 19762425
c-jun controls the ability of IL-12 to induce IL-10 production from human memory CD4+ T cells.
Garcia CA, Wang H, Benakanakere MR, Barrett E, Kinane DF, Martin M
J Immunol. 2009
PubMed ID: 19734233
Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation.
Martinez G, Wijesinghe M, Turner K, Abud HE, Taketo MM, Noda T, Robinson ML, de Iongh RU
Invest Ophthalmol Vis Sci. 2009
PubMed ID: 19515997
AP-1 activated by toll-like receptors regulates expression of IL-23 p19.
Liu W, Ouyang X, Yang J, Liu J, Li Q, Gu Y, Fukata M, Lin T, He JC, Abreu M, Unkeless JC, Mayer L, Xiong H
J Biol Chem. 2009
PubMed ID: 19592489
[Expression of AP-1 and TGF-beta1 in kidney of iodine deficient rats and its significance]
Dai YH, Zhang J, Liu CJ, Fang H
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009
PubMed ID: 19737467
Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak.
Suriben R, Kivimäe S, Fisher DA, Moon RT, Cheyette BN
Nat Genet. 2009
PubMed ID: 19701191
The BH3-only protein bid does not mediate death-receptor-induced liver injury in obstructive cholestasis.
Nalapareddy P, Schüngel S, Hong JY, Manns MP, Jaeschke H, Vogel A
Am J Pathol. 2009
PubMed ID: 19661444
Propensity for HBZ-SP1 isoform of HTLV-I to inhibit c-Jun activity correlates with sequestration of c-Jun into nuclear bodies rather than inhibition of its DNA-binding activity.
Clerc I, Hivin P, Rubbo PA, Lemasson I, Barbeau B, Mesnard JM
Virology. 2009
PubMed ID: 19595408
A dual role of the N-terminal FQQI motif in GLUT4 trafficking.
Bernhardt U, Carlotti F, Hoeben RC, Joost HG, Al-Hasani H
Biol Chem. 2009
PubMed ID: 19558319
The immediate-early oncoproteins Fra-1, c-Fos, and c-Jun have distinguishable surface behavior and interactions with phospholipids.
Gaggiotti MC, Del Boca M, Castro G, Caputto BL, Borioli GA
Biopolymers. 2009
PubMed ID: 19384981
BCR-ABL promotes neutrophil differentiation in the chronic phase of chronic myeloid leukemia by downregulating c-Jun expression.
Kobayashi S, Kimura F, Ikeda T, Osawa Y, Torikai H, Kobayashi A, Sato K, Motoyoshi K
Leukemia. 2009
PubMed ID: 19357699
Effect of ultraviolet B radiation on activator protein 1 constituent proteins and modulation by dietary energy restriction in SKH-1 mouse skin.
Hopper BD, Przybyszewski J, Chen HW, Hammer KD, Birt DF
Mol Carcinog. 2009
PubMed ID: 19263438
Identification of GATA2 and AP-1 Activator elements within the enhancer VNTR occurring in intron 5 of the human SIRT3 gene.
Bellizzi D, Covello G, Di Cianni F, Tong Q, De Benedictis G
Mol Cells. 2009
PubMed ID: 19714312
Embryonic arrest at midgestation and disruption of Notch signaling produced by the absence of both epsin 1 and epsin 2 in mice.
Chen H, Ko G, Zatti A, Di Giacomo G, Liu L, Raiteri E, Perucco E, Collesi C, Min W, Zeiss C, De Camilli P, Cremona O
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19666558
cAMP stringently regulates human cathelicidin antimicrobial peptide expression in the mucosal epithelial cells by activating cAMP-response element-binding protein, AP-1, and inducible cAMP early repressor.
Chakraborty K, Maity PC, Sil AK, Takeda Y, Das S
J Biol Chem. 2009
PubMed ID: 19531482
TNF-alpha induces TGF-beta1 expression in lung fibroblasts at the transcriptional level via AP-1 activation.
Sullivan DE, Ferris M, Nguyen H, Abboud E, Brody AR
J Cell Mol Med. 2009
PubMed ID: 20141610
Activator protein-1 mediates docosahexaenoic acid-induced apoptosis of human gastric cancer cells.
Lee SE, Lim JW, Kim H
Ann N Y Acad Sci. 2009
PubMed ID: 19723051
Increased c-Jun expression and reduced GATA2 expression promote aberrant monocytic differentiation induced by activating PTPN11 mutants.
Yang Z, Kondo T, Voorhorst CS, Nabinger SC, Ndong L, Yin F, Chan EM, Yu M, Würstlin O, Kratz CP, Niemeyer CM, Flotho C, Hashino E, Chan RJ
Mol Cell Biol. 2009
PubMed ID: 19528235
Nuclear localization of c-FLIP-L and its regulation of AP-1 activity.
Zhang J, Chen Y, Huang Q, Cheng W, Kang Y, Shu L, Yin W, Hua ZC
Int J Biochem Cell Biol. 2009
PubMed ID: 19433309
Decursin and decursinol inhibit VEGF-induced angiogenesis by blocking the activation of extracellular signal-regulated kinase and c-Jun N-terminal kinase.
Son SH, Kim MJ, Chung WY, Son JA, Kim YS, Kim YC, Kang SS, Lee SK, Park KK
Cancer Lett. 2009
PubMed ID: 19307054
Protein kinase A-regulated assembly of a MEF2{middle dot}HDAC4 repressor complex controls c-Jun expression in vascular smooth muscle cells.
Gordon JW, Pagiatakis C, Salma J, Du M, Andreucci JJ, Zhao J, Hou G, Perry RL, Dan Q, Courtman D, Bendeck MP, McDermott JC
J Biol Chem. 2009
PubMed ID: 19389706
JNK signalling modulates intestinal homeostasis and tumourigenesis in mice.
Sancho R, Nateri AS, de Vinuesa AG, Aguilera C, Nye E, Spencer-Dene B, Behrens A
EMBO J. 2009
PubMed ID: 19521338
Human ZCCHC12 activates AP-1 and CREB signaling as a transcriptional co-activator.
Li H, Liu Q, Hu X, Feng D, Xiang S, He Z, Hu X, Zhou J, Ding X, Zhou C, Zhang J
Acta Biochim Biophys Sin (Shanghai). 2009
PubMed ID: 19578717
Expression of Jun and Fos proteins in ovarian tumors of different malignant potential and in ovarian cancer cell lines.
Hein S, Mahner S, Kanowski C, Löning T, Jänicke F, Milde-Langosch K
Oncol Rep. 2009
PubMed ID: 19513521
Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development.
Saiga T, Fukuda T, Matsumoto M, Tada H, Okano HJ, Okano H, Nakayama KI
Mol Cell Biol. 2009
PubMed ID: 19398581
Oleic acid-induced ADRP expression requires both AP-1 and PPAR response elements, and is reduced by Pycnogenol through mRNA degradation in NMuLi liver cells.
Fan B, Ikuyama S, Gu JQ, Wei P, Oyama J, Inoguchi T, Nishimura J
Am J Physiol Endocrinol Metab. 2009
PubMed ID: 19383873
Regulation of c-Fos and c-Jun gene expression by phospholipase C activity in adult cardiomyocytes.
Singal T, Dhalla NS, Tappia PS
Mol Cell Biochem. 2009
PubMed ID: 19225867
NGX6 inhibits AP-1 and Ets-1 expression and down-regulates cyclin D1 in human colorectal cancer.
Peng Y, Li H, Wu M, Wang X, Fan S, Liu F, Xiang B, Guo Q, Tang X, Shen S
Acta Biochim Biophys Sin (Shanghai). 2009
PubMed ID: 19499154
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S
Anal Chem. 2009
PubMed ID: 19413330
Exposure to cigarette smoke upregulates AP-1 activity and induces TNF-alpha overexpression in mouse lungs.
Li YT, He B, Wang YZ
Inhal Toxicol. 2009
PubMed ID: 19235541
Dual role of COUP-TF-interacting protein 2 in epidermal homeostasis and permeability barrier formation.
Golonzhka O, Liang X, Messaddeq N, Bornert JM, Campbell AL, Metzger D, Chambon P, Ganguli-Indra G, Leid M, Indra AK
J Invest Dermatol. 2009
PubMed ID: 19092943
Clinorotation upregulates inducible nitric oxide synthase by inhibiting AP-1 activation in human umbilical vein endothelial cells.
Wang YC, Zhang S, Du TY, Wang B, Sun XQ
J Cell Biochem. 2009
PubMed ID: 19306295
Activator protein 1 shows a biphasic induction and transcriptional activity after low dose X-irradiation in EA.hy.926 endothelial cells.
Rödel F, Keilholz L, Herrmann M, Weiss C, Frey B, Voll R, Gaipl U, Rödel C
Autoimmunity. 2009
PubMed ID: 19811296
[Effects of hydroxyethyl starch 130/0.4 on P38 mitogen-activated protein kinases signal transduction pathway]
Wang YX, Gao Y, Tian J, Li WW, Wang XR
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2009
PubMed ID: 19439112
Activator protein-1 has an essential role in pancreatic cancer cells and is regulated by a novel Akt-mediated mechanism.
Shin S, Asano T, Yao Y, Zhang R, Claret FX, Korc M, Sabapathy K, Menter DG, Abbruzzese JL, Reddy SA
Mol Cancer Res. 2009
PubMed ID: 19435822
FGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fate.
Huang J, Dattilo LK, Rajagopal R, Liu Y, Kaartinen V, Mishina Y, Deng CX, Umans L, Zwijsen A, Roberts AB, Beebe DC
Development. 2009
PubMed ID: 19369394
Opposing roles for ATF2 and c-Fos in c-Jun-mediated neuronal apoptosis.
Yuan Z, Gong S, Luo J, Zheng Z, Song B, Ma S, Guo J, Hu C, Thiel G, Vinson C, Hu CD, Wang Y, Li M
Mol Cell Biol. 2009
PubMed ID: 19255142
Lipopolysaccharide-dependent interaction between PU.1 and c-Jun determines production of lipocalin-type prostaglandin D synthase and prostaglandin D2 in macrophages.
Joo M, Kwon M, Cho YJ, Hu N, Pedchenko TV, Sadikot RT, Blackwell TS, Christman JW
Am J Physiol Lung Cell Mol Physiol. 2009
PubMed ID: 19181746
Liver NF-kappaB and AP-1 DNA binding in obese patients.
Videla LA, Tapia G, Rodrigo R, Pettinelli P, Haim D, Santibañez C, Araya AV, Smok G, Csendes A, Gutierrez L, Rojas J, Castillo J, Korn O, Maluenda F, Díaz JC, Rencoret G, Poniachik J
Obesity (Silver Spring). 2009
PubMed ID: 19165171
AP-1-controlled hepatocyte growth factor activation promotes keratinocyte migration via CEACAM1 and urokinase plasminogen activator/urokinase plasminogen receptor.
Schnickmann S, Camacho-Trullio D, Bissinger M, Eils R, Angel P, Schirmacher P, Szabowski A, Breuhahn K
J Invest Dermatol. 2009
PubMed ID: 19020551
Mechanical force induces type I collagen expression in human periodontal ligament fibroblasts through activation of ERK/JNK and AP-1.
Kook SH, Hwang JM, Park JS, Kim EM, Heo JS, Jeon YM, Lee JC
J Cell Biochem. 2009
PubMed ID: 19206162
Repression of NF-kappaB and activation of AP-1 enhance apoptosis in prostate cancer cells.
Zhang X, Huang X, Olumi AF
Int J Cancer. 2009
PubMed ID: 19123467
Viperin is required for optimal Th2 responses and T-cell receptor-mediated activation of NF-kappaB and AP-1.
Qiu LQ, Cresswell P, Chin KC
Blood. 2009
PubMed ID: 19047684
Cooperation between GLI and JUN enhances transcription of JUN and selected GLI target genes.
Laner-Plamberger S, Kaser A, Paulischta M, Hauser-Kronberger C, Eichberger T, Frischauf AM
Oncogene. 2009
PubMed ID: 19219074
Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.
Siezen CL, Bont L, Hodemaekers HM, Ermers MJ, Doornbos G, Van't Slot R, Wijmenga C, Houwelingen HC, Kimpen JL, Kimman TG, Hoebee B, Janssen R
Pediatr Infect Dis J. 2009
PubMed ID: 19258923
Fra-1 negatively regulates lipopolysaccharide-mediated inflammatory responses.
Morishita H, Saito F, Kayama H, Atarashi K, Kuwata H, Yamamoto M, Takeda K
Int Immunol. 2009
PubMed ID: 19251936
Protective roles of hydroxyethyl starch 130/0.4 in intestinal inflammatory response and oxidative stress after hemorrhagic shock and resuscitation in rats.
Wang P, Li Y, Li J
Inflammation. 2009
PubMed ID: 19238531
Cytokine production through PKC/p38 signaling pathways, not through JAK/STAT1 pathway, in mast cells stimulated with IFNgamma.
Seo JY, Kim DY, Lee YS, Ro JY
Cytokine. 2009
PubMed ID: 19231233
Loss of E-cadherin-mediated cell-cell contacts activates a novel mechanism for up-regulation of the proto-oncogene c-Jun.
Knirsh R, Ben-Dror I, Spangler B, Matthews GD, Kuphal S, Bosserhoff AK, Vardimon L
Mol Biol Cell. 2009
PubMed ID: 19193763
Adrenomedullin promotes cell cycle transit and up-regulates cyclin D1 protein level in human glioblastoma cells through the activation of c-Jun/JNK/AP-1 signal transduction pathway.
Ouafik L, Berenguer-Daize C, Berthois Y
Cell Signal. 2009
PubMed ID: 19166930
Identification of a novel human lactate dehydrogenase gene LDHAL6A, which activates transcriptional activities of AP1(PMA).
Chen X, Gu X, Shan Y, Tang W, Yuan J, Zhong Z, Wang Y, Huang W, Wan B, Yu L
Mol Biol Rep. 2009
PubMed ID: 18351441
Phosphorylation of Activation Transcription Factor-2 at Serine 121 by Protein Kinase C Controls c-Jun-mediated Activation of Transcription.
Yamasaki T, Takahashi A, Pan J, Yamaguchi N, Yokoyama KK
J Biol Chem. 2009
PubMed ID: 19176525
Single nucleotide variants of the TGACTCA motif modulate energetics and orientation of binding of the Jun-Fos heterodimeric transcription factor.
Seldeen KL, McDonald CB, Deegan BJ, Farooq A
Biochemistry. 2009
PubMed ID: 19215067
The nuclear receptors SF1 and LRH1 are expressed in endometrial cancer cells and regulate steroidogenic gene transcription by cooperating with AP-1 factors.
Dubé C, Bergeron F, Vaillant MJ, Robert NM, Brousseau C, Tremblay JJ
Cancer Lett. 2009
PubMed ID: 19022561
Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium.
Matsuyama M, Aizawa S, Shimono A
PLoS Genet. 2009
PubMed ID: 19300477
The histamine H4 receptor is functionally expressed on T(H)2 cells.
Gutzmer R, Mommert S, Gschwandtner M, Zwingmann K, Stark H, Werfel T
J Allergy Clin Immunol. 2009
PubMed ID: 19281909
Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease.
Wang K, Zhang H, Kugathasan S, Annese V, Bradfield JP, Russell RK, Sleiman PM, Imielinski M, Glessner J, Hou C, Wilson DC, Walters T, Kim C, Frackelton EC, Lionetti P, Barabino A, Van Limbergen J, Guthery S, Denson L, Piccoli D, Li M, Dubinsky M, Silverberg M, Griffiths A, Grant SF, Satsangi J, Baldassano R, Hakonarson H
Am J Hum Genet. 2009
PubMed ID: 19249008
GnRH-regulated expression of Jun and JUN target genes in gonadotropes requires a functional interaction between TCF/LEF family members and beta-catenin.
Salisbury TB, Binder AK, Grammer JC, Nilson JH
Mol Endocrinol. 2009
PubMed ID: 19131506
Genetic delineation of the pathways mediated by bid and JNK in tumor necrosis factor-alpha-induced liver injury in adult and embryonic mice.
Ni HM, Chen X, Shi YH, Liao Y, Beg AA, Fan J, Yin XM
J Biol Chem. 2009
PubMed ID: 19060338
The coactivator CRTC1 promotes cell proliferation and transformation via AP-1.
Canettieri G, Coni S, Della Guardia M, Nocerino V, Antonucci L, Di Magno L, Screaton R, Screpanti I, Giannini G, Gulino A
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19164581
Adiponectin improves cardiomyocyte contractile function in db/db diabetic obese mice.
Dong F, Ren J
Obesity (Silver Spring). 2009
PubMed ID: 19057532
The nuclear receptors NUR77 and SF1 play additive roles with c-JUN through distinct elements on the mouse Star promoter.
Martin LJ, Tremblay JJ
J Mol Endocrinol. 2009
PubMed ID: 18987158
Differential induction of c-Fos and c-Jun in the lateral geniculate nucleus of rats following unilateral optic nerve injury with contralateral retinal blockade.
Dai Y, Sun X, Chen Q
Exp Brain Res. 2009
PubMed ID: 18854993
The phagosomal proteome in interferon-gamma-activated macrophages.
Trost M, English L, Lemieux S, Courcelles M, Desjardins M, Thibault P
Immunity. 2009
PubMed ID: 19144319
Transcriptional synergy mediated by SAF-1 and AP-1: critical role of N-terminal polyalanine and two zinc finger domains of SAF-1.
Kumar D, Ray A, Ray BK
J Biol Chem. 2009
PubMed ID: 19028685
Rexinoid-induced expression of IGFBP-6 requires RARbeta-dependent permissive cooperation of retinoid receptors and AP-1.
Uray IP, Shen Q, Seo HS, Kim H, Lamph WW, Bissonnette RP, Brown PH
J Biol Chem. 2009
PubMed ID: 18957410
Genetical genomic determinants of alcohol consumption in rats and humans.
Tabakoff B, Saba L, Printz M, Flodman P, Hodgkinson C, Goldman D, Koob G, Richardson HN, Kechris K, Bell RL, Hübner N, Heinig M, Pravenec M, Mangion J, Legault L, Dongier M, Conigrave KM, Whitfield JB, Saunders J, Grant B, Hoffman PL, WHO/ISBRA Study on State and Trait Markers of Alcoholism
BMC Biol. 2009
PubMed ID: 19874574
LMP1-augmented kappa intron enhancer activity contributes to upregulation expression of Ig kappa light chain via NF-kappaB and AP-1 pathways in nasopharyngeal carcinoma cells.
Liu H, Zheng H, Duan Z, Hu D, Li M, Liu S, Li Z, Deng X, Wang Z, Tang M, Shi Y, Yi W, Cao Y
Mol Cancer. 2009
PubMed ID: 19860880
Basal cancer cell survival involves JNK2 suppression of a novel JNK1/c-Jun/Bcl-3 apoptotic network.
Ahmed SU, Milner J
PLoS One. 2009
PubMed ID: 19806201
Transcription factor AP-1 in esophageal squamous cell carcinoma: alterations in activity and expression during human Papillomavirus infection.
Hussain S, Bharti AC, Salam I, Bhat MA, Mir MM, Hedau S, Siddiqi MA, Basir SF, Das BC
BMC Cancer. 2009
PubMed ID: 19758438
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
PubMed ID: 19690332
[The comparative analysis of psoriasis and Crohn disease molecular-genetical processes under pathological conditions]
Piruzian ES, Ishkin AA, Nikol'skaia TA, Abdeev RM, Bruskin SA
Mol Biol (Mosk). 2009
PubMed ID: 19334540
Aldosterone-induced TGF-beta1 expression is regulated by mitogen-activated protein kinases and activator protein-1 in mesangial cells.
Han JS, Choi BS, Yang CW, Kim YS
J Korean Med Sci. 2009
PubMed ID: 19194552
Inhibition of AP-1 transcriptional activity blocks the migration, invasion, and experimental metastasis of murine osteosarcoma.
Leaner VD, Chick JF, Donninger H, Linniola I, Mendoza A, Khanna C, Birrer MJ
Am J Pathol. 2009
PubMed ID: 19074613
In vivo study on the effects of microcystin extracts on the expression profiles of proto-oncogenes (c-fos, c-jun and c-myc) in liver, kidney and testis of male Wistar rats injected i.v. with toxins.
Li H, Xie P, Li G, Hao L, Xiong Q
Toxicon. 2009
PubMed ID: 19041662
Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study.
Vega A, Salas A, Milne RL, Carracedo B, Ribas G, Ruibal A, de León AC, González-Hernández A, Benítez J, Carracedo A
Gynecol Oncol. 2009
PubMed ID: 18950845
NDRG2 suppresses cell proliferation through down-regulation of AP-1 activity in human colon carcinoma cells.
Kim YJ, Yoon SY, Kim JT, Choi SC, Lim JS, Kim JH, Song EY, Lee HG, Choi I, Kim JW
Int J Cancer. 2009
PubMed ID: 18844221
Differential binding of the transcription factors Sp1, AP-1, and NFI to the promoter of the human alpha5 integrin gene dictates its transcriptional activity.
Gingras ME, Masson-Gadais B, Zaniolo K, Leclerc S, Drouin R, Germain L, Guérin SL
Invest Ophthalmol Vis Sci. 2009
PubMed ID: 18775869
Long-range enhancer differentially regulated by c-Jun and JunD controls peptidylarginine deiminase-3 gene in keratinocytes.
Adoue V, Chavanas S, Coudane F, Méchin MC, Caubet C, Ying S, Dong S, Duplan H, Charveron M, Takahara H, Serre G, Simon M
J Mol Biol. 2008
PubMed ID: 18952102
Parkin regulates Eg5 expression by Hsp70 ubiquitination-dependent inactivation of c-Jun NH2-terminal kinase.
Liu M, Aneja R, Sun X, Xie S, Wang H, Wu X, Dong JT, Li M, Joshi HC, Zhou J
J Biol Chem. 2008
PubMed ID: 18845538
Simultaneous blockade of AP-1 and phosphatidylinositol 3-kinase pathway in non-small cell lung cancer cells.
Kikuchi J, Kinoshita I, Shimizu Y, Oizumi S, Nishimura M, Birrer MJ, Dosaka-Akita H
Br J Cancer. 2008
PubMed ID: 19018257
Evidence that the bZIP domains of the Jun transcription factor bind to DNA as monomers prior to folding and homodimerization.
Seldeen KL, McDonald CB, Deegan BJ, Farooq A
Arch Biochem Biophys. 2008
PubMed ID: 18940179
Differences in c-jun and nNOS expression levels in motoneurons following different kinds of axonal injury in adult rats.
Zhou LH, Han S, Xie YY, Wang LL, Yao ZB
Brain Cell Biol. 2008
PubMed ID: 19238548
[Growth factors may enhance c-fos and c-jun gene expressions of hepatic stellate cells]
Wang AM, Ren CH, Xiang Y
Zhonghua Gan Zang Bing Za Zhi. 2008
PubMed ID: 19105933
EGF stimulates uPAR expression and cell invasiveness through ERK, AP-1, and NF-kappaB signaling in human gastric carcinoma cells.
Baek MK, Kim MH, Jang HJ, Park JS, Chung IJ, Shin BA, Ahn BW, Jung YD
Oncol Rep. 2008
PubMed ID: 19020743
1-Methyl-4-phenyl-pyridinium ion-induced oxidative stress, c-Jun phosphorylation and DNA fragmentation factor-45 cleavage in SK-N-SH cells are averted by selegiline.
Chetsawang B, Kooncumchoo P, Govitrapong P, Ebadi M
Neurochem Int. 2008
PubMed ID: 18805449
Inhibition of transcriptional activity of c-JUN by SIRT1.
Gao Z, Ye J
Biochem Biophys Res Commun. 2008
PubMed ID: 18823944
Fast regulation of AP-1 activity through interaction of lamin A/C, ERK1/2, and c-Fos at the nuclear envelope.
González JM, Navarro-Puche A, Casar B, Crespo P, Andrés V
J Cell Biol. 2008
PubMed ID: 19015316
Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion.
Fromigué O, Hamidouche Z, Marie PJ
J Biol Chem. 2008
PubMed ID: 18757369
Rosmarinic acid antagonizes activator protein-1-dependent activation of cyclooxygenase-2 expression in human cancer and nonmalignant cell lines.
Scheckel KA, Degner SC, Romagnolo DF
J Nutr. 2008
PubMed ID: 18936204
Epstein-Barr virus-encoded EBNA1 modulates the AP-1 transcription factor pathway in nasopharyngeal carcinoma cells and enhances angiogenesis in vitro.
O'Neil JD, Owen TJ, Wood VH, Date KL, Valentine R, Chukwuma MB, Arrand JR, Dawson CW, Young LS
J Gen Virol. 2008
PubMed ID: 18931081
The role of JUN in the regulation of PRKCC-mediated STAR expression and steroidogenesis in mouse Leydig cells.
Manna PR, Stocco DM
J Mol Endocrinol. 2008
PubMed ID: 18755854
Lysosomal localization of ubiquitinated Jun requires multiple determinants in a lysine-27-linked polyubiquitin conjugate.
Ikeda H, Kerppola TK
Mol Biol Cell. 2008
PubMed ID: 18716056
Activator protein-1 and smad proteins synergistically regulate human follicle-stimulating hormone beta-promoter activity.
Wang Y, Fortin J, Lamba P, Bonomi M, Persani L, Roberson MS, Bernard DJ
Endocrinology. 2008
PubMed ID: 18653705
Characterization of the transduction pathway involved in c-fos and c-jun expression induced by Aggregatibacter actinomycetemcomitans lipopolysaccharides in human gingival fibroblasts.
Gutiérrez-Venegas G, Castillo-Alemán R
Int Immunopharmacol. 2008
PubMed ID: 18621151
Heregulin-beta promotes matrix metalloproteinase-7 expression via HER2-mediated AP-1 activation in MCF-7 cells.
Yuan G, Qian L, Song L, Shi M, Li D, Yu M, Hu M, Shen B, Guo N
Mol Cell Biochem. 2008
PubMed ID: 18600430
IL-6/sIL-6R enhances cathepsin B and L production via caveolin-1-mediated JNK-AP-1 pathway in human gingival fibroblasts.
Yamaguchi T, Naruishi K, Arai H, Nishimura F, Takashiba S
J Cell Physiol. 2008
PubMed ID: 18543249
Thermodynamic analysis of the heterodimerization of leucine zippers of Jun and Fos transcription factors.
Seldeen KL, McDonald CB, Deegan BJ, Farooq A
Biochem Biophys Res Commun. 2008
PubMed ID: 18725194
The role of the transcription factor AP-1 in colitis-associated and beta-catenin-dependent intestinal tumorigenesis in mice.
Hasselblatt P, Gresh L, Kudo H, Guinea-Viniegra J, Wagner EF
Oncogene. 2008
PubMed ID: 18679426
Superoxide dismutase attenuates hyperoxia-induced interleukin-8 induction via AP-1.
Joseph A, Li Y, Koo HC, Davis JM, Pollack S, Kazzaz JA
Free Radic Biol Med. 2008
PubMed ID: 18692129
Genome-wide studies highlight indirect links between human replication origins and gene regulation.
Cadoret JC, Meisch F, Hassan-Zadeh V, Luyten I, Guillet C, Duret L, Quesneville H, Prioleau MN
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18838675
Interactions between SIRT1 and AP-1 reveal a mechanistic insight into the growth promoting properties of alumina (Al2O3) nanoparticles in mouse skin epithelial cells.
Dey S, Bakthavatchalu V, Tseng MT, Wu P, Florence RL, Grulke EA, Yokel RA, Dhar SK, Yang HS, Chen Y, St Clair DK
Carcinogenesis. 2008
PubMed ID: 18676681
Functional characterization of the human immunodeficiency virus type 1 Nef acidic domain.
Baugh LL, Garcia JV, Foster JL
J Virol. 2008
PubMed ID: 18653452
Transcriptional co-factor CDCA4 participates in the regulation of JUN oncogene expression.
Tategu M, Nakagawa H, Hayashi R, Yoshida K
Biochimie. 2008
PubMed ID: 18572021
A genomic and expression study of AP-1 in primary cutaneous T-cell lymphoma: evidence for dysregulated expression of JUNB and JUND in MF and SS.
Mao X, Orchard G, Mitchell TJ, Oyama N, Russell-Jones R, Vermeer MH, Willemze R, van Doorn R, Tensen CP, Young BD, Whittaker SJ
J Cutan Pathol. 2008
PubMed ID: 18494816
c-Jun, Fra-2, and ATF-2 immunoreactivity in the jejunal tissues of the healthy rat.
Keklikoglu N
Dig Dis Sci. 2008
PubMed ID: 18320311
Piperonyl butoxide activates c-Jun and ATF-2 in the hepatocytes of mice.
Muguruma M, Arai K, Moto M, Nishimura J, Dewa Y, Mitsumori K
Arch Toxicol. 2008
PubMed ID: 18228000
Activation of Polo-like kinase 3 by hypoxic stresses.
Wang L, Gao J, Dai W, Lu L
J Biol Chem. 2008
PubMed ID: 18650425
TAK1 regulates reactive oxygen species and cell death in keratinocytes, which is essential for skin integrity.
Omori E, Morioka S, Matsumoto K, Ninomiya-Tsuji J
J Biol Chem. 2008
PubMed ID: 18606807
Interleukin (IL) 1beta induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase-dependent AKT/IkappaB kinase alpha pathway targeting activator protein-1.
Cahill CM, Rogers JT
J Biol Chem. 2008
PubMed ID: 18515365
Phosphorylation of Thr-178 and Thr-184 in the TAK1 T-loop is required for interleukin (IL)-1-mediated optimal NFkappaB and AP-1 activation as well as IL-6 gene expression.
Yu Y, Ge N, Xie M, Sun W, Burlingame S, Pass AK, Nuchtern JG, Zhang D, Fu S, Schneider MD, Fan J, Yang J
J Biol Chem. 2008
PubMed ID: 18617512
[Activator protein-1 mRNA expression, cell proliferation and collagen synthesis induced by tumor necrosis factor-alpha in cardiac fibroblasts from rats and the effect of Qiangxin Decoction]
Shen Y, Yan SY
Zhong Xi Yi Jie He Xue Bao. 2008
PubMed ID: 18782540
Grhl3 and Lmo4 play coordinate roles in epidermal migration.
Hislop NR, Caddy J, Ting SB, Auden A, Vasudevan S, King SL, Lindeman GJ, Visvader JE, Cunningham JM, Jane SM
Dev Biol. 2008
PubMed ID: 18619436
Novel insight in the association between salmonellosis or campylobacteriosis and chronic illness, and the role of host genetics in susceptibility to these diseases.
Doorduyn Y, Van Pelt W, Siezen CL, Van Der Horst F, Van Duynhoven YT, Hoebee B, Janssen R
Epidemiol Infect. 2008
PubMed ID: 18062835
Stretch-induced activation of the transcription factor activator protein-1 controls monocyte chemoattractant protein-1 expression during arteriogenesis.
Demicheva E, Hecker M, Korff T
Circ Res. 2008
PubMed ID: 18669921
Constitutive hypophosphorylation of extracellular signal-regulated kinases-1/2 and down-regulation of c-Jun in human gastric adenocarcinoma.
Wu WK, Sung JJ, Yu L, Li ZJ, Chu KM, Cho CH
Biochem Biophys Res Commun. 2008
PubMed ID: 18570890
Inhibition of myoblast differentiation by tumor necrosis factor alpha is mediated by c-Jun N-terminal kinase 1 and leukemia inhibitory factor.
Alter J, Rozentzweig D, Bengal E
J Biol Chem. 2008
PubMed ID: 18552402
IRF2-binding protein-1 is a JDP2 ubiquitin ligase and an inhibitor of ATF2-dependent transcription.
Kimura M
FEBS Lett. 2008
PubMed ID: 18671972
A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
c-Jun Is critical for the progression of osteosarcoma: proof in an orthotopic spontaneously metastasizing model.
Dass CR, Khachigian LM, Choong PF
Mol Cancer Res. 2008
PubMed ID: 18708361
L-selectin ligation-induced CSF-1 gene transcription is regulated by AP-1 in a c-Abl kinase-dependent manner.
Chen C, Shang X, Cui L, Xu T, Luo J, Ba X, Zeng X
Hum Immunol. 2008
PubMed ID: 18619508
Molecular mechanisms controlling GLUT4 intracellular retention.
Blot V, McGraw TE
Mol Biol Cell. 2008
PubMed ID: 18550797
Restriction to Fos family members of Trip6-dependent coactivation and glucocorticoid receptor-dependent trans-repression of activator protein-1.
Diefenbacher M, Sekula S, Heilbock C, Maier JV, Litfin M, van Dam H, Castellazzi M, Herrlich P, Kassel O
Mol Endocrinol. 2008
PubMed ID: 18535250
Eps15 mediates vesicle trafficking from the trans-Golgi network via an interaction with the clathrin adaptor AP-1.
Chi S, Cao H, Chen J, McNiven MA
Mol Biol Cell. 2008
PubMed ID: 18524853
Involvement of c-jun in human liposarcoma growth: supporting data from clinical immunohistochemistry and DNAzyme efficacy.
Dass CR, Galloway SJ, Clark JC, Khachigian LM, Choong PF
Cancer Biol Ther. 2008
PubMed ID: 18497564
The G protein-coupled receptor GPR30 inhibits human urothelial cell proliferation.
Teng J, Wang ZY, Prossnitz ER, Bjorling DE
Endocrinology. 2008
PubMed ID: 18467434
AP-1 activity rises by stimulation-dependent c-Fos expression in auditory neurons.
Rosskothen N, Hirschmüller-Ohmes I, Illing RB
Neuroreport. 2008
PubMed ID: 18596606
[The role of activator protein-1 in unstable coronary atherosclerotic changes]
Miao GH, Yang LX, Qi F, Wang XM, Shi YK, Li MQ
Zhonghua Nei Ke Za Zhi. 2008
PubMed ID: 19035162
Transforming growth factor-beta-mediated tumor necrosis factor-related apoptosis-inducing ligand expression and apoptosis in hepatoma cells requires functional cooperation between Smad proteins and activator protein-1.
Herzer K, Grosse-Wilde A, Krammer PH, Galle PR, Kanzler S
Mol Cancer Res. 2008
PubMed ID: 18644981
Thrombin activates Ras-CREB/ATF-1 signaling and stimulates c-fos, c-jun, and c-myc expression in human gingival fibroblasts.
Chan CP, Chang MC, Wang YJ, Chen LI, Tsai YL, Lee JJ, Jia HW, Jeng JH
J Periodontol. 2008
PubMed ID: 18597608
Antiinflammatory activity of methanol extract isolated from stem bark of Magnolia kobus.
Kang JS, Lee KH, Han MH, Lee H, Ahn JM, Han SB, Han G, Lee K, Park SK, Kim HM
Phytother Res. 2008
PubMed ID: 18521967
Both IKKalpha and IKKbeta are implicated in the arsenite-induced AP-1 transactivation correlating with cell apoptosis through NF-kappaB activity-independent manner.
Song L, Li J, Hu M, Huang C
Exp Cell Res. 2008
PubMed ID: 18508047
The activation of NF-kappaB and AP-1 in peripheral blood mononuclear cells isolated from patients with diabetic nephropathy.
Nam JS, Cho MH, Lee GT, Park JS, Ahn CW, Cha BS, Lim SK, Kim KR, Ha HJ, Lee HC
Diabetes Res Clin Pract. 2008
PubMed ID: 18485515
Extracellular signals regulate rapid coactivator recruitment at AP-1 sites by altered phosphorylation of both CREB binding protein and c-jun.
Tsai LN, Ku TK, Salib NK, Crowe DL
Mol Cell Biol. 2008
PubMed ID: 18443043
c-Jun controls histone modifications, NF-kappaB recruitment, and RNA polymerase II function to activate the ccl2 gene.
Wolter S, Doerrie A, Weber A, Schneider H, Hoffmann E, von der Ohe J, Bakiri L, Wagner EF, Resch K, Kracht M
Mol Cell Biol. 2008
PubMed ID: 18443042
Downregulation of c-jun results in apoptosis-mediated anti-osteosarcoma activity in an orthotopic model.
Dass CR, Friedhuber AM, Khachigian LM, Dunstan DE, Choong PF
Cancer Biol Ther. 2008
PubMed ID: 18414033
AP-1 and AP-3 mediate sorting of melanosomal and lysosomal membrane proteins into distinct post-Golgi trafficking pathways.
Chapuy B, Tikkanen R, Mühlhausen C, Wenzel D, von Figura K, Höning S
Traffic. 2008
PubMed ID: 18410487
ERK signaling regulates tumor promoter induced c-Jun recruitment at the Fra-1 promoter.
Adiseshaiah P, Li J, Vaz M, Kalvakolanu DV, Reddy SP
Biochem Biophys Res Commun. 2008
PubMed ID: 18435914
Time-course of immediate early gene expression in hippocampal subregions of adrenalectomized rats after acute corticosterone challenge.
Hansson AC, Fuxe K
Brain Res. 2008
PubMed ID: 18485334
Disruption of Krox20-Nab interaction in the mouse leads to peripheral neuropathy with biphasic evolution.
Desmazières A, Decker L, Vallat JM, Charnay P, Gilardi-Hebenstreit P
J Neurosci. 2008
PubMed ID: 18524893
Targeting the activator protein 1 transcription factor for the prevention of estrogen receptor-negative mammary tumors.
Shen Q, Uray IP, Li Y, Zhang Y, Hill J, Xu XC, Young MR, Gunther EJ, Hilsenbeck SG, Colburn NH, Chodosh LA, Brown PH
Cancer Prev Res (Phila). 2008
PubMed ID: 19138935
Decoy oligodeoxynucleotide targeting activator protein-1 (AP-1) attenuates intestinal inflammation in murine experimental colitis.
Moriyama I, Ishihara S, Rumi MA, Aziz MD, Mishima Y, Oshima N, Kadota C, Kadowaki Y, Amano Y, Kinoshita Y
Lab Invest. 2008
PubMed ID: 18458670
A human homolog of mouse Lbh gene, hLBH, expresses in heart and activates SRE and AP-1 mediated MAPK signaling pathway.
Ai J, Wang Y, Tan K, Deng Y, Luo N, Yuan W, Wang Z, Li Y, Wang Y, Mo X, Zhu C, Yin Z, Liu M, Wu X
Mol Biol Rep. 2008
PubMed ID: 17390236
Benzo(a)pyrene-caused increased G1-S transition requires the activation of c-Jun through p53-dependent PI-3K/Akt/ERK pathway in human embryo lung fibroblasts.
Jiao S, Liu B, Gao A, Ye M, Jia X, Zhang F, Liu H, Shi X, Huang C
Toxicol Lett. 2008
PubMed ID: 18448277
c-Jun is a negative regulator of myelination.
Parkinson DB, Bhaskaran A, Arthur-Farraj P, Noon LA, Woodhoo A, Lloyd AC, Feltri ML, Wrabetz L, Behrens A, Mirsky R, Jessen KR
J Cell Biol. 2008
PubMed ID: 18490512
miR-21 Gene expression triggered by AP-1 is sustained through a double-negative feedback mechanism.
Fujita S, Ito T, Mizutani T, Minoguchi S, Yamamichi N, Sakurai K, Iba H
J Mol Biol. 2008
PubMed ID: 18384814
Transcriptional regulation of EGR-1 by the interleukin-1-JNK-MKK7-c-Jun pathway.
Hoffmann E, Ashouri J, Wolter S, Doerrie A, Dittrich-Breiholz O, Schneider H, Wagner EF, Troppmair J, Mackman N, Kracht M
J Biol Chem. 2008
PubMed ID: 18281687
[Role of c-jun in the effect of genistein on neonatal rat calvaria osteoblasts proliferation and differentiation]
Zhang Y, Jin H, Xu Z, Nan W
Wei Sheng Yan Jiu. 2008
PubMed ID: 18646529
[Overexpression and higher phosphorylation of p53 induced by benzo(a) pyrene through activated protein 1 independent pathway]
Ye M, Liu B, Jia X, Gao A
Wei Sheng Yan Jiu. 2008
PubMed ID: 18646516
[Molecular cloning and preliminary function study of a novel human gene AC3-33 related to suppress AP-1 activity]
Liu P, Deng WW, Gao P, Lu Y, Sun B, Li M, Zhao J, Shi TP, Zhang XJ
Yi Chuan. 2008
PubMed ID: 18487146
Doubly truncated FosB isoform (Delta2DeltaFosB) induces osteosclerosis in transgenic mice and modulates expression and phosphorylation of Smads in osteoblasts independent of intrinsic AP-1 activity.
Sabatakos G, Rowe GC, Kveiborg M, Wu M, Neff L, Chiusaroli R, Philbrick WM, Baron R
J Bone Miner Res. 2008
PubMed ID: 18433296
Coupling of folding and DNA-binding in the bZIP domains of Jun-Fos heterodimeric transcription factor.
Seldeen KL, McDonald CB, Deegan BJ, Farooq A
Arch Biochem Biophys. 2008
PubMed ID: 18316037
Secretogranin II: a key AP-1-regulated protein that mediates neuronal differentiation and protection from nitric oxide-induced apoptosis of neuroblastoma cells.
Li L, Hung AC, Porter AG
Cell Death Differ. 2008
PubMed ID: 18239671
A model for neuronal competition during development.
Deppmann CD, Mihalas S, Sharma N, Lonze BE, Niebur E, Ginty DD
Science. 2008
PubMed ID: 18323418
COP1D, an alternatively spliced constitutive photomorphogenic-1 (COP1) product, stabilizes UV stress-induced c-Jun through inhibition of full-length COP1.
Savio MG, Rotondo G, Maglie S, Rossetti G, Bender JR, Pardi R
Oncogene. 2008
PubMed ID: 17968316
Calcineurin-mediated dephosphorylation of c-Jun Ser-243 is required for c-Jun protein stability and cell transformation.
Huang CC, Wang JM, Kikkawa U, Mukai H, Shen MR, Morita I, Chen BK, Chang WC
Oncogene. 2008
PubMed ID: 17952113
Chlamydia pneumoniae infection and hyperlipidaemia-induced expression of P50 and c-Fos in the heart of C57BL6J mice.
Huang B, Dong Y, Cheng Y, Xie Q, Lin G, Wu Y, Feng Y, Li J, Mai W
Acta Cardiol. 2008
PubMed ID: 18468197
Differential roles for Nrf2 and AP-1 in upregulation of HO-1 expression by arsenite in murine embryonic fibroblasts.
Harada H, Sugimoto R, Watanabe A, Taketani S, Okada K, Warabi E, Siow R, Itoh K, Yamamoto M, Ishii T
Free Radic Res. 2008
PubMed ID: 18404528
Expression of transcription factors NF-kappaB and AP-1 in nasal polyposis.
Valera FC, Queiroz R, Scrideli C, Tone LG, Anselmo-Lima WT
Clin Exp Allergy. 2008
PubMed ID: 18352974
Inhibition of GSK3 differentially modulates NF-kappaB, CREB, AP-1 and beta-catenin signaling in hepatocytes, but fails to promote TNF-alpha-induced apoptosis.
Götschel F, Kern C, Lang S, Sparna T, Markmann C, Schwager J, McNelly S, von Weizsäcker F, Laufer S, Hecht A, Merfort I
Exp Cell Res. 2008
PubMed ID: 18261723
FoxP3 maintains Treg unresponsiveness by selectively inhibiting the promoter DNA-binding activity of AP-1.
Lee SM, Gao B, Fang D
Blood. 2008
PubMed ID: 18223166
Disruption of c-Jun reduces cellular migration and invasion through inhibition of c-Src and hyperactivation of ROCK II kinase.
Jiao X, Katiyar S, Liu M, Mueller SC, Lisanti MP, Li A, Pestell TG, Wu K, Ju X, Li Z, Wagner EF, Takeya T, Wang C, Pestell RG
Mol Biol Cell. 2008
PubMed ID: 18216279
Nuclear Dvl, c-Jun, beta-catenin, and TCF form a complex leading to stabilization of beta-catenin-TCF interaction.
Gan XQ, Wang JY, Xi Y, Wu ZL, Li YP, Li L
J Cell Biol. 2008
PubMed ID: 18347071
Structural polymorphism exhibited by a homopurine.homopyrimidine sequence found at the right end of human c-jun protooncogene.
Saxena S, Bansal A, Kukreti S
Arch Biochem Biophys. 2008
PubMed ID: 18262488
Neuronal injury-inducible gene is synergistically regulated by ATF3, c-Jun, and STAT3 through the interaction with Sp1 in damaged neurons.
Kiryu-Seo S, Kato R, Ogawa T, Nakagomi S, Nagata K, Kiyama H
J Biol Chem. 2008
PubMed ID: 18192274
c-Jun supports ribosomal RNA processing and nucleolar localization of RNA helicase DDX21.
Holmström TH, Mialon A, Kallio M, Nymalm Y, Mannermaa L, Holm T, Johansson H, Black E, Gillespie D, Salminen TA, Langel U, Valdez BC, Westermarck J
J Biol Chem. 2008
PubMed ID: 18180292
Estrogen induces estrogen-related receptor alpha gene expression and chromatin structural changes in estrogen receptor (ER)-positive and ER-negative breast cancer cells.
Hu P, Kinyamu HK, Wang L, Martin J, Archer TK, Teng C
J Biol Chem. 2008
PubMed ID: 18174157
Activation of the cAMP pathway synergistically increases IL-1-induced IL-6 gene expression in FRTL-5 thyroid cells: involvement of AP-1 transcription factors.
Szabo-Fresnais N, Blondeau JP, Pomérance M
Mol Cell Endocrinol. 2008
PubMed ID: 18280640
Activator protein-1 involved in growth inhibition by RASSF1A gene in the human gastric carcinoma cell line SGC7901.
Deng ZH, Wen JF, Li JH, Xiao DS, Zhou JH
World J Gastroenterol. 2008
PubMed ID: 18322962
DNA damage-dependent translocation of B23 and p19 ARF is regulated by the Jun N-terminal kinase pathway.
Yogev O, Saadon K, Anzi S, Inoue K, Shaulian E
Cancer Res. 2008
PubMed ID: 18316603
MAP kinase pathways in UV-induced apoptosis of retinal pigment epithelium ARPE19 cells.
Roduit R, Schorderet DF
Apoptosis. 2008
PubMed ID: 18253836
Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane.
Símová S, Klíma M, Cermak L, Sourková V, Andera L
Apoptosis. 2008
PubMed ID: 18165900
Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos.
Nishioka N, Yamamoto S, Kiyonari H, Sato H, Sawada A, Ota M, Nakao K, Sasaki H
Mech Dev. 2008
PubMed ID: 18083014
Glucocorticoid receptor is required for skin barrier competence.
Bayo P, Sanchis A, Bravo A, Cascallana JL, Buder K, Tuckermann J, Schütz G, Pérez P
Endocrinology. 2008
PubMed ID: 18039792
NRF-1, and AP-1 regulate the promoter of the human calpain small subunit 1 (CAPNS1) gene.
Asangani IA, Rasheed SA, Leupold JH, Post S, Allgayer H
Gene. 2008
PubMed ID: 18234454
Basic fibroblast growth factor-induced neuronal differentiation of mouse bone marrow stromal cells requires FGFR-1, MAPK/ERK, and transcription factor AP-1.
Yang H, Xia Y, Lu SQ, Soong TW, Feng ZW
J Biol Chem. 2008
PubMed ID: 18171671
The tyrosine binding pocket in the adaptor protein 1 (AP-1) mu1 subunit is necessary for Nef to recruit AP-1 to the major histocompatibility complex class I cytoplasmic tail.
Wonderlich ER, Williams M, Collins KL
J Biol Chem. 2008
PubMed ID: 18073204
Endoplasmic reticulum stress increases the expression of methylenetetrahydrofolate reductase through the IRE1 transducer.
Leclerc D, Rozen R
J Biol Chem. 2008
PubMed ID: 18065414
c-Myc inhibits Ras-mediated differentiation of pheochromocytoma cells by blocking c-Jun up-regulation.
Vaqué JP, Fernández-García B, García-Sanz P, Ferrandiz N, Bretones G, Calvo F, Crespo P, Marín MC, León J
Mol Cancer Res. 2008
PubMed ID: 18314492
[Effects of CpG-ODN combined with HBsAg on the phenotype, function and the activity of NF-kappa B and AP-1 of monocyte-derived dendritic cells in chronic hepatitis B patients]
Xiang XX, Zhou XQ, Xie Q, Yu H, Zhou HJ
Zhonghua Gan Zang Bing Za Zhi. 2008
PubMed ID: 18304423
Homocysteine induces monocyte chemoattractant protein-1 expression in hepatocytes mediated via activator protein-1 activation.
Woo CW, Siow YL, O K
J Biol Chem. 2008
PubMed ID: 18024959
The AP-1 transcription factor regulates breast cancer cell growth via cyclins and E2F factors.
Shen Q, Uray IP, Li Y, Krisko TI, Strecker TE, Kim HT, Brown PH
Oncogene. 2008
PubMed ID: 17637753
Visualization of AP-1 NF-kappaB ternary complexes in living cells by using a BiFC-based FRET.
Shyu YJ, Suarez CD, Hu CD
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18172215
Required roles of Bax and JNKs in central and peripheral nervous system death of retinoblastoma-deficient mice.
Keramaris E, Ruzhynsky VA, Callaghan SM, Wong E, Davis RJ, Flavell R, Slack RS, Park DS
J Biol Chem. 2008
PubMed ID: 17984095
Clinicopathological significance of expression of p-c-Jun, TCF4 and beta-Catenin in colorectal tumors.
Takeda K, Kinoshita I, Shimizu Y, Ohba Y, Itoh T, Matsuno Y, Shichinohe T, Dosaka-Akita H
BMC Cancer. 2008
PubMed ID: 18992165
Long-range enhancer associated with chromatin looping allows AP-1 regulation of the peptidylarginine deiminase 3 gene in differentiated keratinocyte.
Chavanas S, Adoue V, Méchin MC, Ying S, Dong S, Duplan H, Charveron M, Takahara H, Serre G, Simon M
PLoS One. 2008
PubMed ID: 18923650
Divergent mechanisms underlie Smad4-mediated positive regulation of the three genes encoding the basement membrane component laminin-332 (laminin-5).
Zboralski D, Böckmann M, Zapatka M, Hoppe S, Schöneck A, Hahn SA, Schmiegel W, Schwarte-Waldhoff I
BMC Cancer. 2008
PubMed ID: 18664273
High glucose enhances lipopolysaccharide-stimulated CD14 expression in U937 mononuclear cells by increasing nuclear factor kappaB and AP-1 activities.
Nareika A, Im YB, Game BA, Slate EH, Sanders JJ, London SD, Lopes-Virella MF, Huang Y
J Endocrinol. 2008
PubMed ID: 18180316
o-GlcNAc transferase is activated by CaMKIV-dependent phosphorylation under potassium chloride-induced depolarization in NG-108-15 cells.
Song M, Kim HS, Park JM, Kim SH, Kim IH, Ryu SH, Suh PG
Cell Signal. 2008
PubMed ID: 18029144
Upregulation of AP1 by tertiary butyl hydroperoxide induced oxidative stress and subsequent effect on spermatogenesis in mice testis.
Kaur P, Kaur G, Bansal MP
Mol Cell Biochem. 2008
PubMed ID: 17934699
Negative charged threonine 95 of c-Jun is essential for c-Jun N-terminal kinase-dependent phosphorylation of threonine 91/93 and stress-induced c-Jun biological activity.
Vinciguerra M, Esposito I, Salzano S, Madeo A, Nagel G, Maggiolini M, Gallo A, Musti AM
Int J Biochem Cell Biol. 2008
PubMed ID: 17920329
Antagonistic control of cell fates by JNK and p38-MAPK signaling.
Wada T, Stepniak E, Hui L, Leibbrandt A, Katada T, Nishina H, Wagner EF, Penninger JM
Cell Death Differ. 2008
PubMed ID: 17762881
SKAP55 modulates T cell antigen receptor-induced activation of the Ras-Erk-AP1 pathway by binding RasGRP1.
Kosco KA, Cerignoli F, Williams S, Abraham RT, Mustelin T
Mol Immunol. 2008
PubMed ID: 17658605
ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex.
Li Z, Tognon CE, Godinho FJ, Yasaitis L, Hock H, Herschkowitz JI, Lannon CL, Cho E, Kim SJ, Bronson RT, Perou CM, Sorensen PH, Orkin SH
Cancer Cell. 2007
PubMed ID: 18068631
Role of transcriptional factors Sp1, c-Rel, and c-Jun in LPS-induced C/EBPdelta gene expression of mouse macrophages.
Liu YW, Chen CC, Wang JM, Chang WC, Huang YC, Chung SY, Chen BK, Hung JJ
Cell Mol Life Sci. 2007
PubMed ID: 17965828
Bacterial induction of early response genes and activation of proapoptotic factors in pleural mesothelial cells.
Mohammed KA, Nasreen N, Antony VB
Lung. 2007
PubMed ID: 17929089
Effects of transcription factor activator protein-1 on interleukin-8 expression and enteritis in response to Clostridium difficile toxin A.
Lee JY, Park HR, Oh YK, Kim YJ, Youn J, Han JS, Kim JM
J Mol Med. 2007
PubMed ID: 17639289
Tissue-specific deletion of c-Jun in the pancreas has limited effects on pancreas formation.
Yamamoto K, Miyatsuka T, Tanaka A, Toyoda S, Kato K, Shiraiwa T, Fujitani Y, Yamasaki Y, Hori M, Matsuhisa M, Matsuoka TA, Kaneto H
Biochem Biophys Res Commun. 2007
PubMed ID: 17920562
Stress-induced c-Jun activation mediated by Polo-like kinase 3 in corneal epithelial cells.
Wang L, Dai W, Lu L
J Biol Chem. 2007
PubMed ID: 17804415
c-Jun, a crucial molecule in metastasis of breast cancer and potential target for biotherapy.
Zhang Y, Pu X, Shi M, Chen L, Qian L, Song Y, Yuan G, Zhang H, Yu M, Hu M, Shen B, Guo N
Oncol Rep. 2007
PubMed ID: 17914574
Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death.
Wang X, Nadarajah B, Robinson AC, McColl BW, Jin JW, Dajas-Bailador F, Boot-Handford RP, Tournier C
Mol Cell Biol. 2007
PubMed ID: 17875933
Human placenta promotes IL-8 expression through activation of JNK/SAPK and transcription factors NF-kappaB and AP-1 in PMA-differentiated THP-1 cells.
Kang SS, Woo SS, Im J, Yang JS, Yun CH, Ju HR, Son CG, Moon EY, Han SH
Int Immunopharmacol. 2007
PubMed ID: 17761353
Inverse expression of Jun activation domain binding protein 1 and cell cycle inhibitor p27Kip1: influence on proliferation in hepatocellular carcinoma.
Berg JP, Zhou Q, Breuhahn K, Schirmacher P, Patil MA, Chen X, Schäfer N, Höller TT, Fischer HP, Büttner R, Gütgemann I
Hum Pathol. 2007
PubMed ID: 17651785
Heat Shock Protein 90 regulates the stability of c-Jun in HEK293 Cells.
Lu C, Chen D, Zhang Z, Fang F, Wu Y, Luo L, Yin Z
Mol Cells. 2007
PubMed ID: 17978573
Hepatocyte survival in acute hepatitis is due to c-Jun/AP-1-dependent expression of inducible nitric oxide synthase.
Hasselblatt P, Rath M, Komnenovic V, Zatloukal K, Wagner EF
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17940019
Heterodimerization with Jun family members regulates c-Fos nucleocytoplasmic traffic.
Malnou CE, Salem T, Brockly F, Wodrich H, Piechaczyk M, Jariel-Encontre I
J Biol Chem. 2007
PubMed ID: 17681951
dp5/HRK is a c-Jun target gene and required for apoptosis induced by potassium deprivation in cerebellar granule neurons.
Ma C, Ying C, Yuan Z, Song B, Li D, Liu Y, Lai B, Li W, Chen R, Ching YP, Li M
J Biol Chem. 2007
PubMed ID: 17428807
Deferoxamine synergistically enhances iron-mediated AP-1 activation: a showcase of the interplay between extracellular-signal-regulated kinase and tyrosine phosphatase.
Huang X, Dai J, Huang C, Zhang Q, Bhanot O, Pelle E
Free Radic Res. 2007
PubMed ID: 17886035
Eosinophilic inflammation: mechanisms regulating IL-5 transcription in human T lymphocytes.
Wang J, Young IG
Allergy. 2007
PubMed ID: 17845581
Overt expression of AP-1 reduces alpha myosin heavy chain expression and contributes to heart failure from chronic volume overload.
Freire G, Ocampo C, Ilbawi N, Griffin AJ, Gupta M
J Mol Cell Cardiol. 2007
PubMed ID: 17720185
Stromally expressed c-Jun regulates proliferation of prostate epithelial cells.
Li W, Wu CL, Febbo PG, Olumi AF
Am J Pathol. 2007
PubMed ID: 17702894
Interleukin-10 inhibits RANKL-mediated expression of NFATc1 in part via suppression of c-Fos and c-Jun in RAW264.7 cells and mouse bone marrow cells.
Mohamed SG, Sugiyama E, Shinoda K, Taki H, Hounoki H, Abdel-Aziz HO, Maruyama M, Kobayashi M, Ogawa H, Miyahara T
Bone. 2007
PubMed ID: 17627913
Sequential actions of ERK1/2 on the AP-1 transcription factor allow temporal integration of metabolic signals in pancreatic beta cells.
Glauser DA, Schlegel W
FASEB J. 2007
PubMed ID: 17504975
Biphasic regulation of AP-1 subunits during human epidermal wound healing.
Neub A, Houdek P, Ohnemus U, Moll I, Brandner JM
J Invest Dermatol. 2007
PubMed ID: 17495958
Nuclear import of c-Jun is mediated by multiple transport receptors.
Waldmann I, Wälde S, Kehlenbach RH
J Biol Chem. 2007
PubMed ID: 17652081
Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.
Janssen R, Bont L, Siezen CL, Hodemaekers HM, Ermers MJ, Doornbos G, van 't Slot R, Wijmenga C, Goeman JJ, Kimpen JL, van Houwelingen HC, Kimman TG, Hoebee B
J Infect Dis. 2007
PubMed ID: 17703412
Induction of activator protein-1 and nuclear factor-kappaB as a prerequisite for disease development in susceptible SJL/J mice after theiler murine encephalomyelitis.
Gerhauser I, Ulrich R, Alldinger S, Baumgärtner W
J Neuropathol Exp Neurol. 2007
PubMed ID: 17805011
Induction of choline kinase alpha by carbon tetrachloride (CCl4) occurs via increased binding of c-jun to an AP-1 element.
Aoyama C, Ishidate K, Sugimoto H, Vance DE
Biochim Biophys Acta. 2007
PubMed ID: 17728180
Genetic control directed toward spontaneous IFN-alpha/IFN-beta responses and downstream IFN-gamma expression influences the pathogenesis of a murine psoriasis-like skin disease.
Arakura F, Hida S, Ichikawa E, Yajima C, Nakajima S, Saida T, Taki S
J Immunol. 2007
PubMed ID: 17709541
Amino acid residues required for physical and cooperative transcriptional interaction of STAT3 and AP-1 proteins c-Jun and c-Fos.
Ginsberg M, Czeko E, Müller P, Ren Z, Chen X, Darnell JE
Mol Cell Biol. 2007
PubMed ID: 17636030
Distribution of cells expressing Jun and Fos proteins and synthesizing DNA in the adrenal cortex of hypophysectomized rats: regulation by ACTH and FGF2.
Torres TE, Lotfi CF
Cell Tissue Res. 2007
PubMed ID: 17551755
Dimer composition and promoter context contribute to functional cooperation between AP-1 and NFAT.
Wisniewska MB, Ameyar-Zazoua M, Bakiri L, Kaminska B, Yaniv M, Weitzman JB
J Mol Biol. 2007
PubMed ID: 17588603
Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells.
Breitwieser W, Lyons S, Flenniken AM, Ashton G, Bruder G, Willington M, Lacaud G, Kouskoff V, Jones N
Genes Dev. 2007
PubMed ID: 17699753
[Effect of phosphorylated c-Jun expression on COX-2 expression in the substantia nigra of MPTP mouse model of subacute Parkinson disease]
Wang YS, Zhou JP, Wei ZF, Tian QY, Zhou HX, Zhang YX
Nan Fang Yi Ke Da Xue Xue Bao. 2007
PubMed ID: 17715026
Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas.
Strom A, Bonal C, Ashery-Padan R, Hashimoto N, Campos ML, Trumpp A, Noda T, Kido Y, Real FX, Thorel F, Herrera PL
Development. 2007
PubMed ID: 17596282
Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stress.
Lin Q, Weis S, Yang G, Weng YH, Helston R, Rish K, Smith A, Bordner J, Polte T, Gaunitz F, Dennery PA
J Biol Chem. 2007
PubMed ID: 17430897
Tumor necrosis factor alpha (TNFalpha) stimulates Map4k4 expression through TNFalpha receptor 1 signaling to c-Jun and activating transcription factor 2.
Tesz GJ, Guilherme A, Guntur KV, Hubbard AC, Tang X, Chawla A, Czech MP
J Biol Chem. 2007
PubMed ID: 17500068
The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch.
Oberst A, Malatesta M, Aqeilan RI, Rossi M, Salomoni P, Murillas R, Sharma P, Kuehn MR, Oren M, Croce CM, Bernassola F, Melino G
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17592138
c-Jun has multiple enhancing activities in the novel cross talk between the androgen receptor and Ets variant gene 1 in prostate cancer.
Cai C, Hsieh CL, Shemshedini L
Mol Cancer Res. 2007
PubMed ID: 17634427
Molecular basis for autoregulatory interaction between GAE domain and hinge region of GGA1.
Inoue M, Shiba T, Ihara K, Yamada Y, Hirano S, Kamikubo H, Kataoka M, Kawasaki M, Kato R, Nakayama K, Wakatsuki S
Traffic. 2007
PubMed ID: 17506864
Role of IKK and ERK pathways in intrinsic inflammation of cystic fibrosis airways.
Verhaeghe C, Remouchamps C, Hennuy B, Vanderplasschen A, Chariot A, Tabruyn SP, Oury C, Bours V
Biochem Pharmacol. 2007
PubMed ID: 17466952
Infarct volume after transient middle cerebral artery occlusion (MCAo) can be reduced by attenuation but not by inactivation of c-Jun action.
Vogel J, Weigand MA, Behrens A, Wagner EF, Schorpp-Kistner M, Zimmermann M, Schenkel J
Brain Res. 2007
PubMed ID: 17428453
The effects of different auditory activity on the expression of phosphorylated c-Jun in the auditory system.
Ruan Q, Wang D, Gao H, Liu A, Da C, Yin S, Chi F
Acta Otolaryngol. 2007
PubMed ID: 17503228
p38alpha suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway.
Hui L, Bakiri L, Mairhorfer A, Schweifer N, Haslinger C, Kenner L, Komnenovic V, Scheuch H, Beug H, Wagner EF
Nat Genet. 2007
PubMed ID: 17468757
Mouse models of psoriasis.
Gudjonsson JE, Johnston A, Dyson M, Valdimarsson H, Elder JT
J Invest Dermatol. 2007
PubMed ID: 17429444
1,25(OH)(2)D(3) blocks TNF-induced monocytic tissue factor expression by inhibition of transcription factors AP-1 and NF-kappaB.
Chung J, Koyama T, Ohsawa M, Shibamiya A, Hoshi A, Hirosawa S
Lab Invest. 2007
PubMed ID: 17401435
PTEN down regulates AP-1 and targets c-fos in human glioma cells via PI3-kinase/Akt pathway.
Koul D, Shen R, Shishodia S, Takada Y, Bhat KP, Reddy SA, Aggarwal BB, Yung WK
Mol Cell Biochem. 2007
PubMed ID: 17235455
Glycated albumin induces activation of activator protein-1 in retinal glial cells.
Okumura A, Mitamura Y, Namekata K, Nakamura K, Harada C, Harada T
Jpn J Ophthalmol. 2007
PubMed ID: 17554491
Src induces urokinase receptor gene expression and invasion/intravasation via activator protein-1/p-c-Jun in colorectal cancer.
Leupold JH, Asangani I, Maurer GD, Lengyel E, Post S, Allgayer H
Mol Cancer Res. 2007
PubMed ID: 17510314
Regulation of alphabeta/gammadelta T cell development by the activator protein 1 transcription factor c-Jun.
Riera-Sans L, Behrens A
J Immunol. 2007
PubMed ID: 17442952
Caspase-8- and JNK-dependent AP-1 activation is required for Fas ligand-induced IL-8 production.
Matsumoto N, Imamura R, Suda T
FEBS J. 2007
PubMed ID: 17403042
Estrogen receptor alpha and the activating protein-1 complex cooperate during insulin-like growth factor-I-induced transcriptional activation of the pS2/TFF1 gene.
Baron S, Escande A, Albérola G, Bystricky K, Balaguer P, Richard-Foy H
J Biol Chem. 2007
PubMed ID: 17317669
c-Jun homodimers can function as a context-specific coactivator.
Grondin B, Lefrancois M, Tremblay M, Saint-Denis M, Haman A, Waga K, Bédard A, Tenen DG, Hoang T
Mol Cell Biol. 2007
PubMed ID: 17283046
Methylation-controlled J protein promotes c-Jun degradation to prevent ABCB1 transporter expression.
Hatle KM, Neveu W, Dienz O, Rymarchyk S, Barrantes R, Hale S, Farley N, Lounsbury KM, Bond JP, Taatjes D, Rincón M
Mol Cell Biol. 2007
PubMed ID: 17283040
Immunohistochemical Jun/Fos protein localization and DNA synthesis in rat adrenal cortex after treatment with ACTH or FGF2.
Baccaro RB, Mendonça PO, Torres TE, Lotfi CF
Cell Tissue Res. 2007
PubMed ID: 17216194
Proteomic identification of C/EBP-DBD multiprotein complex: JNK1 activates stem cell regulator C/EBPalpha by inhibiting its ubiquitination.
Trivedi AK, Bararia D, Christopeit M, Peerzada AA, Singh SM, Kieser A, Hiddemann W, Behre HM, Behre G
Oncogene. 2007
PubMed ID: 16983342
TGFbeta1 regulation of vimentin gene expression during differentiation of the C2C12 skeletal myogenic cell line requires Smads, AP-1 and Sp1 family members.
Wu Y, Zhang X, Salmon M, Lin X, Zehner ZE
Biochim Biophys Acta. 2007
PubMed ID: 17270292
PP2B-mediated dephosphorylation of c-Jun C terminus regulates phorbol ester-induced c-Jun/Sp1 interaction in A431 cells.
Chen BK, Huang CC, Chang WC, Chen YJ, Kikkawa U, Nakahama K, Morita I, Chang WC
Mol Biol Cell. 2007
PubMed ID: 17215518
Preventing polyglutamine-induced activation of c-Jun delays neuronal dysfunction in a mouse model of SCA7 retinopathy.
Merienne K, Friedman J, Akimoto M, Abou-Sleymane G, Weber C, Swaroop A, Trottier Y
Neurobiol Dis. 2007
PubMed ID: 17189700
Cell fate determination factor DACH1 inhibits c-Jun-induced contact-independent growth.
Wu K, Liu M, Li A, Donninger H, Rao M, Jiao X, Lisanti MP, Cvekl A, Birrer M, Pestell RG
Mol Biol Cell. 2007
PubMed ID: 17182846
DDB1 is essential for genomic stability in developing epidermis.
Cang Y, Zhang J, Nicholas SA, Kim AL, Zhou P, Goff SP
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17301228
The activator protein-1 transcription factor in respiratory epithelium carcinogenesis.
Karamouzis MV, Konstantinopoulos PA, Papavassiliou AG
Mol Cancer Res. 2007
PubMed ID: 17314269
Differential mechanisms of transcriptional regulation of the mouse osteocalcin gene by Jun family members.
Akhouayri O, St-Arnaud R
Calcif Tissue Int. 2007
PubMed ID: 17308994
Haplotype-independent costimulation of IL-10 secretion by SDF-1/CXCL12 proceeds via AP-1 binding to the human IL-10 promoter.
Kremer KN, Kumar A, Hedin KE
J Immunol. 2007
PubMed ID: 17237407
The B cell antigen receptor controls AP-1 and NFAT activity through Ras-mediated activation of Ral.
de Gorter DJ, Vos JC, Pals ST, Spaargaren M
J Immunol. 2007
PubMed ID: 17237388
Somatic excision demonstrates that c-Jun induces cellular migration and invasion through induction of stem cell factor.
Katiyar S, Jiao X, Wagner E, Lisanti MP, Pestell RG
Mol Cell Biol. 2007
PubMed ID: 17145782
Mitogen activated protein kinase-dependent activation of c-Jun and c-Fos is required for neuronal differentiation but not for growth and stress response in PC12 cells.
Eriksson M, Taskinen M, Leppä S
J Cell Physiol. 2007
PubMed ID: 17111371
Activation of MKK4 (SEK1), JNK, and c-Jun in labial salivary infiltrating T cells in patients with Sjögren's syndrome.
Soejima K, Nakamura H, Tamai M, Kawakami A, Eguchi K
Rheumatol Int. 2007
PubMed ID: 17009014
c-Jun promotes cellular survival by suppression of PTEN.
Hettinger K, Vikhanskaya F, Poh MK, Lee MK, de Belle I, Zhang JT, Reddy SA, Sabapathy K
Cell Death Differ. 2007
PubMed ID: 16676006
Tacrolimus and cyclosporine A inhibit human osteoclast formation via targeting the calcineurin-dependent NFAT pathway and an activation pathway for c-Jun or MITF in rheumatoid arthritis.
Miyazaki M, Fujikawa Y, Takita C, Tsumura H
Clin Rheumatol. 2007
PubMed ID: 16586042
c-Jun downregulation by HDAC3-dependent transcriptional repression promotes osmotic stress-induced cell apoptosis.
Xia Y, Wang J, Liu TJ, Yung WK, Hunter T, Lu Z
Mol Cell. 2007
PubMed ID: 17244530
The role of activating protein 1 in the transcriptional regulation of the human FCGR2B promoter mediated by the -343 G -> C polymorphism associated with systemic lupus erythematosus.
Olferiev M, Masuda E, Tanaka S, Blank MC, Pricop L
J Biol Chem. 2007
PubMed ID: 17130130
Stress-induced c-Jun-dependent Vitamin D receptor (VDR) activation dissects the non-classical VDR pathway from the classical VDR activity.
Li QP, Qi X, Pramanik R, Pohl NM, Loesch M, Chen G
J Biol Chem. 2007
PubMed ID: 17121851
The LIM protein, Limd1, regulates AP-1 activation through an interaction with Traf6 to influence osteoclast development.
Feng Y, Zhao H, Luderer HF, Epple H, Faccio R, Ross FP, Teitelbaum SL, Longmore GD
J Biol Chem. 2007
PubMed ID: 17092936
Hyperactive variants of p38alpha induce, whereas hyperactive variants of p38gamma suppress, activating protein 1-mediated transcription.
Askari N, Diskin R, Avitzour M, Capone R, Livnah O, Engelberg D
J Biol Chem. 2007
PubMed ID: 17088247
Deregulation of AP-1 proteins in collagen gel-induced epithelial cell apoptosis mediated by low substratum rigidity.
Wang YH, Chiu WT, Wang YK, Wu CC, Chen TL, Teng CF, Chang WT, Chang HC, Tang MJ
J Biol Chem. 2007
PubMed ID: 17085440
EGF-R is expressed and AP-1 and NF-kappaB are activated in stromal myofibroblasts surrounding colon adenocarcinomas paralleling expression of COX-2 and VEGF.
Konstantinopoulos PA, Vandoros GP, Karamouzis MV, Gkermpesi M, Sotiropoulou-Bonikou G, Papavassiliou AG
Cell Oncol. 2007
PubMed ID: 18032824
Critical role of c-Jun overexpression in liver metastasis of human breast cancer xenograft model.
Zhang Y, Pu X, Shi M, Chen L, Song Y, Qian L, Yuan G, Zhang H, Yu M, Hu M, Shen B, Guo N
BMC Cancer. 2007
PubMed ID: 17672916
MEKK1 mediates the ubiquitination and degradation of c-Jun in response to osmotic stress.
Xia Y, Wang J, Xu S, Johnson GL, Hunter T, Lu Z
Mol Cell Biol. 2007
PubMed ID: 17101801
TBP is differentially regulated by c-Jun N-terminal kinase 1 (JNK1) and JNK2 through Elk-1, controlling c-Jun expression and cell proliferation.
Zhong S, Fromm J, Johnson DL
Mol Cell Biol. 2007
PubMed ID: 17074809
Inhibition of AMP-activated protein kinase suppresses IL-2 expression through down-regulation of NF-AT and AP-1 activation in Jurkat T cells.
Jhun BS, Lee JY, Oh YT, Lee JH, Choe W, Baik HH, Kim SS, Yoon KS, Ha J, Kang I
Biochem Biophys Res Commun. 2006
PubMed ID: 17097050
The HECT ubiquitin ligase AIP4 regulates the cell surface expression of select TRP channels.
Wegierski T, Hill K, Schaefer M, Walz G
EMBO J. 2006
PubMed ID: 17110928
c-Jun and JunB are essential for hypoglycemia-mediated VEGF induction.
Textor B, Sator-Schmitt M, Richter KH, Angel P, Schorpp-Kistner M
Ann N Y Acad Sci. 2006
PubMed ID: 17341624
Cyclooxygenase-2 gene transcription in a macrophage model of inflammation.
Kang YJ, Wingerd BA, Arakawa T, Smith WL
J Immunol. 2006
PubMed ID: 17114486
Squamous cell carcinoma growth in mice and in culture is regulated by c-Jun and its control of matrix metalloproteinase-2 and -9 expression.
Zhang G, Luo X, Sumithran E, Pua VS, Barnetson RS, Halliday GM, Khachigian LM
Oncogene. 2006
PubMed ID: 16785994
Elafin prevents lipopolysaccharide-induced AP-1 and NF-kappaB activation via an effect on the ubiquitin-proteasome pathway.
Butler MW, Robertson I, Greene CM, O'Neill SJ, Taggart CC, McElvaney NG
J Biol Chem. 2006
PubMed ID: 16980310
The c-Jun N-terminal kinase activator dual leucine zipper kinase regulates axon growth and neuronal migration in the developing cerebral cortex.
Hirai S, Cui de F, Miyata T, Ogawa M, Kiyonari H, Suda Y, Aizawa S, Banba Y, Ohno S
J Neurosci. 2006
PubMed ID: 17108173
Role of selenium in spermatogenesis: differential expression of cjun and cfos in tubular cells of mice testis.
Shalini S, Bansal MP
Mol Cell Biochem. 2006
PubMed ID: 17066317
Essential role of Jun family transcription factors in PU.1 knockdown-induced leukemic stem cells.
Steidl U, Rosenbauer F, Verhaak RG, Gu X, Ebralidze A, Otu HH, Klippel S, Steidl C, Bruns I, Costa DB, Wagner K, Aivado M, Kobbe G, Valk PJ, Passegué E, Libermann TA, Delwel R, Tenen DG
Nat Genet. 2006
PubMed ID: 17041602
Interactions between c-Jun, nuclear factor 1, and JC virus promoter sequences: implications for viral tropism.
Ravichandran V, Sabath BF, Jensen PN, Houff SA, Major EO
J Virol. 2006
PubMed ID: 16928756
Genetic linkage analysis of pulmonary fibrotic response to silica in mice.
Ohtsuka Y, Wang XT, Saito J, Ishida T, Munakata M
Eur Respir J. 2006
PubMed ID: 16837500
Crn7 interacts with AP-1 and is required for the maintenance of Golgi morphology and protein export from the Golgi.
Rybakin V, Gounko NV, Späte K, Höning S, Majoul IV, Duden R, Noegel AA
J Biol Chem. 2006
PubMed ID: 16905771
The tyrosine kinase c-Abl protects c-Jun from ubiquitination-mediated degradation in T cells.
Gao B, Lee SM, Fang D
J Biol Chem. 2006
PubMed ID: 16901904
An in vivo analysis of Schwann cell programmed cell death in embryonic mice: the role of axons, glial growth factor, and the pro-apoptotic gene Bax.
Winseck AK, Oppenheim RW
Eur J Neurosci. 2006
PubMed ID: 17042795
Identification and characterization of the CD226 gene promoter.
Jian JL, Zhu CS, Xu ZW, Ouyang WM, Ma DC, Zhang Y, Chen LJ, Yang AG, Jin BQ
J Biol Chem. 2006
PubMed ID: 16887814
JNK2 is a positive regulator of the cJun transcription factor.
Jaeschke A, Karasarides M, Ventura JJ, Ehrhardt A, Zhang C, Flavell RA, Shokat KM, Davis RJ
Mol Cell. 2006
PubMed ID: 16973441
Hypoxia protects HepG2 cells against etoposide-induced apoptosis via a HIF-1-independent pathway.
Piret JP, Cosse JP, Ninane N, Raes M, Michiels C
Exp Cell Res. 2006
PubMed ID: 16844113
Potential role of Jun activation domain-binding protein 1 as a negative regulator of p27kip1 in pancreatic adenocarcinoma.
Kouvaraki MA, Korapati AL, Rassidakis GZ, Tian L, Zhang Q, Chiao P, Ho L, Evans DB, Claret FX
Cancer Res. 2006
PubMed ID: 16951171
Tumor necrosis factor-alpha down-regulates human Cu/Zn superoxide dismutase 1 promoter via JNK/AP-1 signaling pathway.
Afonso V, Santos G, Collin P, Khatib AM, Mitrovic DR, Lomri N, Leitman DC, Lomri A
Free Radic Biol Med. 2006
PubMed ID: 16895791
A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers.
Li T, Santockyte R, Shen RF, Tekle E, Wang G, Yang DC, Chock PB
Arch Biochem Biophys. 2006
PubMed ID: 16620772
c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity.
Stepniak E, Ricci R, Eferl R, Sumara G, Sumara I, Rath M, Hui L, Wagner EF
Genes Dev. 2006
PubMed ID: 16912279
Nuclear retention of the tumor suppressor cPML by the homeodomain protein TGIF restricts TGF-beta signaling.
Seo SR, Ferrand N, Faresse N, Prunier C, Abécassis L, Pessah M, Bourgeade MF, Atfi A
Mol Cell. 2006
PubMed ID: 16916642
Role of transcription factor activator protein 1 (AP1) in epidermal growth factor-mediated protection against apoptosis induced by a DNA-damaging agent.
Takeuchi K, Motoda Y, Ito F
FEBS J. 2006
PubMed ID: 16911523
JUN siRNA regulates matrix metalloproteinase-2 expression, microvascular endothelial growth and retinal neovascularisation.
Zhang G, Fahmy RG, diGirolamo N, Khachigian LM
J Cell Sci. 2006
PubMed ID: 16847049
Cytohesin binder and regulator augments T cell receptor-induced nuclear factor of activated T Cells.AP-1 activation through regulation of the JNK pathway.
Chen Q, Coffey A, Bourgoin SG, Gadina M
J Biol Chem. 2006
PubMed ID: 16702224
PEA3 cooperates with c-Jun in regulation of HER2/neu transcription.
Matsui K, Sugimori K, Motomura H, Ejiri N, Tsukada K, Kitajima I
Oncol Rep. 2006
PubMed ID: 16786139
Human immunodeficiency virus type 1 Tat increases cooperation between AP-1 and NFAT transcription factors in T cells.
Hidalgo-Estévez AM, González E, Punzón C, Fresno M
J Gen Virol. 2006
PubMed ID: 16690925
SMAP2, a novel ARF GTPase-activating protein, interacts with clathrin and clathrin assembly protein and functions on the AP-1-positive early endosome/trans-Golgi network.
Natsume W, Tanabe K, Kon S, Yoshida N, Watanabe T, Torii T, Satake M
Mol Biol Cell. 2006
PubMed ID: 16571680
Redox-dependent matrix metalloproteinase-1 expression is regulated by JNK through Ets and AP-1 promoter motifs.
Nelson KK, Subbaram S, Connor KM, Dasgupta J, Ha XF, Meng TC, Tonks NK, Melendez JA
J Biol Chem. 2006
PubMed ID: 16569638
The DNA sequence and biological annotation of human chromosome 1.
Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K, Spencer CC, Jones MC, Gillson C, Searle S, Zhou Y, Kokocinski F, McDonald L, Evans R, Phillips K, Atkinson A, Cooper R, Jones C, Hall RE, Andrews TD, Lloyd C, Ainscough R, Almeida JP, Ambrose KD, Anderson F, Andrew RW, Ashwell RI, Aubin K, Babbage AK, Bagguley CL, Bailey J, Beasley H, Bethel G, Bird CP, Bray-Allen S, Brown JY, Brown AJ, Buckley D, Burton J, Bye J, Carder C, Chapman JC, Clark SY, Clarke G, Clee C, Cobley V, Collier RE, Corby N, Coville GJ, Davies J, Deadman R, Dunn M, Earthrowl M, Ellington AG, Errington H, Frankish A, Frankland J, French L, Garner P, Garnett J, Gay L, Ghori MR, Gibson R, Gilby LM, Gillett W, Glithero RJ, Grafham DV, Griffiths C, Griffiths-Jones S, Grocock R, Hammond S, Harrison ES, Hart E, Haugen E, Heath PD, Holmes S, Holt K, Howden PJ, Hunt AR, Hunt SE, Hunter G, Isherwood J, James R, Johnson C, Johnson D, Joy A, Kay M, Kershaw JK, Kibukawa M, Kimberley AM, King A, Knights AJ, Lad H, Laird G, Lawlor S, Leongamornlert DA, Lloyd DM, Loveland J, Lovell J, Lush MJ, Lyne R, Martin S, Mashreghi-Mohammadi M, Matthews L, Matthews NS, McLaren S, Milne S, Mistry S, Moore MJ, Nickerson T, O'Dell CN, Oliver K, Palmeiri A, Palmer SA, Parker A, Patel D, Pearce AV, Peck AI, Pelan S, Phelps K, Phillimore BJ, Plumb R, Rajan J, Raymond C, Rouse G, Saenphimmachak C, Sehra HK, Sheridan E, Shownkeen R, Sims S, Skuce CD, Smith M, Steward C, Subramanian S, Sycamore N, Tracey A, Tromans A, Van Helmond Z, Wall M, Wallis JM, White S, Whitehead SL, Wilkinson JE, Willey DL, Williams H, Wilming L, Wray PW, Wu Z, Coulson A, Vaudin M, Sulston JE, Durbin R, Hubbard T, Wooster R, Dunham I, Carter NP, McVean G, Ross MT, Harrow J, Olson MV, Beck S, Rogers J, Bentley DR, Banerjee R, Bryant SP, Burford DC, Burrill WD, Clegg SM, Dhami P, Dovey O, Faulkner LM, Gribble SM, Langford CF, Pandian RD, Porter KM, Prigmore E
Nature. 2006
PubMed ID: 16710414
Interacting JNK-docking sites in MKK7 promote binding and activation of JNK mitogen-activated protein kinases.
Ho DT, Bardwell AJ, Grewal S, Iverson C, Bardwell L
J Biol Chem. 2006
PubMed ID: 16533805
Differentiation of trophoblast giant cells and their metabolic functions are dependent on peroxisome proliferator-activated receptor beta/delta.
Nadra K, Anghel SI, Joye E, Tan NS, Basu-Modak S, Trono D, Wahli W, Desvergne B
Mol Cell Biol. 2006
PubMed ID: 16581799
Peroxisome-proliferator-activated receptor alpha agonists inhibit cyclo-oxygenase 2 and vascular endothelial growth factor transcriptional activation in human colorectal carcinoma cells via inhibition of activator protein-1.
Grau R, Punzón C, Fresno M, Iñiguez MA
Biochem J. 2006
PubMed ID: 16343055
Jab1, a novel protease-activated receptor-2 (PAR-2)-interacting protein, is involved in PAR-2-induced activation of activator protein-1.
Luo W, Wang Y, Hanck T, Stricker R, Reiser G
J Biol Chem. 2006
PubMed ID: 16410250
Mutual regulation of c-Jun and ATF2 by transcriptional activation and subcellular localization.
Liu H, Deng X, Shyu YJ, Li JJ, Taparowsky EJ, Hu CD
EMBO J. 2006
PubMed ID: 16511568
CREB-AP1 protein complexes regulate transcription of the collagen XXIV gene (Col24a1) in osteoblasts.
Matsuo N, Tanaka S, Gordon MK, Koch M, Yoshioka H, Ramirez F
J Biol Chem. 2006
PubMed ID: 16373341
Activation of activator protein-1 in mouse brain regions exposed to simulated microgravity.
Sarkar S, Wise KC, Manna SK, Ramesh V, Yamauchi K, Thomas RL, Wilson BL, Kulkarni AD, Pellis NR, Ramesh GT
In Vitro Cell Dev Biol Anim. 2006
PubMed ID: 16759155
Sp1 deacetylation induced by phorbol ester recruits p300 to activate 12(S)-lipoxygenase gene transcription.
Hung JJ, Wang YT, Chang WC
Mol Cell Biol. 2006
PubMed ID: 16478997
Japanese encephalitis virus NS2B-NS3 protease binding to phage-displayed human brain proteins with the domain of trypsin inhibitor and basic region leucine zipper.
Lin CW, Lin KH, Lyu PC, Chen WJ
Virus Res. 2006
PubMed ID: 16289409
Cell-type-selective induction of c-jun by TAF4b directs ovarian-specific transcription networks.
Geles KG, Freiman RN, Liu WL, Zheng S, Voronina E, Tjian R
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16473943
The human transcription factor AP-1 is a mediator of bile acid-induced liver cell apoptosis.
Bernt C, Vennegeerts T, Beuers U, Rust C
Biochem Biophys Res Commun. 2006
PubMed ID: 16380075
A role for Ets1, synergizing with AP-1 and GATA-3 in the regulation of IL-5 transcription in mouse Th2 lymphocytes.
Wang J, Shannon MF, Young IG
Int Immunol. 2006
PubMed ID: 16373364
4-Hydroxynonenal induces rat gamma-glutamyl transpeptidase through mitogen-activated protein kinase-mediated electrophile response element/nuclear factor erythroid 2-related factor 2 signaling.
Zhang H, Liu H, Iles KE, Liu RM, Postlethwait EM, Laperche Y, Forman HJ
Am J Respir Cell Mol Biol. 2006
PubMed ID: 16195535
Astrocyte-specific expression of the alpha1-antichymotrypsin and glial fibrillary acidic protein genes requires activator protein-1.
Gopalan SM, Wilczynska KM, Konik BS, Bryan L, Kordula T
J Biol Chem. 2006
PubMed ID: 16303762
The tyrosine kinase Syk regulates TPL2 activation signals.
Eliopoulos AG, Das S, Tsichlis PN
J Biol Chem. 2006
PubMed ID: 16291755
Altered regulation of c-jun and its involvement in anchorage-independent growth of human lung cancers.
Maeno K, Masuda A, Yanagisawa K, Konishi H, Osada H, Saito T, Ueda R, Takahashi T
Oncogene. 2006
PubMed ID: 16158054
Enhanced expression of selenocysteine lyase in acute glomerulonephritis and its regulation by AP-1.
Jafari C, Panzer U, Steinmetz OM, Zahner G, Stahl RA, Harendza S
Cell Mol Biol Lett. 2006
PubMed ID: 16874457
The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors.
Wissmüller S, Kosian T, Wolf M, Finzsch M, Wegner M
Nucleic Acids Res. 2006
PubMed ID: 16582099
Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci.
Stylianou IM, Korstanje R, Li R, Sheehan S, Paigen B, Churchill GA
Mamm Genome. 2006
PubMed ID: 16416088
Activator protein-1 in epiretinal membranes of patients with proliferative diabetic retinopathy.
Mitamura Y, Okumura A, Harada C, Namekata K, Nakamura K, Tashimo A, Ohtsuka K, Harada T
Diabetologia. 2006
PubMed ID: 16341687
Hyperbaric oxygen induces VEGF expression through ERK, JNK and c-Jun/AP-1 activation in human umbilical vein endothelial cells.
Lee CC, Chen SC, Tsai SC, Wang BW, Liu YC, Lee HM, Shyu KG
J Biomed Sci. 2006
PubMed ID: 16328781
p300 modulates HIV-1 gp120-induced apoptosis in human proximal tubular cells: associated with alteration of TGF-beta and Smad signaling.
Kapasi AA, Fan S, Singhal PC
Nephron Exp Nephrol. 2006
PubMed ID: 16179804
Synthetic Vpr protein activates activator protein-1, c-Jun N-terminal kinase, and NF-kappaB and stimulates HIV-1 transcription in promonocytic cells and primary macrophages.
Varin A, Decrion AZ, Sabbah E, Quivy V, Sire J, Van Lint C, Roques BP, Aggarwal BB, Herbein G
J Biol Chem. 2005
PubMed ID: 16243842
The transcription factors AP-1 and Ets are regulators of C3a receptor expression.
Schaefer M, Konrad S, Thalmann J, Rheinheimer C, Johswich K, Sohns B, Klos A
J Biol Chem. 2005
PubMed ID: 16253992
Induction of human LTBP-3 promoter activity by TGF-beta1 is mediated by Smad3/4 and AP-1 binding elements.
Kantola AK, Keski-Oja J, Koli K
Gene. 2005
PubMed ID: 16223572
Combination analysis of activator protein-1 family members, Sp1 and an activator protein-2alpha-related factor binding to different regions of the urokinase receptor gene in resected colorectal cancers.
Schewe DM, Biller T, Maurer G, Asangani IA, Leupold JH, Lengyel ER, Post S, Allgayer H
Clin Cancer Res. 2005
PubMed ID: 16361535
Hydrogen peroxide stimulates proliferation and migration of human prostate cancer cells through activation of activator protein-1 and up-regulation of the heparin affin regulatory peptide gene.
Polytarchou C, Hatziapostolou M, Papadimitriou E
J Biol Chem. 2005
PubMed ID: 16199533
Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress.
Guo D, Han J, Adam BL, Colburn NH, Wang MH, Dong Z, Eizirik DL, She JX, Wang CY
Biochem Biophys Res Commun. 2005
PubMed ID: 16236267
Role of AP-1 in ethanol-induced N-methyl-D-aspartate receptor 2B subunit gene up-regulation in mouse cortical neurons.
Qiang M, Ticku MK
J Neurochem. 2005
PubMed ID: 16313514
Chrysoeriol potently inhibits the induction of nitric oxide synthase by blocking AP-1 activation.
Choi DY, Lee JY, Kim MR, Woo ER, Kim YG, Kang KW
J Biomed Sci. 2005
PubMed ID: 16228289
Recruitment of nuclear factor Y to the inverted CCAAT element (ICE) by c-Jun and E1A stimulates basal transcription of the bone sialoprotein gene in osteosarcoma cells.
Su M, Bansal AK, Mantovani R, Sodek J
J Biol Chem. 2005
PubMed ID: 16087680
Galectin-3 modulates MUC2 mucin expression in human colon cancer cells at the level of transcription via AP-1 activation.
Song S, Byrd JC, Mazurek N, Liu K, Koo JS, Bresalier RS
Gastroenterology. 2005
PubMed ID: 16285957
NFkappaB and AP-1 differentially contribute to the induction of Mn-SOD and eNOS during the development of oxidant tolerance.
Rui T, Kvietys PR
FASEB J. 2005
PubMed ID: 16157693
Regulation of the transcriptional activity of c-Fos by ERK. A novel role for the prolyl isomerase PIN1.
Monje P, Hernández-Losa J, Lyons RJ, Castellone MD, Gutkind JS
J Biol Chem. 2005
PubMed ID: 16123044
RGS4 and RGS5 are in vivo substrates of the N-end rule pathway.
Lee MJ, Tasaki T, Moroi K, An JY, Kimura S, Davydov IV, Kwon YT
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16217033
Inhibition of histone deacetylation by trichostatin A intensifies the transcriptions of neuronal c-fos and c-jun genes after kainate stimulation.
Sng JC, Taniura H, Yoneda Y
Neurosci Lett. 2005
PubMed ID: 16002216
Increased expression of interleukin-6 by vasoactive intestinal peptide is associated with regulation of CREB, AP-1 and C/EBP, but not NF-kappaB, in mouse calvarial osteoblasts.
Persson E, Voznesensky OS, Huang YF, Lerner UH
Bone. 2005
PubMed ID: 16085472
Sodium lactate increases LPS-stimulated MMP and cytokine expression in U937 histiocytes by enhancing AP-1 and NF-kappaB transcriptional activities.
Nareika A, He L, Game BA, Slate EH, Sanders JJ, London SD, Lopes-Virella MF, Huang Y
Am J Physiol Endocrinol Metab. 2005
PubMed ID: 15941782
Histone deacetylase inhibitors suppress the induction of c-Jun and its target genes including COX-2.
Yamaguchi K, Lantowski A, Dannenberg AJ, Subbaramaiah K
J Biol Chem. 2005
PubMed ID: 15994313
Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins.
Zenz R, Eferl R, Kenner L, Florin L, Hummerich L, Mehic D, Scheuch H, Angel P, Tschachler E, Wagner EF
Nature. 2005
PubMed ID: 16163348
Regulation of lipopolysaccharide-induced lung inflammation by plasminogen activator Inhibitor-1 through a JNK-mediated pathway.
Arndt PG, Young SK, Worthen GS
J Immunol. 2005
PubMed ID: 16148154
Treatment of experimental asthma by decoy-mediated local inhibition of activator protein-1.
Desmet C, Gosset P, Henry E, Garzé V, Faisca P, Vos N, Jaspar F, Mélotte D, Lambrecht B, Desmecht D, Pajak B, Moser M, Lekeux P, Bureau F
Am J Respir Crit Care Med. 2005
PubMed ID: 15961692
Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development.
Nateri AS, Spencer-Dene B, Behrens A
Nature. 2005
PubMed ID: 16007074
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Roxithromycin suppresses involucrin expression by modulation of activator protein-1 and nuclear factor-kappaB activities of keratinocytes.
Takahashi H, Hashimoto Y, Ishida-Yamamoto A, Iizuka H
J Dermatol Sci. 2005
PubMed ID: 16140218
Increased activity of activator protein-1 transcription factor components ATF2, c-Jun, and c-Fos in human and mouse autosomal dominant polycystic kidney disease.
Le NH, van der Wal A, van der Bent P, Lantinga-van Leeuwen IS, Breuning MH, van Dam H, de Heer E, Peters DJ
J Am Soc Nephrol. 2005
PubMed ID: 16049073
c-Jun controls the efficiency of MAP kinase signaling by transcriptional repression of MAP kinase phosphatases.
Sprowles A, Robinson D, Wu YM, Kung HJ, Wisdom R
Exp Cell Res. 2005
PubMed ID: 15950217
Heat shock treatment suppresses angiotensin II-induced SP-1 and AP-1 and stimulates Oct-1 DNA-binding activity in heart.
Chen Y, Currie RW
Inflamm Res. 2005
PubMed ID: 16158334
Polyinosinic acid induces TNF and NO production as well as NF-kappaB and AP-1 transcriptional activation in the monocytemacrophage cell line RAW 264.7.
Campa VM, Iglesias JM, Carcedo MT, Rodríguez R, Riera J, Ramos S, Lazo PS
Inflamm Res. 2005
PubMed ID: 16158333
Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation.
Bossis G, Malnou CE, Farras R, Andermarcher E, Hipskind R, Rodriguez M, Schmidt D, Muller S, Jariel-Encontre I, Piechaczyk M
Mol Cell Biol. 2005
PubMed ID: 16055710
The tumor suppressor p16(INK4a) prevents cell transformation through inhibition of c-Jun phosphorylation and AP-1 activity.
Choi BY, Choi HS, Ko K, Cho YY, Zhu F, Kang BS, Ermakova SP, Ma WY, Bode AM, Dong Z
Nat Struct Mol Biol. 2005
PubMed ID: 16007099
C-jun activation in acquired cystic kidney disease and renal cell carcinoma.
Oya M, Mikami S, Mizuno R, Marumo K, Mukai M, Murai M
J Urol. 2005
PubMed ID: 16006965
Human immunodeficiency virus type 1 envelope glycoprotein 120 induces cyclooxygenase-2 expression in neuroblastoma cells through a nuclear factor-kappaB and activating protein-1 mediated mechanism.
Alvarez S, Serramía MJ, Fresno M, Muñoz-Fernández M
J Neurochem. 2005
PubMed ID: 16001969
Direct association of hepatopoietin with thioredoxin constitutes a redox signal transduction in activation of AP-1/NF-kappaB.
Li Y, Liu W, Xing G, Tian C, Zhu Y, He F
Cell Signal. 2005
PubMed ID: 15894171
Inhibition of activator protein-1, NF-kappaB, and MAPKs and induction of phase 2 detoxifying enzyme activity by chlorogenic acid.
Feng R, Lu Y, Bowman LL, Qian Y, Castranova V, Ding M
J Biol Chem. 2005
PubMed ID: 15944151
Methylation adjacent to negatively regulating AP-1 site reactivates TrkA gene expression during cancer progression.
Fujimoto M, Kitazawa R, Maeda S, Kitazawa S
Oncogene. 2005
PubMed ID: 15870692
A novel human KRAB-containing zinc-finger gene ZNF446 inhibits transcriptional activities of SRE and AP-1.
Liu F, Zhu C, Xiao J, Wang Y, Tang W, Yuan W, Zhao Y, Li Y, Xiang Z, Wu X, Liu M
Biochem Biophys Res Commun. 2005
PubMed ID: 15936718
Differential involvement of calmodulin-dependent protein kinase II-activated AP-1 and c-Jun N-terminal kinase-activated EGR-1 signaling pathways in tumor necrosis factor-alpha and lipopolysaccharide-induced CD44 expression in human monocytic cells.
Mishra JP, Mishra S, Gee K, Kumar A
J Biol Chem. 2005
PubMed ID: 15923644
TCDD induces c-jun expression via a novel Ah (dioxin) receptor-mediated p38-MAPK-dependent pathway.
Weiss C, Faust D, Dürk H, Kolluri SK, Pelzer A, Schneider S, Dietrich C, Oesch F, Göttlicher M
Oncogene. 2005
PubMed ID: 15897893
Imaging Erg and Jun transcription factor interaction in living cells using fluorescence resonance energy transfer analyses.
Camuzeaux B, Spriet C, Héliot L, Coll J, Duterque-Coquillaud M
Biochem Biophys Res Commun. 2005
PubMed ID: 15922298
Activation of transcription factors NF-kappaB and AP-1 and their relations with apoptosis associated-proteins in hepatocellular carcinoma.
Guo LL, Xiao S, Guo Y
World J Gastroenterol. 2005
PubMed ID: 15991283
The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase.
Wei W, Jin J, Schlisio S, Harper JW, Kaelin WG
Cancer Cell. 2005
PubMed ID: 16023596
Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling.
Zeng Q, Li S, Chepeha DB, Giordano TJ, Li J, Zhang H, Polverini PJ, Nor J, Kitajewski J, Wang CY
Cancer Cell. 2005
PubMed ID: 16023595
IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis.
Maeda S, Kamata H, Luo JL, Leffert H, Karin M
Cell. 2005
PubMed ID: 15989949
Ascochlorin inhibits matrix metalloproteinase-9 expression by suppressing activator protein-1-mediated gene expression through the ERK1/2 signaling pathway: inhibitory effects of ascochlorin on the invasion of renal carcinoma cells.
Hong S, Park KK, Magae J, Ando K, Lee TS, Kwon TK, Kwak JY, Kim CH, Chang YC
J Biol Chem. 2005
PubMed ID: 15863510
Prolactin and estrogen enhance the activity of activating protein 1 in breast cancer cells: role of extracellularly regulated kinase 1/2-mediated signals to c-fos.
Gutzman JH, Nikolai SE, Rugowski DE, Watters JJ, Schuler LA
Mol Endocrinol. 2005
PubMed ID: 15746191
Mitogen regulated induction of FRA-1 proto-oncogene is controlled by the transcription factors binding to both serum and TPA response elements.
Adiseshaiah P, Peddakama S, Zhang Q, Kalvakolanu DV, Reddy SP
Oncogene. 2005
PubMed ID: 15806162
A role for c-fos/activator protein 1 in B lymphocyte terminal differentiation.
Ohkubo Y, Arima M, Arguni E, Okada S, Yamashita K, Asari S, Obata S, Sakamoto A, Hatano M, O-Wang J, Ebara M, Saisho H, Tokuhisa T
J Immunol. 2005
PubMed ID: 15944271
YB-1 represses AP1-dependent gene transactivation and interacts with an AP-1 DNA sequence.
Samuel S, Twizere JC, Bernstein LR
Biochem J. 2005
PubMed ID: 15702969
Neuroprotective effects of preconditioning ischemia on ischemic brain injury through down-regulating activation of JNK1/2 via N-methyl-D-aspartate receptor-mediated Akt1 activation.
Miao B, Yin XH, Pei DS, Zhang QG, Zhang GY
J Biol Chem. 2005
PubMed ID: 15797868
Phosphorylation of c-Jun in avian and mammalian motoneurons in vivo during programmed cell death: an early reversible event in the apoptotic cascade.
Sun W, Gould TW, Newbern J, Milligan C, Choi SY, Kim H, Oppenheim RW
J Neurosci. 2005
PubMed ID: 15944387
DNA topoisomerase I is a cofactor for c-Jun in the regulation of epidermal growth factor receptor expression and cancer cell proliferation.
Mialon A, Sankinen M, Söderström H, Junttila TT, Holmström T, Koivusalo R, Papageorgiou AC, Johnson RS, Hietanen S, Elenius K, Westermarck J
Mol Cell Biol. 2005
PubMed ID: 15923621
Retrograde axonal transport of JNK signaling molecules influence injury induced nuclear changes in p-c-Jun and ATF3 in adult rat sensory neurons.
Lindwall C, Kanje M
Mol Cell Neurosci. 2005
PubMed ID: 15911351
Differential inhibition of UVB-induced AP-1 and NF-kappaB transactivation by components of the jun bZIP domain.
Cooper S, Ranger-Moore J, Bowden TG
Mol Carcinog. 2005
PubMed ID: 15791649
Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light.
Tanos T, Marinissen MJ, Leskow FC, Hochbaum D, Martinetto H, Gutkind JS, Coso OA
J Biol Chem. 2005
PubMed ID: 15708845
Identification of c-Jun as a critical mediator for the intracrine 24 kDa FGF-2 isoform-induced cell proliferation.
Hortala M, Estival A, Pradayrol L, Susini C, Clemente F
Int J Cancer. 2005
PubMed ID: 15609298
Cell-free cotranslation and selection using in vitro virus for high-throughput analysis of protein-protein interactions and complexes.
Miyamoto-Sato E, Ishizaka M, Horisawa K, Tateyama S, Takashima H, Fuse S, Sue K, Hirai N, Masuoka K, Yanagawa H
Genome Res. 2005
PubMed ID: 15867431
Increased keratinocyte proliferation by JUN-dependent expression of PTN and SDF-1 in fibroblasts.
Florin L, Maas-Szabowski N, Werner S, Szabowski A, Angel P
J Cell Sci. 2005
PubMed ID: 15840658
Selective regulation of c-jun gene expression by mitogen-activated protein kinases via the 12-o-tetradecanoylphorbol-13-acetate- responsive element and myocyte enhancer factor 2 binding sites.
Kayahara M, Wang X, Tournier C
Mol Cell Biol. 2005
PubMed ID: 15831482
Activator protein-1 mediates shear stress-induced prostaglandin d synthase gene expression in vascular endothelial cells.
Miyagi M, Miwa Y, Takahashi-Yanaga F, Morimoto S, Sasaguri T
Arterioscler Thromb Vasc Biol. 2005
PubMed ID: 15718494
The promyelocytic leukemia protein PML regulates c-Jun function in response to DNA damage.
Salomoni P, Bernardi R, Bergmann S, Changou A, Tuttle S, Pandolfi PP
Blood. 2005
PubMed ID: 15626733
Cyclin A is a c-Jun target gene and is necessary for c-Jun-induced anchorage-independent growth in RAT1a cells.
Katabami M, Donninger H, Hommura F, Leaner VD, Kinoshita I, Chick JF, Birrer MJ
J Biol Chem. 2005
PubMed ID: 15737994
Differential regulation of c-Jun-dependent transcription by SUMO-specific proteases.
Cheng J, Perkins ND, Yeh ET
J Biol Chem. 2005
PubMed ID: 15701643
AFos dissociates cardiac myocyte hypertrophy and expression of the pathological gene program.
Jeong MY, Kinugawa K, Vinson C, Long CS
Circulation. 2005
PubMed ID: 15795322
Transforming growth factor-beta1 signaling participates in the physiological and pathological regulation of mouse inner ear development by all-trans retinoic acid.
Butts SC, Liu W, Li G, Frenz DA
Birth Defects Res A Clin Mol Teratol. 2005
PubMed ID: 15799023
AP-1 dimers regulate transcription of the p14/p19ARF tumor suppressor gene.
Ameyar-Zazoua M, Wisniewska MB, Bakiri L, Wagner EF, Yaniv M, Weitzman JB
Oncogene. 2005
PubMed ID: 15688012
Jun proteins modulate the ovary-specific promoter of aromatase gene in ovarian granulosa cells via a cAMP-responsive element.
Ghosh S, Wu Y, Li R, Hu Y
Oncogene. 2005
PubMed ID: 15688015
Ultraviolet irradiation induces Smad7 via induction of transcription factor AP-1 in human skin fibroblasts.
Quan T, He T, Voorhees JJ, Fisher GJ
J Biol Chem. 2005
PubMed ID: 15579469
Coactivation of nuclear receptors and myogenic factors induces the major BTG1 influence on muscle differentiation.
Busson M, Carazo A, Seyer P, Grandemange S, Casas F, Pessemesse L, Rouault JP, Wrutniak-Cabello C, Cabello G
Oncogene. 2005
PubMed ID: 15674337
Regulation of ultraviolet B radiation-mediated activation of AP1 signaling by retinoids in primary keratinocytes.
Darwiche N, Bazzi H, El-Touni L, Abou-Lteif G, Doueiri R, Hatoum A, Maalouf S, Gali-Muhtasib H
Radiat Res. 2005
PubMed ID: 15733037
JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage.
Yoshida K, Yamaguchi T, Natsume T, Kufe D, Miki Y
Nat Cell Biol. 2005
PubMed ID: 15696159
Identification of endogenous glucocorticoid repressed genes differentially regulated by a glucocorticoid receptor mutant able to separate between nuclear factor-kappaB and activator protein-1 repression.
Bladh LG, Lidén J, Dahlman-Wright K, Reimers M, Nilsson S, Okret S
Mol Pharmacol. 2005
PubMed ID: 15550679
Activity deprivation-dependent induction of the proapoptotic BH3-only protein Bim is independent of JNK/c-Jun activation during apoptosis in cerebellar granule neurons.
Shi L, Gong S, Yuan Z, Ma C, Liu Y, Wang C, Li W, Pi R, Huang S, Chen R, Han Y, Mao Z, Li M
Neurosci Lett. 2005
PubMed ID: 15664113
Role for the pleckstrin homology domain-containing protein CKIP-1 in AP-1 regulation and apoptosis.
Zhang L, Xing G, Tie Y, Tang Y, Tian C, Li L, Sun L, Wei H, Zhu Y, He F
EMBO J. 2005
PubMed ID: 15706351
Global gene expression analysis of estrogen receptor transcription factor cross talk in breast cancer: identification of estrogen-induced/activator protein-1-dependent genes.
DeNardo DG, Kim HT, Hilsenbeck S, Cuba V, Tsimelzon A, Brown PH
Mol Endocrinol. 2005
PubMed ID: 15514030
UTP induces osteopontin expression through a coordinate action of NFkappaB, activator protein-1, and upstream stimulatory factor in arterial smooth muscle cells.
Renault MA, Jalvy S, Potier M, Belloc I, Genot E, Dekker LV, Desgranges C, Gadeau AP
J Biol Chem. 2005
PubMed ID: 15557322
MEKK1 regulates the AP-1 dimer repertoire via control of JunB transcription and Fra-2 protein stability.
Cuevas BD, Uhlik MT, Garrington TP, Johnson GL
Oncogene. 2005
PubMed ID: 15558021
Altered pharmacology and distinct coactivator usage for estrogen receptor-dependent transcription through activating protein-1.
Cheung E, Acevedo ML, Cole PA, Kraus WL
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15642950
Substance P mediates AP-1 induction in A549 cells via reactive oxygen species.
Springer J, Pleimes D, Scholz FR, Fischer A
Regul Pept. 2005
PubMed ID: 15544846
c-Jun N-terminal kinase 3 deficiency protects neurons from axotomy-induced death in vivo through mechanisms independent of c-Jun phosphorylation.
Keramaris E, Vanderluit JL, Bahadori M, Mousavi K, Davis RJ, Flavell R, Slack RS, Park DS
J Biol Chem. 2005
PubMed ID: 15528206
Role of selenium in regulation of spermatogenesis: involvement of activator protein 1.
Shalini S, Bansal MP
Biofactors. 2005
PubMed ID: 16410637
Ontogeny of transcription profiles during mouse early craniofacial development.
Karoly ED, Schmid JE, Hunter ES
Reprod Toxicol. 2005
PubMed ID: 15686869
Fos and jun proteins are specifically expressed during differentiation of human keratinocytes.
Mehic D, Bakiri L, Ghannadan M, Wagner EF, Tschachler E
J Invest Dermatol. 2005
PubMed ID: 15654976
Signaling by the kinase MINK is essential in the negative selection of autoreactive thymocytes.
McCarty N, Paust S, Ikizawa K, Dan I, Li X, Cantor H
Nat Immunol. 2005
PubMed ID: 15608642
Induction of the RelB NF-kappaB subunit by the cytomegalovirus IE1 protein is mediated via Jun kinase and c-Jun/Fra-2 AP-1 complexes.
Wang X, Sonenshein GE
J Virol. 2005
PubMed ID: 15596805
YY-1 and c-Jun transcription factors participate in the repression of the human involucrin promoter.
Alvarez-Salas LM, Benitez-Hess ML, Dipaolo JA
Int J Oncol. 2005
PubMed ID: 15586248
Excess biglycan causes eyelid malformation by perturbing muscle development and TGF-alpha signaling.
Hayashi Y, Liu CY, Jester JJ, Hayashi M, Wang IJ, Funderburgh JL, Saika S, Roughley PJ, Kao CW, Kao WW
Dev Biol. 2005
PubMed ID: 15572151
The axon guidance defect of the telencephalic commissures of the JSAP1-deficient brain was partially rescued by the transgenic expression of JIP1.
Ha HY, Cho IH, Lee KW, Lee KW, Song JY, Kim KS, Yu YM, Lee JK, Song JS, Yang SD, Shin HS, Han PL
Dev Biol. 2005
PubMed ID: 15572149
TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation.
He L, Grammer AC, Wu X, Lipsky PE
J Biol Chem. 2004
PubMed ID: 15383523
Mouse brain organization revealed through direct genome-scale TF expression analysis.
Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q
Science. 2004
PubMed ID: 15618518
Induction of mouse c-src in RAW264 cells is dependent on AP-1 and NF-kappaB and important for progression to multinucleated cell formation.
Kumagai N, Ohno K, Tameshige R, Hoshijima M, Yogo K, Ishida N, Takeya T
Biochem Biophys Res Commun. 2004
PubMed ID: 15541355
COBRA1 inhibits AP-1 transcriptional activity in transfected cells.
Zhong H, Zhu J, Zhang H, Ding L, Sun Y, Huang C, Ye Q
Biochem Biophys Res Commun. 2004
PubMed ID: 15530430
Thioredoxin modulates activator protein 1 (AP-1) activity and p27Kip1 degradation through direct interaction with Jab1.
Hwang CY, Ryu YS, Chung MS, Kim KD, Park SS, Chae SK, Chae HZ, Kwon KS
Oncogene. 2004
PubMed ID: 15480426
c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK).
Sevilla A, Santos CR, Barcia R, Vega FM, Lazo PA
Oncogene. 2004
PubMed ID: 15378002
Transcriptional repression of MMP-1 by p21SNFT and reduced in vitro invasiveness of hepatocarcinoma cells.
Bower KE, Fritz JM, McGuire KL
Oncogene. 2004
PubMed ID: 15467742
Reversion of the Jun-induced oncogenic phenotype by enhanced synthesis of sialosyllactosylceramide (GM3 ganglioside).
Miura Y, Kainuma M, Jiang H, Velasco H, Vogt PK, Hakomori S
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15534203
CD14-dependent alterations in c-Jun expression in the liver after burn injury.
Cho K, Adamson LK, Jeong J, Crivello SD, Vanhook TG, Palmieri T, Greenhalgh DG
J Surg Res. 2004
PubMed ID: 15522312
Constitutive expression of the AP-1 transcription factors c-jun, junD, junB, and c-fos and the marginal zone B-cell transcription factor Notch2 in splenic marginal zone lymphoma.
Trøen G, Nygaard V, Jenssen TK, Ikonomou IM, Tierens A, Matutes E, Gruszka-Westwood A, Catovsky D, Myklebost O, Lauritzsen G, Hovig E, Delabie J
J Mol Diagn. 2004
PubMed ID: 15507668
The interaction between GATA proteins and activator protein-1 promotes the transcription of IL-13 in mast cells.
Masuda A, Yoshikai Y, Kume H, Matsuguchi T
J Immunol. 2004
PubMed ID: 15494506
CD99 costimulation up-regulates T cell receptor-mediated activation of JNK and AP-1.
Yoon SS, Kim HJ, Chung DH, Kim TJ
Mol Cells. 2004
PubMed ID: 15528994
c-Jun regulates the stability and activity of the p53 homologue, p73.
Toh WH, Siddique MM, Boominathan L, Lin KW, Sabapathy K
J Biol Chem. 2004
PubMed ID: 15302867
Ubiquitin-mediated fluorescence complementation reveals that Jun ubiquitinated by Itch/AIP4 is localized to lysosomes.
Fang D, Kerppola TK
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15469925
Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch.
Gao M, Labuda T, Xia Y, Gallagher E, Fang D, Liu YC, Karin M
Science. 2004
PubMed ID: 15358865
TRIM45, a novel human RBCC/TRIM protein, inhibits transcriptional activities of ElK-1 and AP-1.
Wang Y, Li Y, Qi X, Yuan W, Ai J, Zhu C, Cao L, Yang H, Liu F, Wu X, Liu M
Biochem Biophys Res Commun. 2004
PubMed ID: 15351693
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
c-Jun-deficient cells undergo premature senescence as a result of spontaneous DNA damage accumulation.
MacLaren A, Black EJ, Clark W, Gillespie DA
Mol Cell Biol. 2004
PubMed ID: 15456874
NF-kappaB- and AP-1-mediated induction of human beta defensin-2 in intestinal epithelial cells by Escherichia coli Nissle 1917: a novel effect of a probiotic bacterium.
Wehkamp J, Harder J, Wehkamp K, Wehkamp-von Meissner B, Schlee M, Enders C, Sonnenborn U, Nuding S, Bengmark S, Fellermann K, Schröder JM, Stange EF
Infect Immun. 2004
PubMed ID: 15385474
Nuclear factor kappaB and activating protein 1 are involved in differentiation-related resistance to oxidative stress in skeletal muscle cells.
Catani MV, Savini I, Duranti G, Caporossi D, Ceci R, Sabatini S, Avigliano L
Free Radic Biol Med. 2004
PubMed ID: 15336319
Roles of p38 and c-jun in the differentiation, proliferation and immortalization of normal human endometrial cells.
Hong IS, Kim SH, Koong MK, Jun JH, Kim SH, Lee YS, Kang KS
Hum Reprod. 2004
PubMed ID: 15333603
Heterodimer formation between c-Jun and Jun B proteins mediated by Epstein-Barr virus encoded latent membrane protein 1.
Song X, Tao YG, Deng XY, Jin X, Tan YN, Tang M, Wu Q, Lee LM, Cao Y
Cell Signal. 2004
PubMed ID: 15240010
Transformation suppressor protein Pdcd4 interferes with JNK-mediated phosphorylation of c-Jun and recruitment of the coactivator p300 by c-Jun.
Bitomsky N, Böhm M, Klempnauer KH
Oncogene. 2004
PubMed ID: 15334056
The c-Jun NH2-terminal kinase is essential for epidermal growth factor expression during epidermal morphogenesis.
Weston CR, Wong A, Hall JP, Goad ME, Flavell RA, Davis RJ
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15375216
Hyper-responsiveness to stimulation of human immunodeficiency virus-infected CD4+ T cells requires Nef and Tat virus gene products and results from higher NFAT, NF-kappaB, and AP-1 induction.
Fortin JF, Barat C, Beauséjour Y, Barbeau B, Tremblay MJ
J Biol Chem. 2004
PubMed ID: 15258149
Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation.
Sabapathy K, Hochedlinger K, Nam SY, Bauer A, Karin M, Wagner EF
Mol Cell. 2004
PubMed ID: 15350216
Tobacco smoke control of mucin production in lung cells requires oxygen radicals AP-1 and JNK.
Gensch E, Gallup M, Sucher A, Li D, Gebremichael A, Lemjabbar H, Mengistab A, Dasari V, Hotchkiss J, Harkema J, Basbaum C
J Biol Chem. 2004
PubMed ID: 15262961
NF-kappaB and AP-1 connection: mechanism of NF-kappaB-dependent regulation of AP-1 activity.
Fujioka S, Niu J, Schmidt C, Sclabas GM, Peng B, Uwagawa T, Li Z, Evans DB, Abbruzzese JL, Chiao PJ
Mol Cell Biol. 2004
PubMed ID: 15314185
Jun blockade of erythropoiesis: role for repression of GATA-1 by HERP2.
Elagib KE, Xiao M, Hussaini IM, Delehanty LL, Palmer LA, Racke FK, Birrer MJ, Shanmugasundaram G, McDevitt MA, Goldfarb AN
Mol Cell Biol. 2004
PubMed ID: 15314183
Mechanical stretch and progesterone differentially regulate activator protein-1 transcription factors in primary rat myometrial smooth muscle cells.
Mitchell JA, Shynlova O, Langille BL, Lye SJ
Am J Physiol Endocrinol Metab. 2004
PubMed ID: 15126239
Human interleukin-5 expression is synergistically regulated by histone acetyltransferase CBP/p300 and transcription factors C/EBP, NF-AT and AP-1.
Liu C, Lu J, Tan J, Li L, Huang B
Cytokine. 2004
PubMed ID: 15271374
Large-scale characterization of HeLa cell nuclear phosphoproteins.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15302935
Inhibition of transcriptional activities of AP-1 and c-Jun by a new zinc finger protein ZNF394.
Huang C, Wang Y, Li D, Li Y, Luo J, Yuan W, Ou Y, Zhu C, Zhang Y, Wang Z, Liu M, Wu X
Biochem Biophys Res Commun. 2004
PubMed ID: 15249231
Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation.
Ikeda F, Nishimura R, Matsubara T, Tanaka S, Inoue J, Reddy SV, Hata K, Yamashita K, Hiraga T, Watanabe T, Kukita T, Yoshioka K, Rao A, Yoneda T
J Clin Invest. 2004
PubMed ID: 15314684
Insulin-mediated activation of activator protein-1 through the mitogen-activated protein kinase pathway stimulates collagenase-1 gene transcription in the MES 13 mesangial cell line.
Ayala JE, Boustead JN, Chapman SC, Svitek CA, Oeser JK, Robey RB, O'Brien RM
J Mol Endocrinol. 2004
PubMed ID: 15291758
JNK regulates autocrine expression of TGF-beta1.
Ventura JJ, Kennedy NJ, Flavell RA, Davis RJ
Mol Cell. 2004
PubMed ID: 15260977
c-Jun and Sp1 family are critical for retinoic acid induction of the lamin A/C retinoic acid-responsive element.
Okumura K, Hosoe Y, Nakajima N
Biochem Biophys Res Commun. 2004
PubMed ID: 15219855
The AP-1 transcription factor c-Jun is required for efficient axonal regeneration.
Raivich G, Bohatschek M, Da Costa C, Iwata O, Galiano M, Hristova M, Nateri AS, Makwana M, Riera-Sans L, Wolfer DP, Lipp HP, Aguzzi A, Wagner EF, Behrens A
Neuron. 2004
PubMed ID: 15233917
Expression of c-Fos and c-Jun in developing mouse lens.
Shirai K, Saika S, Okada Y, Senba E, Ohnishi Y
Ophthalmic Res. 2004
PubMed ID: 15292661
The IkappaB kinase complex and NF-kappaB act as master regulators of lipopolysaccharide-induced gene expression and control subordinate activation of AP-1.
Krappmann D, Wegener E, Sunami Y, Esen M, Thiel A, Mordmuller B, Scheidereit C
Mol Cell Biol. 2004
PubMed ID: 15226448
The effect of LXR activators on AP-1 proteins in keratinocytes.
Schmuth M, Elias PM, Hanley K, Lau P, Moser A, Willson TM, Bikle DD, Feingold KR
J Invest Dermatol. 2004
PubMed ID: 15191540
The basic leucine zipper domain of c-Jun functions in transcriptional activation through interaction with the N terminus of human TATA-binding protein-associated factor-1 (human TAF(II)250).
Lively TN, Nguyen TN, Galasinski SK, Goodrich JA
J Biol Chem. 2004
PubMed ID: 15087451
A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery.
Gherzi R, Lee KY, Briata P, Wegmüller D, Moroni C, Karin M, Chen CY
Mol Cell. 2004
PubMed ID: 15175153
JunD-menin interaction regulates c-Jun-mediated AP-1 transactivation.
Ikeo Y, Yumita W, Sakurai A, Hashizume K
Endocr J. 2004
PubMed ID: 15256779
Activation of the Interleukin-6 promoter by a dominant negative mutant of c-Jun.
Faggioli L, Costanzo C, Donadelli M, Palmieri M
Biochim Biophys Acta. 2004
PubMed ID: 15158360
Activation of the c-Jun transcription factor following neurodegeneration in vivo.
Schenkel J
Neurosci Lett. 2004
PubMed ID: 15135887
Effect of deoxyribozymes targeting c-Jun on solid tumor growth and angiogenesis in rodents.
Zhang G, Dass CR, Sumithran E, Di Girolamo N, Sun LQ, Khachigian LM
J Natl Cancer Inst. 2004
PubMed ID: 15126605
Glucose utilization is essential for hypoxia-inducible factor 1 alpha-dependent phosphorylation of c-Jun.
Laderoute KR, Calaoagan JM, Knapp M, Johnson RS
Mol Cell Biol. 2004
PubMed ID: 15121835
TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis.
Xu LG, Li LY, Shu HB
J Biol Chem. 2004
PubMed ID: 15001576
Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit.
Debril MB, Gelman L, Fayard E, Annicotte JS, Rocchi S, Auwerx J
J Biol Chem. 2004
PubMed ID: 14701856
Inhibition of AP-1 transcription activator induces myc-dependent apoptosis in HL60 cells.
Park S, Hahm ER, Lee DK, Yang CH
J Cell Biochem. 2004
PubMed ID: 15034932
Differential regulation of activator protein-1 and heat shock factor-1 in myocardial ischemia and reperfusion injury: role of poly(ADP-ribose) polymerase-1.
Zingarelli B, Hake PW, O'Connor M, Denenberg A, Wong HR, Kong S, Aronow BJ
Am J Physiol Heart Circ Physiol. 2004
PubMed ID: 14670820
Evidence that C promoter-binding factor 1 binding is required for Notch-1-mediated repression of activator protein-1.
Chu J, Bresnick EH
J Biol Chem. 2004
PubMed ID: 14645224
Ras protects Rb family null fibroblasts from cell death: a role for AP-1.
Young AP, Longmore GD
J Biol Chem. 2004
PubMed ID: 14688262
Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase.
Wertz IE, O'Rourke KM, Zhang Z, Dornan D, Arnott D, Deshaies RJ, Dixit VM
Science. 2004
PubMed ID: 14739464
The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling.
Nateri AS, Riera-Sans L, Da Costa C, Behrens A
Science. 2004
PubMed ID: 14739463
DCX, a new mediator of the JNK pathway.
Gdalyahu A, Ghosh I, Levy T, Sapir T, Sapoznik S, Fishler Y, Azoulai D, Reiner O
EMBO J. 2004
PubMed ID: 14765123
Estrogen receptor inhibits c-Jun-dependent stress-induced cell death by binding and modifying c-Jun activity in human breast cancer cells.
Qi X, Borowicz S, Pramanik R, Schultz RM, Han J, Chen G
J Biol Chem. 2004
PubMed ID: 14638681
H2O2-dependent activation of GCLC-ARE4 reporter occurs by mitogen-activated protein kinase pathways without oxidation of cellular glutathione or thioredoxin-1.
Go YM, Gipp JJ, Mulcahy RT, Jones DP
J Biol Chem. 2004
PubMed ID: 14638694
Krox-20 inhibits Jun-NH2-terminal kinase/c-Jun to control Schwann cell proliferation and death.
Parkinson DB, Bhaskaran A, Droggiti A, Dickinson S, D'Antonio M, Mirsky R, Jessen KR
J Cell Biol. 2004
PubMed ID: 14757751
Induction of myofibroblast MMP-9 transcription in three-dimensional collagen I gel cultures: regulation by NF-kappaB, AP-1 and Sp1.
Takahra T, Smart DE, Oakley F, Mann DA
Int J Biochem Cell Biol. 2004
PubMed ID: 14643899
c-Jun is regulated by combination of enhanced expression and phosphorylation in acute-overloaded rat heart.
Nadruz W, Kobarg CB, Kobarg J, Franchini KG
Am J Physiol Heart Circ Physiol. 2004
PubMed ID: 14512277
Schnurri-3 (KRC) interacts with c-Jun to regulate the IL-2 gene in T cells.
Oukka M, Wein MN, Glimcher LH
J Exp Med. 2004
PubMed ID: 14707112
In vitro selection of Jun-associated proteins using mRNA display.
Horisawa K, Tateyama S, Ishizaka M, Matsumura N, Takashima H, Miyamoto-Sato E, Doi N, Yanagawa H
Nucleic Acids Res. 2004
PubMed ID: 15576676
GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Visel A, Thaller C, Eichele G
Nucleic Acids Res. 2004
PubMed ID: 14681479
Role of p22phox in angiotensin II and platelet-derived growth factor AA induced activator protein 1 activation in vascular smooth muscle cells.
Viedt C, Fei J, Krieger-Brauer HI, Brandes RP, Teupser D, Kamimura M, Katus HA, Kreuzer J
J Mol Med. 2004
PubMed ID: 14652666
Molecular basis for the direct inhibition of AP-1 DNA binding by 15-deoxy-Delta 12,14-prostaglandin J2.
Pérez-Sala D, Cernuda-Morollón E, Cañada FJ
J Biol Chem. 2003
PubMed ID: 14532268
Induction of human methionine adenosyltransferase 2A expression by tumor necrosis factor alpha. Role of NF-kappa B and AP-1.
Yang H, Sadda MR, Yu V, Zeng Y, Lee TD, Ou X, Chen L, Lu SC
J Biol Chem. 2003
PubMed ID: 14530285
ATF3 enhances c-Jun-mediated neurite sprouting.
Pearson AG, Gray CW, Pearson JF, Greenwood JM, During MJ, Dragunow M
Brain Res Mol Brain Res. 2003
PubMed ID: 14667575
The interaction between dHAND and Arix at the dopamine beta-hydroxylase promoter region is independent of direct dHAND binding to DNA.
Rychlik JL, Gerbasi V, Lewis EJ
J Biol Chem. 2003
PubMed ID: 14506227
A promoter within the E6 ORF of human papillomavirus type 16 contributes to the expression of the E7 oncoprotein from a monocistronic mRNA.
Glahder JA, Hansen CN, Vinther J, Madsen BS, Norrild B
J Gen Virol. 2003
PubMed ID: 14645924
Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling.
Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H, Gaynor RB, Matsumoto K
EMBO J. 2003
PubMed ID: 14633987
NF-kappaB and c-Jun-dependent regulation of macrophage inflammatory protein-2 gene expression in response to lipopolysaccharide in RAW 264.7 cells.
Kim DS, Han JH, Kwon HJ
Mol Immunol. 2003
PubMed ID: 14597166
Hypoxia increases AP-1 binding activity by enhancing capacitative Ca2+ entry in human pulmonary artery endothelial cells.
Fantozzi I, Zhang S, Platoshyn O, Remillard CV, Cowling RT, Yuan JX
Am J Physiol Lung Cell Mol Physiol. 2003
PubMed ID: 12909593
Jun activation domain binding protein 1 expression is associated with low p27(Kip1)levels in node-negative breast cancer.
Esteva FJ, Sahin AA, Rassidakis GZ, Yuan LX, Smith TL, Yang Y, Gilcrease MZ, Cristofanilli M, Nahta R, Pusztai L, Claret FX
Clin Cancer Res. 2003
PubMed ID: 14654548
Induction of disease-associated keratin 16 gene expression by epidermal growth factor is regulated through cooperation of transcription factors Sp1 and c-Jun.
Wang YN, Chang WC
J Biol Chem. 2003
PubMed ID: 12954631
MEK kinase 1 regulates c-Jun phosphorylation in the control of corneal morphogenesis.
Zhang L, Deng M, Kao CW, Kao WW, Xia Y
Mol Vis. 2003
PubMed ID: 14627958
Astrocyte protection of neurons: role of transforming growth factor-beta signaling via a c-Jun-AP-1 protective pathway.
Dhandapani KM, Hadman M, De Sevilla L, Wade MF, Mahesh VB, Brann DW
J Biol Chem. 2003
PubMed ID: 12888549
STAT3-dependent enhanceosome assembly and disassembly: synergy with GR for full transcriptional increase of the alpha 2-macroglobulin gene.
Lerner L, Henriksen MA, Zhang X, Darnell JE
Genes Dev. 2003
PubMed ID: 14522952
Inflammatory cytokine expression is independent of the c-Jun N-terminal kinase/AP-1 signaling cascade in human neutrophils.
Cloutier A, Ear T, Borissevitch O, Larivée P, McDonald PP
J Immunol. 2003
PubMed ID: 14500675
Survival regulation in pancreatic cancer cells by c-Jun.
Okutomi Y, Shino Y, Komoda F, Hirano T, Ishihara T, Yamaguchi T, Saisho H, Shirasawa H
Int J Oncol. 2003
PubMed ID: 12963995
Structure of NFAT1 bound as a dimer to the HIV-1 LTR kappa B element.
Giffin MJ, Stroud JC, Bates DL, von Koenig KD, Hardin J, Chen L
Nat Struct Biol. 2003
PubMed ID: 12949493
Expression of dominant negative c-jun inhibits ultraviolet B-induced squamous cell carcinoma number and size in an SKH-1 hairless mouse model.
Cooper SJ, MacGowan J, Ranger-Moore J, Young MR, Colburn NH, Bowden GT
Mol Cancer Res. 2003
PubMed ID: 14517347
A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure.
Zhang L, Wang W, Hayashi Y, Jester JV, Birk DE, Gao M, Liu CY, Kao WW, Karin M, Xia Y
EMBO J. 2003
PubMed ID: 12941696
The gonadotropin releasing hormone (GnRH) receptor activating sequence (GRAS) is a composite regulatory element that interacts with multiple classes of transcription factors including Smads, AP-1 and a forkhead DNA binding protein.
Ellsworth BS, Burns AT, Escudero KW, Duval DL, Nelson SE, Clay CM
Mol Cell Endocrinol. 2003
PubMed ID: 12943993
Decreased AP-1 activity and interleukin-11 expression by bone marrow stromal cells may be associated with impaired bone formation in aged mice.
Tohjima E, Inoue D, Yamamoto N, Kido S, Ito Y, Kato S, Takeuchi Y, Fukumoto S, Matsumoto T
J Bone Miner Res. 2003
PubMed ID: 12929935
AP-1 mediated relief of repressive activity of the CD30 promoter microsatellite in Hodgkin and Reed-Sternberg cells.
Watanabe M, Ogawa Y, Ito K, Higashihara M, Kadin ME, Abraham LJ, Watanabe T, Horie R
Am J Pathol. 2003
PubMed ID: 12875982
Increased expression of c-Jun transcription factor in cerebellar vermis of patients with schizophrenia.
Todorova VK, Elbein AD, Kyosseva SV
Neuropsychopharmacology. 2003
PubMed ID: 12799614
Abnormal phospholipid composition impairs HDL biogenesis and maturation in mice lacking Abca1.
Francone OL, Subbaiah PV, van Tol A, Royer L, Haghpassand M
Biochemistry. 2003
PubMed ID: 12859204
JNK phosphorylation relieves HDAC3-dependent suppression of the transcriptional activity of c-Jun.
Weiss C, Schneider S, Wagner EF, Zhang X, Seto E, Bohmann D
EMBO J. 2003
PubMed ID: 12853483
The role of JNK and p38 MAPK activities in UVA-induced signaling pathways leading to AP-1 activation and c-Fos expression.
Silvers AL, Bachelor MA, Bowden GT
Neoplasia. 2003
PubMed ID: 14511403
Erk pathway and activator protein 1 play crucial roles in FGF2-stimulated premature cranial suture closure.
Kim HJ, Lee MH, Park HS, Park MH, Lee SW, Kim SY, Choi JY, Shin HI, Kim HJ, Ryoo HM
Dev Dyn. 2003
PubMed ID: 12815619
Comprehensive identification of human bZIP interactions with coiled-coil arrays.
Newman JR, Keating AE
Science. 2003
PubMed ID: 12805554
c-jun regulation and function in the developing hindbrain.
Mechta-Grigoriou F, Giudicelli F, Pujades C, Charnay P, Yaniv M
Dev Biol. 2003
PubMed ID: 12798298
TAF7 (TAFII55) plays a role in the transcription activation by c-Jun.
Munz C, Psichari E, Mandilis D, Lavigne AC, Spiliotaki M, Oehler T, Davidson I, Tora L, Angel P, Pintzas A
J Biol Chem. 2003
PubMed ID: 12676957
Androgen and the blocking of radiation-induced sensitization to Fas-mediated apoptosis through c-jun induction in prostate cancer cells.
Shimada K, Nakamura M, Ishida E, Kishi M, Konishi N
Int J Radiat Biol. 2003
PubMed ID: 12963547
Apoptosis-signal regulating kinase-1 is involved in the low potassium-induced activation of p38 mitogen-activated protein kinase and c-Jun in cultured cerebellar granule neurons.
Yamagishi S, Yamada M, Koshimizu H, Takai S, Hatanaka H, Takeda K, Ichijo H, Shimoke K, Ikeuchi T
J Biochem. 2003
PubMed ID: 12869527
c-Jun regulates eyelid closure and skin tumor development through EGFR signaling.
Zenz R, Scheuch H, Martin P, Frank C, Eferl R, Kenner L, Sibilia M, Wagner EF
Dev Cell. 2003
PubMed ID: 12791272
c-Jun is essential for organization of the epidermal leading edge.
Li G, Gustafson-Brown C, Hanks SK, Nason K, Arbeit JM, Pogliano K, Wisdom RM, Johnson RS
Dev Cell. 2003
PubMed ID: 12791271
Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes.
Galey D, Becker K, Haughey N, Kalehua A, Taub D, Woodward J, Mattson MP, Nath A
J Neurovirol. 2003
PubMed ID: 12775419
Alterations in the DNA binding activity of transcriptional factors activator protein-1, Sp1, and hepatocyte nuclear factor-1 in rat jejunum during starvation and refeeding.
Ihara T, Tsujikawa T, Fujiyama Y, Bamba T
J Gastroenterol Hepatol. 2003
PubMed ID: 12753154
Ras and mitogen-activated protein kinase kinase kinase-1 coregulate activator protein-1- and nuclear factor-kappaB-mediated gene expression in airway epithelial cells.
Zhou L, Tan A, Iasvovskaia S, Li J, Lin A, Hershenson MB
Am J Respir Cell Mol Biol. 2003
PubMed ID: 12600818
Characterization of human constitutive photomorphogenesis protein 1, a RING finger ubiquitin ligase that interacts with Jun transcription factors and modulates their transcriptional activity.
Bianchi E, Denti S, Catena R, Rossetti G, Polo S, Gasparian S, Putignano S, Rogge L, Pardi R
J Biol Chem. 2003
PubMed ID: 12615916
JNK initiates a cytokine cascade that causes Pax2 expression and closure of the optic fissure.
Weston CR, Wong A, Hall JP, Goad ME, Flavell RA, Davis RJ
Genes Dev. 2003
PubMed ID: 12756228
Identification of cJun-responsive genes in Rat-1a cells using multiple techniques: increased expression of stathmin is necessary for cJun-mediated anchorage-independent growth.
Kinoshita I, Leaner V, Katabami M, Manzano RG, Dent P, Sabichi A, Birrer MJ
Oncogene. 2003
PubMed ID: 12743595
Members of the AP-1 family, c-Jun and c-Fos, functionally interact with JC virus early regulatory protein large T antigen.
Kim J, Woolridge S, Biffi R, Borghi E, Lassak A, Ferrante P, Amini S, Khalili K, Safak M
J Virol. 2003
PubMed ID: 12692226
Critical role of the transcription factor AP-1 for the constitutive and interferon-induced expression of IFI 16.
Clarke CJ, Apostolidis V, Hii LL, Gough DJ, Trapani JA, Johnstone RW
J Cell Biochem. 2003
PubMed ID: 12682910
Downregulation of c-Jun expression and cell cycle regulatory molecules in acute myeloid leukemia cells upon CD44 ligation.
Zada AA, Singh SM, Reddy VA, Elsässer A, Meisel A, Haferlach T, Tenen DG, Hiddemann W, Behre G
Oncogene. 2003
PubMed ID: 12700665
Tumor promoter arsenite stimulates histone H3 phosphoacetylation of proto-oncogenes c-fos and c-jun chromatin in human diploid fibroblasts.
Li J, Gorospe M, Barnes J, Liu Y
J Biol Chem. 2003
PubMed ID: 12547826
Expression of AP-1 (c-fos/c-jun) in developing mouse corneal epithelium.
Okada Y, Saika S, Shirai K, Ohnishi Y, Senba E
Graefes Arch Clin Exp Ophthalmol. 2003
PubMed ID: 12719996
An unexpected role for FosB in activation-induced cell death of T cells.
Baumann S, Hess J, Eichhorst ST, Krueger A, Angel P, Krammer PH, Kirchhoff S
Oncogene. 2003
PubMed ID: 12618758
ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a.
Wen-Sheng W
Oncogene. 2003
PubMed ID: 12592382
Simulated microgravity suppresses osteoblast phenotype, Runx2 levels and AP-1 transactivation.
Ontiveros C, McCabe LR
J Cell Biochem. 2003
PubMed ID: 12532319
Receptor-interacting protein 140 binds c-Jun and inhibits estradiol-induced activator protein-1 activity by reversing glucocorticoid receptor-interacting protein 1 effect.
Teyssier C, Belguise K, Galtier F, Cavailles V, Chalbos D
Mol Endocrinol. 2003
PubMed ID: 12554755
Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53.
Eferl R, Ricci R, Kenner L, Zenz R, David JP, Rath M, Wagner EF
Cell. 2003
PubMed ID: 12553907
Exogenous Nef protein activates NF-kappa B, AP-1, and c-Jun N-terminal kinase and stimulates HIV transcription in promonocytic cells. Role in AIDS pathogenesis.
Varin A, Manna SK, Quivy V, Decrion AZ, Van Lint C, Herbein G, Aggarwal BB
J Biol Chem. 2003
PubMed ID: 12419805
POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis.
Xu Z, Kukekov NV, Greene LA
EMBO J. 2003
PubMed ID: 12514131
HIV-Tat protein induces oxidative and inflammatory pathways in brain endothelium.
Toborek M, Lee YW, Pu H, Malecki A, Flora G, Garrido R, Hennig B, Bauer HC, Nath A
J Neurochem. 2003
PubMed ID: 12485413
Impaired intervertebral disc formation in the absence of Jun.
Behrens A, Haigh J, Mechta-Grigoriou F, Nagy A, Yaniv M, Wagner EF
Development. 2003
PubMed ID: 12441295
ATF1 phosphorylation by the ERK MAPK pathway is required for epidermal growth factor-induced c-jun expression.
Gupta P, Prywes R
J Biol Chem. 2002
PubMed ID: 12414794
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Estrogen receptor alpha and activating protein-1 mediate estrogen responsiveness of the progesterone receptor gene in MCF-7 breast cancer cells.
Petz LN, Ziegler YS, Loven MA, Nardulli AM
Endocrinology. 2002
PubMed ID: 12446585
Structurally distinct modes of recognition of the KIX domain of CBP by Jun and CREB.
Campbell KM, Lumb KJ
Biochemistry. 2002
PubMed ID: 12437352
Increased expression and activation of c-Jun contributes to human amylin-induced apoptosis in pancreatic islet beta-cells.
Zhang S, Liu J, MacGibbon G, Dragunow M, Cooper GJ
J Mol Biol. 2002
PubMed ID: 12441106
JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanisms.
David JP, Sabapathy K, Hoffmann O, Idarraga MH, Wagner EF
J Cell Sci. 2002
PubMed ID: 12376563
A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria.
Wiltshire C, Matsushita M, Tsukada S, Gillespie DA, May GH
Biochem J. 2002
PubMed ID: 12167088
SEK1/MKK4-mediated SAPK/JNK signaling participates in embryonic hepatoblast proliferation via a pathway different from NF-kappaB-induced anti-apoptosis.
Watanabe T, Nakagawa K, Ohata S, Kitagawa D, Nishitai G, Seo J, Tanemura S, Shimizu N, Kishimoto H, Wada T, Aoki J, Arai H, Iwatsubo T, Mochita M, Watanabe T, Satake M, Ito Y, Matsuyama T, Mak TW, Penninger JM, Nishina H, Katada T
Dev Biol. 2002
PubMed ID: 12376107
SUMO-1 protease-1 regulates gene transcription through PML.
Best JL, Ganiatsas S, Agarwal S, Changou A, Salomoni P, Shirihai O, Meluh PB, Pandolfi PP, Zon LI
Mol Cell. 2002
PubMed ID: 12419228
Correlation of transcriptional repression by p21(SNFT) with changes in DNA.NF-AT complex interactions.
Bower KE, Zeller RW, Wachsman W, Martinez T, McGuire KL
J Biol Chem. 2002
PubMed ID: 12087103
Jab1 co-activation of c-Jun is abrogated by the serine 10-phosphorylated form of p27Kip1.
Chopra S, Fernandez De Mattos S, Lam EW, Mann DJ
J Biol Chem. 2002
PubMed ID: 12119282
Epstein-Barr virus latent membrane protein 2A regulates c-Jun protein through extracellular signal-regulated kinase.
Chen SY, Lu J, Shih YC, Tsai CH
J Virol. 2002
PubMed ID: 12186939
Regulation of two JunD isoforms by Jun N-terminal kinases.
Yazgan O, Pfarr CM
J Biol Chem. 2002
PubMed ID: 12052834
A novel transactivating factor that regulates interferon-gamma-dependent gene expression.
Hu J, Meng Q, Roy SK, Raha A, Hu J, Zhang J, Hashimoto K, Kalvakolanu DV
J Biol Chem. 2002
PubMed ID: 12050152
Repression of AP-1 function: a mechanism for the regulation of Blimp-1 expression and B lymphocyte differentiation by the B cell lymphoma-6 protooncogene.
Vasanwala FH, Kusam S, Toney LM, Dent AL
J Immunol. 2002
PubMed ID: 12165517
c-Jun associates with the oncoprotein Ski and suppresses Smad2 transcriptional activity.
Pessah M, Marais J, Prunier C, Ferrand N, Lallemand F, Mauviel A, Atfi A
J Biol Chem. 2002
PubMed ID: 12034730
c-jun is essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation.
Palmada M, Kanwal S, Rutkoski NJ, Gustafson-Brown C, Johnson RS, Wisdom R, Carter BD, Gufstafson-Brown C
J Cell Biol. 2002
PubMed ID: 12163468
Transcriptional activation of C/EBPbeta gene by c-Jun and ATF2.
Lin WC, Shen BJ, Tsay YG, Yen HC, Lee SC, Chang CJ
DNA Cell Biol. 2002
PubMed ID: 12215258
Cell stress and MEKK1-mediated c-Jun activation modulate NFkappaB activity and cell viability.
Sánchez-Pérez I, Benitah SA, Martínez-Gomariz M, Lacal JC, Perona R
Mol Biol Cell. 2002
PubMed ID: 12181357
Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B.
Mathas S, Hinz M, Anagnostopoulos I, Krappmann D, Lietz A, Jundt F, Bommert K, Mechta-Grigoriou F, Stein H, Dörken B, Scheidereit C
EMBO J. 2002
PubMed ID: 12145210
Chronic antipsychotic drug treatment induces long-lasting expression of fos and jun family genes and activator protein 1 complex in the rat prefrontal cortex.
Kontkanen O, Lakso M, Wong G, Castrén E
Neuropsychopharmacology. 2002
PubMed ID: 12093589
Granulocyte inducer C/EBPalpha inactivates the myeloid master regulator PU.1: possible role in lineage commitment decisions.
Reddy VA, Iwama A, Iotzova G, Schulz M, Elsasser A, Vangala RK, Tenen DG, Hiddemann W, Behre G
Blood. 2002
PubMed ID: 12091339
HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replication.
Cicala C, Arthos J, Selig SM, Dennis G, Hosack DA, Van Ryk D, Spangler ML, Steenbeke TD, Khazanie P, Gupta N, Yang J, Daucher M, Lempicki RA, Fauci AS
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12089333
Novel transcription coactivator complex containing activating signal cointegrator 1.
Jung DJ, Sung HS, Goo YW, Lee HM, Park OK, Jung SY, Lim J, Kim HJ, Lee SK, Kim TS, Lee JW, Lee YC
Mol Cell Biol. 2002
PubMed ID: 12077347
Promoter specificity and biological activity of tethered AP-1 dimers.
Bakiri L, Matsuo K, Wisniewska M, Wagner EF, Yaniv M
Mol Cell Biol. 2002
PubMed ID: 12052899
Retinoic acid receptors inhibit AP1 activation by regulating extracellular signal-regulated kinase and CBP recruitment to an AP1-responsive promoter.
Benkoussa M, Brand C, Delmotte MH, Formstecher P, Lefebvre P
Mol Cell Biol. 2002
PubMed ID: 12052862
Activation of human monoamine oxidase B gene expression by a protein kinase C MAPK signal transduction pathway involves c-Jun and Egr-1.
Wong WK, Ou XM, Chen K, Shih JC
J Biol Chem. 2002
PubMed ID: 11956220
c-Jun regulates vascular smooth muscle cell growth and neointima formation after arterial injury. Inhibition by a novel DNA enzyme targeting c-Jun.
Khachigian LM, Fahmy RG, Zhang G, Bobryshev YV, Kaniaros A
J Biol Chem. 2002
PubMed ID: 11891228
JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction.
Hu YF, Li R
Genes Dev. 2002
PubMed ID: 12080089
Molecular mechanism of transforming growth factor (TGF)-beta1-induced glutathione depletion in alveolar epithelial cells. Involvement of AP-1/ARE and Fra-1.
Jardine H, MacNee W, Donaldson K, Rahman I
J Biol Chem. 2002
PubMed ID: 11912197
Identification of a substrate recognition site on Ubc9.
Lin D, Tatham MH, Yu B, Kim S, Hay RT, Chen Y
J Biol Chem. 2002
PubMed ID: 11877416
A dominant negative c-jun specifically blocks okadaic acid-induced skin tumor promotion.
Thompson EJ, MacGowan J, Young MR, Colburn N, Bowden GT
Cancer Res. 2002
PubMed ID: 12036911
Analysis of heterophilic and homophilic interactions of cadherins using the c-Jun/c-Fos dimerization domains.
Ahrens T, Pertz O, Haussinger D, Fauser C, Schulthess T, Engel J
J Biol Chem. 2002
PubMed ID: 11909859
Mitogen-activated protein kinases and activator protein 1 are required for proliferation and cardiomyocyte differentiation of P19 embryonal carcinoma cells.
Eriksson M, Leppä S
J Biol Chem. 2002
PubMed ID: 11884386
[Possible role of transcription factor AP1 in the tissue-specific regulation of human papillomavirus]
Velazquez Torres A, Gariglio Vidal P
Rev Invest Clin. 2002
PubMed ID: 12183893
Amino-terminal phosphorylation of c-Jun regulates apoptosis in the retinal ganglion cells by optic nerve transection.
Yoshida K, Behrens A, Le-Niculescu H, Wagner EF, Harada T, Imaki J, Ohno S, Karin M
Invest Ophthalmol Vis Sci. 2002
PubMed ID: 11980884
Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver.
Behrens A, Sibilia M, David JP, Möhle-Steinlein U, Tronche F, Schütz G, Wagner EF
EMBO J. 2002
PubMed ID: 11927562
Visualization of interactions among bZIP and Rel family proteins in living cells using bimolecular fluorescence complementation.
Hu CD, Chinenov Y, Kerppola TK
Mol Cell. 2002
PubMed ID: 11983170
The response of c-jun/AP-1 to chronic hypoxia is hypoxia-inducible factor 1 alpha dependent.
Laderoute KR, Calaoagan JM, Gustafson-Brown C, Knapp AM, Li GC, Mendonca HL, Ryan HE, Wang Z, Johnson RS
Mol Cell Biol. 2002
PubMed ID: 11909946
An alternative model of H ferritin promoter transactivation by c-Jun.
Faniello MC, Chirico G, Quaresima B, Cuda G, Allevato G, Bevilacqua MA, Baudi F, Colantuoni V, Cimino F, Venuta S, Avvedimento VE, Costanzo F
Biochem J. 2002
PubMed ID: 11903046
AP-1 transrepressing retinoic acid does not deplete coactivators or AP-1 monomers but may target specific Jun or Fos containing dimers.
Suzukawa K, Colburn NH
Oncogene. 2002
PubMed ID: 11948401
Protein kinase D complexes with C-Jun N-terminal kinase via activation loop phosphorylation and phosphorylates the C-Jun N-terminus.
Hurd C, Waldron RT, Rozengurt E
Oncogene. 2002
PubMed ID: 11948398
Bombesin antagonists inhibit growth of MDA-MB-435 estrogen-independent breast cancers and decrease the expression of the ErbB-2/HER-2 oncoprotein and c-jun and c-fos oncogenes.
Bajo AM, Schally AV, Krupa M, Hebert F, Groot K, Szepeshazi K
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11891317
Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity.
Schmidt D, Müller S
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11867732
Functional role of extracellular signal-regulated kinase activation and c-Jun induction in phorbol ester-induced promoter activation of human 12(S)-lipoxygenase gene.
Chen BK, Tsai TY, Huang HS, Chen LC, Chang WC, Tsai SB, Chang WC
J Biomed Sci. 2002
PubMed ID: 11914583
The Wnt antagonist Dickkopf-1 is regulated by Bmp signaling and c-Jun and modulates programmed cell death.
Grotewold L, Rüther U
EMBO J. 2002
PubMed ID: 11867524
Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation.
Fang D, Elly C, Gao B, Fang N, Altman Y, Joazeiro C, Hunter T, Copeland N, Jenkins N, Liu YC
Nat Immunol. 2002
PubMed ID: 11828324
C-Jun modulates apoptosis but not terminal cell differentiation in murine erythroleukemia cells.
Poindessous-Jazat V, Augery-Bourget Y, Robert-Lézénès J
Leukemia. 2002
PubMed ID: 11840290
The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun-activated transcription.
Westermarck J, Weiss C, Saffrich R, Kast J, Musti AM, Wessely M, Ansorge W, Séraphin B, Wilm M, Valdez BC, Bohmann D
EMBO J. 2002
PubMed ID: 11823437
JunB can substitute for Jun in mouse development and cell proliferation.
Passegué E, Jochum W, Behrens A, Ricci R, Wagner EF
Nat Genet. 2002
PubMed ID: 11818961
Tlag2, an N-methyl-N-nitrosourea susceptibility locus, maps to mouse chromosome 4.
Angel JM, Richie ER
Mol Carcinog. 2002
PubMed ID: 11813303
Synergy of IL-12 and IL-18 for IFN-gamma gene expression: IL-12-induced STAT4 contributes to IFN-gamma promoter activation by up-regulating the binding activity of IL-18-induced activator protein 1.
Nakahira M, Ahn HJ, Park WR, Gao P, Tomura M, Park CS, Hamaoka T, Ohta T, Kurimoto M, Fujiwara H
J Immunol. 2002
PubMed ID: 11801649
Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors.
Jung DJ, Na SY, Na DS, Lee JW
J Biol Chem. 2002
PubMed ID: 11704680
Physical interaction of the activator protein-1 factors c-Fos and c-Jun with Cbfa1 for collagenase-3 promoter activation.
D'Alonzo RC, Selvamurugan N, Karsenty G, Partridge NC
J Biol Chem. 2002
PubMed ID: 11641401
Transcriptional regulation of dentin matrix protein 1 (DMP1) by AP-1 (c-fos/c-jun) factors.
Narayanan K, Ramachandran A, Hao J, George A
Connect Tissue Res. 2002
PubMed ID: 12489182
ARAP1: a point of convergence for Arf and Rho signaling.
Miura K, Jacques KM, Stauffer S, Kubosaki A, Zhu K, Hirsch DS, Resau J, Zheng Y, Randazzo PA
Mol Cell. 2002
PubMed ID: 11804590
c-Jun and hypoxia-inducible factor 1 functionally cooperate in hypoxia-induced gene transcription.
Alfranca A, Gutiérrez MD, Vara A, Aragonés J, Vidal F, Landázuri MO
Mol Cell Biol. 2002
PubMed ID: 11739718
UNC-16, a JNK-signaling scaffold protein, regulates vesicle transport in C. elegans.
Byrd DT, Kawasaki M, Walcoff M, Hisamoto N, Matsumoto K, Jin Y
Neuron. 2001
PubMed ID: 11738026
Independent dynamic regulation of histone phosphorylation and acetylation during immediate-early gene induction.
Thomson S, Clayton AL, Mahadevan LC
Mol Cell. 2001
PubMed ID: 11779499
Skin-derived nerve growth factor blocks programmed cell death in the trigeminal ganglia but does not enhance neuron proliferation.
Figueiredo HF, Davis BM, Albers KM
Mech Dev. 2001
PubMed ID: 11731234
Interaction of AP-1 with a cluster of NF-kappa B binding elements in the human TNF promoter region.
Udalova IA, Kwiatkowski D
Biochem Biophys Res Commun. 2001
PubMed ID: 11708771
Functional interaction of Jun and homeodomain proteins.
Schaefer LK, Wang S, Schaefer TS
J Biol Chem. 2001
PubMed ID: 11551904
A specific lysine in c-Jun is required for transcriptional repression by E1A and is acetylated by p300.
Vries RG, Prudenziati M, Zwartjes C, Verlaan M, Kalkhoven E, Zantema A
EMBO J. 2001
PubMed ID: 11689449
Induction of c-jun and TGF-beta 1 in Fischer 344 rats during amiodarone-induced pulmonary fibrosis.
Chung WH, Bennett BM, Racz WJ, Brien JF, Massey TE
Am J Physiol Lung Cell Mol Physiol. 2001
PubMed ID: 11597910
Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death.
Tada K, Okazaki T, Sakon S, Kobarai T, Kurosawa K, Yamaoka S, Hashimoto H, Mak TW, Yagita H, Okumura K, Yeh WC, Nakano H
J Biol Chem. 2001
PubMed ID: 11479302
Characterization of the physical interaction between estrogen receptor alpha and JUN proteins.
Teyssier C, Belguise K, Galtier F, Chalbos D
J Biol Chem. 2001
PubMed ID: 11477071
c-Jun decreases voltage-gated K(+) channel activity in pulmonary artery smooth muscle cells.
Yu Y, Platoshyn O, Zhang J, Krick S, Zhao Y, Rubin LJ, Rothman A, Yuan JX
Circulation. 2001
PubMed ID: 11571252
Ten ERK-related proteins in three distinct classes associate with AP-1 proteins and/or AP-1 DNA.
Kumar NV, Bernstein LR
J Biol Chem. 2001
PubMed ID: 11431474
Inhibition of AP-1 by the glucocorticoid-inducible protein GILZ.
Mittelstadt PR, Ashwell JD
J Biol Chem. 2001
PubMed ID: 11397794
Smad proteins and hepatocyte growth factor control parallel regulatory pathways that converge on beta1-integrin to promote normal liver development.
Weinstein M, Monga SP, Liu Y, Brodie SG, Tang Y, Li C, Mishra L, Deng CX
Mol Cell Biol. 2001
PubMed ID: 11438667
Impaired activation of AP-1 and altered expression of constituent proteins in rat adrenal during ageing.
Medicherla R, Leers-Sucheta S, Luo Y, Azhar S
Mech Ageing Dev. 2001
PubMed ID: 11389931
HIV Tat activates c-Jun amino-terminal kinase through an oxidant-dependent mechanism.
Gu Y, Wu RF, Xu YC, Flores SC, Terada LS
Virology. 2001
PubMed ID: 11448159
c-Jun binds the N terminus of human TAF(II)250 to derepress RNA polymerase II transcription in vitro.
Lively TN, Ferguson HA, Galasinski SK, Seto AG, Goodrich JA
J Biol Chem. 2001
PubMed ID: 11316804
Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1.
Wulf GM, Ryo A, Wulf GG, Lee SW, Niu T, Petkova V, Lu KP
EMBO J. 2001
PubMed ID: 11432833
AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite element.
Hess J, Porte D, Munz C, Angel P
J Biol Chem. 2001
PubMed ID: 11274169
c-Jun interacts with the corepressor TG-interacting factor (TGIF) to suppress Smad2 transcriptional activity.
Pessah M, Prunier C, Marais J, Ferrand N, Mazars A, Lallemand F, Gauthier JM, Atfi A
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11371641
Identification of amino acid residues in the ETS transcription factor Erg that mediate Erg-Jun/Fos-DNA ternary complex formation.
Verger A, Buisine E, Carrère S, Wintjens R, Flourens A, Coll J, Stéhelin D, Duterque-Coquillaud M
J Biol Chem. 2001
PubMed ID: 11278640
PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic.
Crump CM, Xiang Y, Thomas L, Gu F, Austin C, Tooze SA, Thomas G
EMBO J. 2001
PubMed ID: 11331585
Antibodies against c-Jun N-terminal peptide cross-react with neo-epitopes emerging after caspase-mediated proteolysis during apoptosis.
Casas C, Ribera J, Esquerda JE
J Neurochem. 2001
PubMed ID: 11331419
Vav-Rac1-mediated activation of the c-Jun N-terminal kinase/c-Jun/AP-1 pathway plays a major role in stimulation of the distal NFAT site in the interleukin-2 gene promoter.
Kaminuma O, Deckert M, Elly C, Liu YC, Altman A
Mol Cell Biol. 2001
PubMed ID: 11287617
Molecular regulation of the endothelin-1 gene by hypoxia. Contributions of hypoxia-inducible factor-1, activator protein-1, GATA-2, AND p300/CBP.
Yamashita K, Discher DJ, Hu J, Bishopric NH, Webster KA
J Biol Chem. 2001
PubMed ID: 11278891
Role of ATM in oxidative stress-mediated c-Jun phosphorylation in response to ionizing radiation and CdCl2.
Lee SA, Dritschilo A, Jung M
J Biol Chem. 2001
PubMed ID: 11278277
HIV-1 Tat inhibits IL-2 gene transcription through qualitative and quantitative alterations of the cooperative Rel/AP1 complex bound to the CD28RE/AP1 composite element of the IL-2 promoter.
González E, Punzón C, González M, Fresno M
J Immunol. 2001
PubMed ID: 11254713
Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release.
Whitfield J, Neame SJ, Paquet L, Bernard O, Ham J
Neuron. 2001
PubMed ID: 11301023
Extracellular Tat activates c-fos promoter in low serum-starved CD4+ T cells.
Gibellini D, Re MC, Ponti C, Celeghini C, Melloni E, La Placa M, Zauli G
Br J Haematol. 2001
PubMed ID: 11260070
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation.
Sabapathy K, Kallunki T, David JP, Graef I, Karin M, Wagner EF
J Exp Med. 2001
PubMed ID: 11157052
Identification of SWI.SNF complex subunit BAF60a as a determinant of the transactivation potential of Fos/Jun dimers.
Ito T, Yamauchi M, Nishina M, Yamamichi N, Mizutani T, Ui M, Murakami M, Iba H
J Biol Chem. 2001
PubMed ID: 11053448
Regulation of connexin43 expression by c-fos and c-jun in myometrial cells.
Mitchell JA, Lye SJ
Cell Commun Adhes. 2001
PubMed ID: 12064606
The differential molecular mechanisms underlying proenkephalin mRNA expression induced by forskolin and phorbol-12-myristic-13-acetate in primary cultured astrocytes.
Won JS, Suh HW
Brain Res Mol Brain Res. 2000
PubMed ID: 11113530
[Effects of fluoride on the expression of c-fos and c-jun genes and cell proliferation of rat osteoblasts]
Chen L, Tong A, Yu D, Chen R
Zhonghua Yu Fang Yi Xue Za Zhi. 2000
PubMed ID: 11860940
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
H(2)O(2)-induced egr-1, fra-1, and c-jun gene expression is mediated by tyrosine kinase in aortic smooth muscle cells.
Jin N, Hatton ND, Harrington MA, Xia X, Larsen SH, Rhoades RA
Free Radic Biol Med. 2000
PubMed ID: 11053775
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Circadian binding activity of AP-1, a regulator of the arylalkylamine N-acetyltransferase gene in the rat pineal gland, depends on circadian Fra-2, c-Jun, and Jun-D expression and is regulated by the clock's zeitgebers.
Guillaumond F, Sage D, Deprez P, Bosler O, Becquet D, François-Bellan AM
J Neurochem. 2000
PubMed ID: 10987819
Hypomethylation and overexpression of c-jun and c-myc protooncogenes and increased DNA methyltransferase activity in dichloroacetic and trichloroacetic acid-promoted mouse liver tumors.
Tao L, Yang S, Xie M, Kramer PM, Pereira MA
Cancer Lett. 2000
PubMed ID: 10960769
Tumor necrosis factor-alpha inhibits transforming growth factor-beta /Smad signaling in human dermal fibroblasts via AP-1 activation.
Verrecchia F, Pessah M, Atfi A, Mauviel A
J Biol Chem. 2000
PubMed ID: 10903323
Genetic dissection of a rat model for rheumatoid arthritis: significant gender influences on autosomal modifier loci.
Furuya T, Salstrom JL, McCall-Vining S, Cannon GW, Joe B, Remmers EF, Griffiths MM, Wilder RL
Hum Mol Genet. 2000
PubMed ID: 11001927
Functional interaction between c-Jun and promoter factor Sp1 in epidermal growth factor-induced gene expression of human 12(S)-lipoxygenase.
Chen BK, Chang WC
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10973489
Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein.
Iacobelli M, Wachsman W, McGuire KL
J Immunol. 2000
PubMed ID: 10878360
The homeodomain protein Barx2 contains activator and repressor domains and interacts with members of the CREB family.
Edelman DB, Meech R, Jones FS
J Biol Chem. 2000
PubMed ID: 10781615
Differential transcriptional regulation of the monocyte-chemoattractant protein-1 (MCP-1) gene in tumorigenic and non-tumorigenic HPV 18 positive cells: the role of the chromatin structure and AP-1 composition.
Finzer P, Soto U, Delius H, Patzelt A, Coy JF, Poustka A, zur Hausen H, Rösl F
Oncogene. 2000
PubMed ID: 10918580
Hepatocyte migration during liver development requires Prox1.
Sosa-Pineda B, Wigle JT, Oliver G
Nat Genet. 2000
PubMed ID: 10888866
Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2.
Lee SK, Na SY, Jung SY, Choi JE, Jhun BH, Cheong J, Meltzer PS, Lee YC, Lee JW
Mol Endocrinol. 2000
PubMed ID: 10847592
Basic fibroblast growth factor stimulates collagenase-3 promoter activity in osteoblasts through an activator protein-1-binding site.
Varghese S, Rydziel S, Canalis E
Endocrinology. 2000
PubMed ID: 10830307
Differential requirement for p56lck in HIV-tat versus TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal kinase, and apoptosis.
Manna SK, Aggarwal BB
J Immunol. 2000
PubMed ID: 10799874
Sequential increase in Egr-1 and AP-1 DNA binding activity in the dentate gyrus following the induction of long-term potentiation.
Williams JM, Beckmann AM, Mason-Parker SE, Abraham WC, Wilce PA, Tate WP
Brain Res Mol Brain Res. 2000
PubMed ID: 10837920
c-Jun and p53 activity is modulated by SUMO-1 modification.
Muller S, Berger M, Lehembre F, Seeler JS, Haupt Y, Dejean A
J Biol Chem. 2000
PubMed ID: 10788439
Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor.
Lee SK, Kim JH, Lee YC, Cheong J, Lee JW
J Biol Chem. 2000
PubMed ID: 10777532
The human immunodeficiency virus type 1 Tat protein up-regulates the promoter activity of the beta-chemokine monocyte chemoattractant protein 1 in the human astrocytoma cell line U-87 MG: role of SP-1, AP-1, and NF-kappaB consensus sites.
Lim SP, Garzino-Demo A
J Virol. 2000
PubMed ID: 10644332
A nuclear tyrosine phosphorylation circuit: c-Jun as an activator and substrate of c-Abl and JNK.
Barilá D, Mangano R, Gonfloni S, Kretzschmar J, Moro M, Bohmann D, Superti-Furga G
EMBO J. 2000
PubMed ID: 10637231
Marek's disease herpesvirus transforming protein MEQ: a c-Jun analogue with an alternative life style.
Liu JL, Kung HJ
Virus Genes. 2000
PubMed ID: 11022789
c-Jun contributes to amyloid beta-induced neuronal apoptosis but is not necessary for amyloid beta-induced c-jun induction.
Kihiko ME, Tucker HM, Rydel RE, Estus S
J Neurochem. 1999
PubMed ID: 10582624
NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase.
Pomerantz JL, Baltimore D
EMBO J. 1999
PubMed ID: 10581243
A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo.
Lee SK, Anzick SL, Choi JE, Bubendorf L, Guan XY, Jung YK, Kallioniemi OP, Kononen J, Trent JM, Azorsa D, Jhun BH, Cheong JH, Lee YC, Meltzer PS, Lee JW
J Biol Chem. 1999
PubMed ID: 10567404
The role of human MBF1 as a transcriptional coactivator.
Kabe Y, Goto M, Shima D, Imai T, Wada T, Morohashi K, Shirakawa M, Hirose S, Handa H
J Biol Chem. 1999
PubMed ID: 10567391
HIV-1 gp120 envelope protein modulates proliferation of human glomerular epithelial cells.
Singhal PC, Reddy K, Franki N, Ding G
J Cell Biochem. 1999
PubMed ID: 10581001
CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins.
Ubeda M, Vallejo M, Habener JF
Mol Cell Biol. 1999
PubMed ID: 10523647
c-Jun transactivates the promoter of the human p21(WAF1/Cip1) gene by acting as a superactivator of the ubiquitous transcription factor Sp1.
Kardassis D, Papakosta P, Pardali K, Moustakas A
J Biol Chem. 1999
PubMed ID: 10506225
Liver gene disruptions: winners by KO?
Smith AJ, Oude Elferink RP
J Hepatol. 1999
PubMed ID: 10551403
Bcl3, an IkappaB protein, stimulates activating protein-1 transactivation and cellular proliferation.
Na SY, Choi JE, Kim HJ, Jhun BH, Lee YC, Lee JW
J Biol Chem. 1999
PubMed ID: 10497212
Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation.
Zhang X, Wrzeszczynska MH, Horvath CM, Darnell JE
Mol Cell Biol. 1999
PubMed ID: 10490649
ERK MAP kinase links cytokine signals to activation of latent HIV-1 infection by stimulating a cooperative interaction of AP-1 and NF-kappaB.
Yang X, Chen Y, Gabuzda D
J Biol Chem. 1999
PubMed ID: 10488148
Extracellular HIV-1 Tat protein differentially activates the JNK and ERK/MAPK pathways in CD4 T cells.
Mischiati C, Pironi F, Milani D, Giacca M, Mirandola P, Capitani S, Zauli G
AIDS. 1999
PubMed ID: 10509564
Function of steroidogenic factor 1 domains in nuclear localization, transactivation, and interaction with transcription factor TFIIB and c-Jun.
Li LA, Chiang EF, Chen JC, Hsu NC, Chen YJ, Chung BC
Mol Endocrinol. 1999
PubMed ID: 10478848
Retinoid-dependent recruitment of a histone H1 displacement activity by retinoic acid receptor.
Nagpal S, Ghosn C, DiSepio D, Molina Y, Sutter M, Klein ES, Chandraratna RA
J Biol Chem. 1999
PubMed ID: 10428834
Induction of activator protein 1 (AP-1) in macrophages by human immunodeficiency virus type-1 NEF is a cell-type-specific response that requires both hck and MAPK signaling events.
Biggs TE, Cooke SJ, Barton CH, Harris MP, Saksela K, Mann DA
J Mol Biol. 1999
PubMed ID: 10388555
Role of the ATFa/JNK2 complex in Jun activation.
De Graeve F, Bahr A, Sabapathy KT, Hauss C, Wagner EF, Kedinger C, Chatton B
Oncogene. 1999
PubMed ID: 10376527
The role of HMG I(Y) in the assembly and function of the IFN-beta enhanceosome.
Yie J, Merika M, Munshi N, Chen G, Thanos D
EMBO J. 1999
PubMed ID: 10357819
c-jun Is dispensable for developmental cell death and axogenesis in the retina.
Herzog KH, Chen SC, Morgan JI
J Neurosci. 1999
PubMed ID: 10341238
A two-hit mechanism for vitamin D3-mediated transcriptional repression of the granulocyte-macrophage colony-stimulating factor gene: vitamin D receptor competes for DNA binding with NFAT1 and stabilizes c-Jun.
Towers TL, Staeva TP, Freedman LP
Mol Cell Biol. 1999
PubMed ID: 10330159
Functions of c-Jun in liver and heart development.
Eferl R, Sibilia M, Hilberg F, Fuchsbichler A, Kufferath I, Guertl B, Zenz R, Wagner EF, Zatloukal K
J Cell Biol. 1999
PubMed ID: 10352021
Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain.
Baud V, Liu ZG, Bennett B, Suzuki N, Xia Y, Karin M
Genes Dev. 1999
PubMed ID: 10346818
Molecular cloning and characterization of a novel member of the MAP kinase superfamily.
Miyata Y, Akashi M, Nishida E
Genes Cells. 1999
PubMed ID: 10421840
Smads bind directly to the Jun family of AP-1 transcription factors.
Liberati NT, Datto MB, Frederick JP, Shen X, Wong C, Rougier-Chapman EM, Wang XF
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10220381
SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1.
Rao S, Matsumura A, Yoon J, Simon MC
J Biol Chem. 1999
PubMed ID: 10196196
The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development.
Kuan CY, Yang DD, Samanta Roy DR, Davis RJ, Rakic P, Flavell RA
Neuron. 1999
PubMed ID: 10230788
Exon structure of the nuclear factor I DNA-binding domain from C. elegans to mammals.
Fletcher CF, Jenkins NA, Copeland NG, Chaudhry AZ, Gronostajski RM
Mamm Genome. 1999
PubMed ID: 10087299
Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation.
Behrens A, Sibilia M, Wagner EF
Nat Genet. 1999
PubMed ID: 10080190
Characterization of absence seizure-dependent cyclic AMP responsive element-and activator protein 1 DNA-binding activities in lethargic (lh/lh) mice.
Ishige K, Ito Y, Fukuda H
Neurosci Lett. 1999
PubMed ID: 10076871
Recruitment of the retinoblastoma protein to c-Jun enhances transcription activity mediated through the AP-1 binding site.
Nishitani J, Nishinaka T, Cheng CH, Rong W, Yokoyama KK, Chiu R
J Biol Chem. 1999
PubMed ID: 10026157
JunB is essential for mammalian placentation.
Schorpp-Kistner M, Wang ZQ, Angel P, Wagner EF
EMBO J. 1999
PubMed ID: 10022836
Activation of neurotrophin-3 receptor TrkC induces apoptosis in medulloblastomas.
Kim JY, Sutton ME, Lu DJ, Cho TA, Goumnerova LC, Goritchenko L, Kaufman JR, Lam KK, Billet AL, Tarbell NJ, Wu J, Allen JC, Stiles CD, Segal RA, Pomeroy SL
Cancer Res. 1999
PubMed ID: 9973222
Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4.
Nishina H, Vaz C, Billia P, Nghiem M, Sasaki T, De la Pompa JL, Furlonger K, Paige C, Hui C, Fischer KD, Kishimoto H, Iwatsubo T, Katada T, Woodgett JR, Penninger JM
Development. 1999
PubMed ID: 9876179
Nuclear translocation of Fos is stimulated by interaction with Jun through the leucine zipper.
Chida K, Nagamori S, Kuroki T
Cell Mol Life Sci. 1999
PubMed ID: 10188588
c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms.
Wisdom R, Johnson RS, Moore C
EMBO J. 1999
PubMed ID: 9878062
Targeting of the visna virus tat protein to AP-1 sites: interactions with the bZIP domains of fos and jun in vitro and in vivo.
Morse BA, Carruth LM, Clements JE
J Virol. 1999
PubMed ID: 9847304
Molecular basis of pituitary oncogenesis.
Tada M, Kobayashi H, Moriuchi T
J Neurooncol. 1999
PubMed ID: 10728913
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
HIV-1 gp120 induces the activation of both c-fos and c-jun immediate-early genes in HEL megakaryocytic cells.
Gibellini D, Re MC, Bassini A, Guidotti L, Catani L, La Placa M, Zauli G
Br J Haematol. 1999
PubMed ID: 10027715
Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes.
Venugopal R, Jaiswal AK
Oncogene. 1998
PubMed ID: 9872330
Protein phosphatase X interacts with c-Rel and stimulates c-Rel/nuclear factor kappaB activity.
Hu MC, Tang-Oxley Q, Qiu WR, Wang YP, Mihindukulasuriya KA, Afshar R, Tan TH
J Biol Chem. 1998
PubMed ID: 9837938
Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins.
Herdegen T, Leah JD
Brain Res Brain Res Rev. 1998
PubMed ID: 9858769
beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein.
Premont RT, Claing A, Vitale N, Freeman JL, Pitcher JA, Patton WA, Moss J, Vaughan M, Lefkowitz RJ
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9826657
CBP alleviates the intramolecular inhibition of ATF-2 function.
Sano Y, Tokitou F, Dai P, Maekawa T, Yamamoto T, Ishii S
J Biol Chem. 1998
PubMed ID: 9786917
ASK1 is essential for JNK/SAPK activation by TRAF2.
Nishitoh H, Saitoh M, Mochida Y, Takeda K, Nakano H, Rothe M, Miyazono K, Ichijo H
Mol Cell. 1998
PubMed ID: 9774977
Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription.
Zhang Y, Feng XH, Derynck R
Nature. 1998
PubMed ID: 9732876
Casein kinase II interacts with the bZIP domains of several transcription factors.
Yamaguchi Y, Wada T, Suzuki F, Takagi T, Hasegawa J, Handa H
Nucleic Acids Res. 1998
PubMed ID: 9685505
Possible role of c-Jun in transcription of the mouse renin gene.
Tamura K, Umemura S, Nyui N, Yabana M, Toya Y, Fukamizu A, Murakami K, Ishii M
Kidney Int. 1998
PubMed ID: 9690204
HIV-Tat protein activates c-Jun N-terminal kinase and activator protein-1.
Kumar A, Manna SK, Dhawan S, Aggarwal BB
J Immunol. 1998
PubMed ID: 9670954
Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury.
Herdegen T, Claret FX, Kallunki T, Martin-Villalba A, Winter C, Hunter T, Karin M
J Neurosci. 1998
PubMed ID: 9651196
Steroid receptor coactivator-1 coactivates activating protein-1-mediated transactivations through interaction with the c-Jun and c-Fos subunits.
Lee SK, Kim HJ, Na SY, Kim TS, Choi HS, Im SY, Lee JW
J Biol Chem. 1998
PubMed ID: 9642216
Human immunodeficiency virus tat modulates the Flk-1/KDR receptor, mitogen-activated protein kinases, and components of focal adhesion in Kaposi's sarcoma cells.
Ganju RK, Munshi N, Nair BC, Liu ZY, Gill P, Groopman JE
J Virol. 1998
PubMed ID: 9621077
Erg proteins, transcription factors of the Ets family, form homo, heterodimers and ternary complexes via two distinct domains.
Carrère S, Verger A, Flourens A, Stehelin D, Duterque-Coquillaud M
Oncogene. 1998
PubMed ID: 9681824
PRAK, a novel protein kinase regulated by the p38 MAP kinase.
New L, Jiang Y, Zhao M, Liu K, Zhu W, Flood LJ, Kato Y, Parry GC, Han J
EMBO J. 1998
PubMed ID: 9628874
Modulation of Fos-mediated AP-1 transcription by the promyelocytic leukemia protein.
Vallian S, Gäken JA, Gingold EB, Kouzarides T, Chang KS, Farzaneh F
Oncogene. 1998
PubMed ID: 9671405
Tumor necrosis factor alpha gene regulation: enhancement of C/EBPbeta-induced activation by c-Jun.
Zagariya A, Mungre S, Lovis R, Birrer M, Ness S, Thimmapaya B, Pope R
Mol Cell Biol. 1998
PubMed ID: 9566900
Murine cerberus homologue Cer1 maps to chromosome 4.
Stanley E, Gilbert DG, Jenkins NA, Copeland NG, Harvey RP
Genomics. 1998
PubMed ID: 9598328
Rb binds c-Jun and activates transcription.
Nead MA, Baglia LA, Antinore MJ, Ludlow JW, McCance DJ
EMBO J. 1998
PubMed ID: 9545246
Mapping of the CYP2J cytochrome P450 genes to human chromosome 1 and mouse chromosome 4.
Ma J, Ramachandran S, Fiedorek FT, Zeldin DC
Genomics. 1998
PubMed ID: 9570962
Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA.
Chen L, Glover JN, Hogan PG, Rao A, Harrison SC
Nature. 1998
PubMed ID: 9510247
Bone-specific expression of the alpha chain of the nascent polypeptide-associated complex, a coactivator potentiating c-Jun-mediated transcription.
Moreau A, Yotov WV, Glorieux FH, St-Arnaud R
Mol Cell Biol. 1998
PubMed ID: 9488446
The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes.
Auer KL, Contessa J, Brenz-Verca S, Pirola L, Rusconi S, Cooper G, Abo A, Wymann MP, Davis RJ, Birrer M, Dent P
Mol Biol Cell. 1998
PubMed ID: 9487126
Gene organization and chromosome location of the neural-specific RNA binding protein Elavl4.
Inman MV, Levy S, Mock BA, Owens GC
Gene. 1998
PubMed ID: 9524251
Role of activating protein-1 in the regulation of the vascular cell adhesion molecule-1 gene expression by tumor necrosis factor-alpha.
Ahmad M, Theofanidis P, Medford RM
J Biol Chem. 1998
PubMed ID: 9468519
Molecular cloning reveals that the p160 Myb-binding protein is a novel, predominantly nucleolar protein which may play a role in transactivation by Myb.
Tavner FJ, Simpson R, Tashiro S, Favier D, Jenkins NA, Gilbert DJ, Copeland NG, Macmillan EM, Lutwyche J, Keough RA, Ishii S, Gonda TJ
Mol Cell Biol. 1998
PubMed ID: 9447996
An ATF/CRE element mediates both EBNA2-dependent and EBNA2-independent activation of the Epstein-Barr virus LMP1 gene promoter.
Sjöblom A, Yang W, Palmqvist L, Jansson A, Rymo L
J Virol. 1998
PubMed ID: 9445037
Platelet-activating factor induction of activator protein-1 signaling in bronchial epithelial cells.
LeVan TD, Bloom JW, Adams DG, Hensel JL, Halonen M
Mol Pharmacol. 1998
PubMed ID: 9443941
Activation of c-Jun N-terminal kinase during ischemia and reperfusion in mouse liver.
Onishi I, Tani T, Hashimoto T, Shimizu K, Yagi M, Yamamoto K, Yoshioka K
FEBS Lett. 1997
PubMed ID: 9459310
Activation of stress-activated protein kinases/c-Jun N-terminal protein kinases (SAPKs/JNKs) by a novel mitogen-activated protein kinase kinase.
Yao Z, Diener K, Wang XS, Zukowski M, Matsumoto G, Zhou G, Mo R, Sasaki T, Nishina H, Hui CC, Tan TH, Woodgett JP, Penninger JM
J Biol Chem. 1997
PubMed ID: 9405446
c-Jun NH2-terminal kinases target the ubiquitination of their associated transcription factors.
Fuchs SY, Xie B, Adler V, Fried VA, Davis RJ, Ronai Z
J Biol Chem. 1997
PubMed ID: 9405416
Fluid shear stress activation of focal adhesion kinase. Linking to mitogen-activated protein kinases.
Li S, Kim M, Hu YL, Jalali S, Schlaepfer DD, Hunter T, Chien S, Shyy JY
J Biol Chem. 1997
PubMed ID: 9374537
Dynamic regulation of c-Jun N-terminal kinase activity in mouse brain by environmental stimuli.
Xu X, Raber J, Yang D, Su B, Mucke L
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9356505
Basal expression, subcellular distribution, and up-regulation of the proto-oncogene c-JUN in the rat dentate gyrus after unilateral entorhinal cortex lesion.
Haas CA, Deller T, Frotscher M
Neuroscience. 1997
PubMed ID: 9300399
A regulatory element within a coding exon modulates keratin 18 gene expression in transgenic mice.
Neznanov N, Umezawa A, Oshima RG
J Biol Chem. 1997
PubMed ID: 9346889
The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner.
Basuyaux JP, Ferreira E, Stéhelin D, Butticè G
J Biol Chem. 1997
PubMed ID: 9334186
The uroguanylin gene (Guca1b) is linked to guanylin (Guca2) on mouse chromosome 4.
Whitaker TL, Steinbrecher KA, Copeland NG, Gilbert DJ, Jenkins NA, Cohen MB
Genomics. 1997
PubMed ID: 9344659
Modulation of cellular AP-1 DNA binding activity by heat shock proteins.
Carter DA
FEBS Lett. 1997
PubMed ID: 9369238
p38-2, a novel mitogen-activated protein kinase with distinct properties.
Stein B, Yang MX, Young DB, Janknecht R, Hunter T, Murray BW, Barbosa MS
J Biol Chem. 1997
PubMed ID: 9235954
Tat protein induces self-perpetuating permissivity for productive HIV-1 infection.
Li CJ, Ueda Y, Shi B, Borodyansky L, Huang L, Li YZ, Pardee AB
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9223324
Androgenic induction of prostate-specific antigen gene is repressed by protein-protein interaction between the androgen receptor and AP-1/c-Jun in the human prostate cancer cell line LNCaP.
Sato N, Sadar MD, Bruchovsky N, Saatcioglu F, Rennie PS, Sato S, Lange PH, Gleave ME
J Biol Chem. 1997
PubMed ID: 9211894
Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase.
Tournier C, Whitmarsh AJ, Cavanagh J, Barrett T, Davis RJ
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9207092
The c-Jun-induced transformation process involves complex regulation of tenascin-C expression.
Mettouchi A, Cabon F, Montreau N, Dejong V, Vernier P, Gherzi R, Mercier G, Binétruy B
Mol Cell Biol. 1997
PubMed ID: 9154819
Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions.
Aronheim A, Zandi E, Hennemann H, Elledge SJ, Karin M
Mol Cell Biol. 1997
PubMed ID: 9154808
Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity.
Pognonec P, Boulukos KE, Aperlo C, Fujimoto M, Ariga H, Nomoto A, Kato H
Oncogene. 1997
PubMed ID: 9160889
The c-Jun transcription factor--bipotential mediator of neuronal death, survival and regeneration.
Herdegen T, Skene P, Bähr M
Trends Neurosci. 1997
PubMed ID: 9141200
Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for Rac-dependent membrane ruffling and C-Jun NH2-terminal kinase activation.
Michiels F, Stam JC, Hordijk PL, van der Kammen RA, Ruuls-Van Stalle L, Feltkamp CA, Collard JG
J Cell Biol. 1997
PubMed ID: 9128250
MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates.
Fukunaga R, Hunter T
EMBO J. 1997
PubMed ID: 9155018
Activation of JNK signaling pathway by erythropoietin, thrombopoietin, and interleukin-3.
Nagata Y, Nishida E, Todokoro K
Blood. 1997
PubMed ID: 9108383
Bruton's tyrosine kinase regulates apoptosis and JNK/SAPK kinase activity.
Kawakami Y, Miura T, Bissonnette R, Hata D, Khan WN, Kitamura T, Maeda-Yamamoto M, Hartman SE, Yao L, Alt FW, Kawakami T
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9108083
Developmental expression of morphoregulatory genes in the mouse embryo: an analytical approach using a novel technology.
Craig JC, Eberwine JH, Calvin JA, Wlodarczyk B, Bennett GD, Finnell RH
Biochem Mol Med. 1997
PubMed ID: 9169087
An RGD containing peptide from HIV-1 Tat-(65-80) modulates protooncogene expression in human bronchoalveolar carcinoma cell line, A549.
el-Solh A, Kumar NM, Nair MP, Schwartz SA, Lwebuga-Mukasa JS
Immunol Invest. 1997
PubMed ID: 9129988
c-Jun inhibits NF-E2 transcriptional activity in association with p18/maf in Friend erythroleukemia cells.
Francastel C, Augery-Bourget Y, Prenant M, Walters M, Martin DI, Robert-Lézénès J
Oncogene. 1997
PubMed ID: 9047395
Activation of the Sap-1a transcription factor by the c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase.
Janknecht R, Hunter T
J Biol Chem. 1997
PubMed ID: 9020136
Common quantitative trait loci for alcohol-related behaviors and central nervous system neurotensin measures: hypnotic and hypothermic effects.
Erwin VG, Markel PD, Johnson TE, Gehle VM, Jones BC
J Pharmacol Exp Ther. 1997
PubMed ID: 9023306
Regulatory mechanisms involved in activator-protein-1 (AP-1)-mediated activation of glutathione-S-transferase gene expression by chemical agents.
Ainbinder E, Bergelson S, Pinkus R, Daniel V
Eur J Biochem. 1997
PubMed ID: 9030721
A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells.
Garrett-Sinha LA, Eberspaecher H, Seldin MF, de Crombrugghe B
J Biol Chem. 1996
PubMed ID: 8940147
Valproic acid-induced changes in gene expression during neurulation in a mouse model.
Wlodarczyk BC, Craig JC, Bennett GD, Calvin JA, Finnell RH
Teratology. 1996
PubMed ID: 9098922
Jun: transcription factor and oncoprotein.
Rahmsdorf HJ
J Mol Med. 1996
PubMed ID: 8974016
c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions.
Kallunki T, Deng T, Hibi M, Karin M
Cell. 1996
PubMed ID: 8945519
c-Jun can mediate androgen receptor-induced transactivation.
Bubulya A, Wise SC, Shen XQ, Burmeister LA, Shemshedini L
J Biol Chem. 1996
PubMed ID: 8798722
A new group of conserved coactivators that increase the specificity of AP-1 transcription factors.
Claret FX, Hibi M, Dhut S, Toda T, Karin M
Nature. 1996
PubMed ID: 8837781
Genesis, a winged helix transcriptional repressor with expression restricted to embryonic stem cells.
Sutton J, Costa R, Klug M, Field L, Xu D, Largaespada DA, Fletcher CF, Jenkins NA, Copeland NG, Klemsz M, Hromas R
J Biol Chem. 1996
PubMed ID: 8798505
Genetic characterization of a mammalian protein-protein interaction domain by using a yeast reverse two-hybrid system.
Vidal M, Braun P, Chen E, Boeke JD, Harlow E
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8816798
Reverse two-hybrid and one-hybrid systems to detect dissociation of protein-protein and DNA-protein interactions.
Vidal M, Brachmann RK, Fattaey A, Harlow E, Boeke JD
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8816797
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
AP1 enhances polyomavirus DNA replication by promoting T-antigen-mediated unwinding of DNA.
Guo W, Tang WJ, Bu X, Bermudez V, Martin M, Folk WR
J Virol. 1996
PubMed ID: 8763994
Cross-talk between different enhancer elements during mitogenic induction of the human stromelysin-1 gene.
Kirstein M, Sanz L, Quiñones S, Moscat J, Diaz-Meco MT, Saus J
J Biol Chem. 1996
PubMed ID: 8663478
The c-Jun delta-domain inhibits neuroendocrine promoter activity in a DNA sequence- and pituitary-specific manner.
Farrow KN, Manning N, Schaufele F, Gutierrez-Hartmann A
J Biol Chem. 1996
PubMed ID: 8663380
High resolution NMR solution structure of the leucine zipper domain of the c-Jun homodimer.
Junius FK, O'Donoghue SI, Nilges M, Weiss AS, King GF
J Biol Chem. 1996
PubMed ID: 8662824
Selective interaction of JNK protein kinase isoforms with transcription factors.
Gupta S, Barrett T, Whitmarsh AJ, Cavanagh J, Sluss HK, Dérijard B, Davis RJ
EMBO J. 1996
PubMed ID: 8654373
Molecular cloning of c-jun and c-fos cDNAs from porcine anterior pituitary and their involvement in gonadotropin-releasing hormone stimulation.
Chung HO, Kato T, Kato Y
Mol Cell Endocrinol. 1996
PubMed ID: 8793856
Binding of HIV-1 virions or gp120-anti-gp120 immune complexes to HIV-1-infected quiescent peripheral blood mononuclear cells reveals latent infection.
Briant L, Coudronnière N, Robert-Hebmann V, Benkirane M, Devaux C
J Immunol. 1996
PubMed ID: 8621941
Fos-Jun dimerization promotes interaction of the basic region with TFIIE-34 and TFIIF.
Martin ML, Lieberman PM, Curran T
Mol Cell Biol. 1996
PubMed ID: 8628277
The human papillomavirus type 16 E7 gene product interacts with and trans-activates the AP1 family of transcription factors.
Antinore MJ, Birrer MJ, Patel D, Nader L, McCance DJ
EMBO J. 1996
PubMed ID: 8617242
Interaction between c-Rel and the mitogen-activated protein kinase kinase kinase 1 signaling cascade in mediating kappaB enhancer activation.
Meyer CF, Wang X, Chang C, Templeton D, Tan TH
J Biol Chem. 1996
PubMed ID: 8621542
Interaction of the Ubc9 human homologue with c-Jun and with the glucocorticoid receptor.
Göttlicher M, Heck S, Doucas V, Wade E, Kullmann M, Cato AC, Evans RM, Herrlich P
Steroids. 1996
PubMed ID: 8733011
Altered AP-1/ATF complexes in adenovirus-E1-transformed cells due to EIA-dependent induction of ATF3.
Hagmeyer BM, Duyndam MC, Angel P, de Groot RP, Verlaan M, Elfferich P, van der Eb A, Zantema A
Oncogene. 1996
PubMed ID: 8649793
Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10.
Chen BP, Wolfgang CD, Hai T
Mol Cell Biol. 1996
PubMed ID: 8622660
Activation of the JNK pathway by distantly related protein kinases, MEKK and MUK.
Hirai S, Izawa M, Osada S, Spyrou G, Ohno S
Oncogene. 1996
PubMed ID: 8637721
Synergistic transcriptional activation of the tissue inhibitor of metalloproteinases-1 promoter via functional interaction of AP-1 and Ets-1 transcription factors.
Logan SK, Garabedian MJ, Campbell CE, Werb Z
J Biol Chem. 1996
PubMed ID: 8557686
Differential expression of fos and jun family members during murine postnatal intestinal development.
Blais S, Boudreau F, Thorneloe K, Asselin C
Biol Neonate. 1996
PubMed ID: 8790912
Arsenic-induced alterations in embryonic transcription factor gene expression: implications for abnormal neural development.
Wlodraczyk B, Bennett GD, Calvin JA, Craig JC, Finnell RH
Dev Genet. 1996
PubMed ID: 8754282
Programmed cell death in the absence of c-Fos and c-Jun.
Roffler-Tarlov S, Brown JJ, Tarlov E, Stolarov J, Chapman DL, Alexiou M, Papaioannou VE
Development. 1996
PubMed ID: 8565820
B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family.
Dorsey MJ, Tae HJ, Sollenberger KG, Mascarenhas NT, Johansen LM, Taparowsky EJ
Oncogene. 1995
PubMed ID: 8570175
Neither ERK nor JNK/SAPK MAP kinase subtypes are essential for histone H3/HMG-14 phosphorylation or c-fos and c-jun induction.
Cano E, Hazzalin CA, Kardalinou E, Buckle RS, Mahadevan LC
J Cell Sci. 1995
PubMed ID: 8586671
Arachidonic acid induces c-jun gene expression in stromal cells stimulated by interleukin-1 and tumor necrosis factor-alpha: evidence for a tyrosine-kinase-dependent process.
Rizzo MT, Boswell HS, Mangoni L, Carlo-Stella C, Rizzoli V
Blood. 1995
PubMed ID: 7579389
The human cytomegalovirus IE2 86-kilodalton protein interacts with an early gene promoter via site-specific DNA binding and protein-protein associations.
Scully AL, Sommer MH, Schwartz R, Spector DH
J Virol. 1995
PubMed ID: 7666555
Mapping of quantitative trait loci for blood pressure and cardiac mass in the rat by genome scanning of recombinant inbred strains.
Pravenec M, Gauguier D, Schott JJ, Buard J, Kren V, Bila V, Szpirer C, Szpirer J, Wang JM, Huang H
J Clin Invest. 1995
PubMed ID: 7560090
Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3.
Schaefer TS, Sanders LK, Nathans D
Proc Natl Acad Sci U S A. 1995
PubMed ID: 7568080
DNA fragmentation and activation of c-Jun in the cerebellum of mutant mice (weaver, Purkinje cell degeneration).
Gillardon F, Bäurle J, Grüsser-Cornehls U, Zimmermann M
Neuroreport. 1995
PubMed ID: 8541477
HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cells.
Chirmule N, Goonewardena H, Pahwa S, Pasieka R, Kalyanaraman VS, Pahwa S
J Biol Chem. 1995
PubMed ID: 7642615
RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation.
Zhao Y, Bjørbaek C, Weremowicz S, Morton CC, Moller DE
Mol Cell Biol. 1995
PubMed ID: 7623830
Synergistic activation of neurotensin/neuromedin N gene expression by c-Jun and glucocorticoids: novel effects of Fos family proteins.
Harrison RJ, McNeil GP, Dobner PR
Mol Endocrinol. 1995
PubMed ID: 7476995
Developmental expression of APEX nuclease, a multifunctional DNA repair enzyme, in mouse brains.
Ono Y, Watanabe M, Inoue Y, Ohmoto T, Akiyama K, Tsutsui K, Seki S
Brain Res Dev Brain Res. 1995
PubMed ID: 7656403
Activated Ha-Ras but not TPA induces transcription through binding sites for activating transcription factor 3/Jun and a novel nuclear factor.
Nilsson M, Toftgård R, Bohm S
J Biol Chem. 1995
PubMed ID: 7744871
Repression of the c-Jun trans-activation function by the adenovirus type 12 E1A 52R protein correlates with the inhibition of phosphorylation of the c-Jun activation domain.
Brockmann D, Bury C, Kröner G, Kirch HC, Esche H
J Biol Chem. 1995
PubMed ID: 7738014
A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death.
Ham J, Babij C, Whitfield J, Pfarr CM, Lallemand D, Yaniv M, Rubin LL
Neuron. 1995
PubMed ID: 7748560
The leucine zipper of c-Jun binds to ribosomal protein L18a: a role in Jun protein regulation?
Gramatikoff K, Schaffner W, Georgiev O
Biol Chem Hoppe Seyler. 1995
PubMed ID: 7662174
The protooncogene c-jun contains an unusual estrogen-inducible enhancer within the coding sequence.
Hyder SM, Nawaz Z, Chiappetta C, Yokoyama K, Stancel GM
J Biol Chem. 1995
PubMed ID: 7721748
Tissue-specific expression of the fos-related transcription factor fra-2 during mouse development.
Carrasco D, Bravo R
Oncogene. 1995
PubMed ID: 7700631
c-jun inhibits insulin control element-mediated transcription by affecting the transactivation potential of the E2A gene products.
Robinson GL, Henderson E, Massari ME, Murre C, Stein R
Mol Cell Biol. 1995
PubMed ID: 7862133
In vitro association between the Jun protein family and the general transcription factors, TBP and TFIIB.
Franklin CC, McCulloch AV, Kraft AS
Biochem J. 1995
PubMed ID: 7848298
Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors.
Scheinman RI, Gualberto A, Jewell CM, Cidlowski JA, Baldwin AS
Mol Cell Biol. 1995
PubMed ID: 7823959
Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA.
Glover JN, Harrison SC
Nature. 1995
PubMed ID: 7816143
Expression and characterization of mouse cFos protein using the baculovirus expression system: ability to form functional AP-1 complex with coexpressed cJun protein.
Corvello CM, Metz R, Bravo R, Armelin MC
Cell Mol Biol Res. 1995
PubMed ID: 8777432
C-JUN/AP-1 as possible mediators of tumor necrosis factor-alpha-induced apoptotic response in mouse JB6 tumor cells.
Singh N, Sun Y, Nakamura K, Smith MR, Colburn NH
Oncol Res. 1995
PubMed ID: 8747598
Genetic map of rat chromosome 5 including the fatty (fa) locus.
Truett GE, Jacob HJ, Miller J, Drouin G, Bahary N, Smoller JW, Lander ES, Leibel RL
Mamm Genome. 1995
PubMed ID: 7719022
Identification of hepatocarcinogen-resistance genes in DBA/2 mice.
Lee GH, Bennett LM, Carabeo RA, Drinkwater NR
Genetics. 1995
PubMed ID: 7705639
Altered gene expression in murine branchial arches following in utero exposure to retinoic acid.
Taylor LE, Bennett GD, Finnell RH
J Craniofac Genet Dev Biol. 1995
PubMed ID: 7601910
Differential regulation of proto-oncogenes c-jun and c-fos in T lymphocytes activated through CD28.
Chatta GS, Spies AG, Chang S, Mize GJ, Linsley PS, Ledbetter JA, Morris DR
J Immunol. 1994
PubMed ID: 7989745
Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis.
Estus S, Zaks WJ, Freeman RS, Gruda M, Bravo R, Johnson EM
J Cell Biol. 1994
PubMed ID: 7798322
Interaction of HIV gp120 and anti-CD4 antibodies with the CD4 molecule on human CD4+ T cells inhibits the binding activity of NF-AT, NF-kappa B and AP-1, three nuclear factors regulating interleukin-2 gene enhancer activity.
Jabado N, Le Deist F, Fisher A, Hivroz C
Eur J Immunol. 1994
PubMed ID: 7957556
Effect of curcumin on 12-O-tetradecanoylphorbol-13-acetate- and ultraviolet B light-induced expression of c-Jun and c-Fos in JB6 cells and in mouse epidermis.
Lu YP, Chang RL, Lou YR, Huang MT, Newmark HL, Reuhl KR, Conney AH
Carcinogenesis. 1994
PubMed ID: 7955078
Evi-1 raises AP-1 activity and stimulates c-fos promoter transactivation with dependence on the second zinc finger domain.
Tanaka T, Nishida J, Mitani K, Ogawa S, Yazaki Y, Hirai H
J Biol Chem. 1994
PubMed ID: 7929053
Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain.
Treier M, Staszewski LM, Bohmann D
Cell. 1994
PubMed ID: 8087846
c-Jun expression in single cells and preneoplastic foci induced by diethylnitrosamine in B6C3F1 mice: comparison with the expression of pi-class glutathione S-transferase.
Nakano H, Hatayama I, Satoh K, Suzuki S, Sato K, Tsuchida S
Carcinogenesis. 1994
PubMed ID: 7923577
Preliminary evidence of phenytoin-induced alterations in embryonic gene expression in a mouse model.
Musselman AC, Bennett GD, Greer KA, Eberwine JH, Finnell RH
Reprod Toxicol. 1994
PubMed ID: 7841657
Mapping of PCR-based markers for mouse chromosome 4 on a backcross penetrant for the misty (m) mutation.
Fiedorek FT, Kay ES
Mamm Genome. 1994
PubMed ID: 7949731
Sequence-specific impairment of learning by c-jun antisense oligonucleotides.
Tischmeyer W, Grimm R, Schicknick H, Brysch W, Schlingensiepen KH
Neuroreport. 1994
PubMed ID: 7948848
Phorbol esters support the proliferation of a hematopoietic cell line by upregulating c-jun expression.
Mayo MW, Steelman LS, McCubrey JA
Oncogene. 1994
PubMed ID: 8208545
Antisense c-jun overcomes a differentiation block in a murine erythroleukemia cell line.
Francastel C, Groisman R, Pfarr CM, Robert-Lézénès J
Oncogene. 1994
PubMed ID: 8208542
Interaction of nuclear proteins with an AP-1/CRE-like promoter sequence in the human TNF-alpha gene.
Newell CL, Deisseroth AB, Lopez-Berestein G
J Leukoc Biol. 1994
PubMed ID: 8027667
Differentiation of WEHI-3B D+ myelomonocytic leukemia cells induced by ectopic expression of the protooncogene c-jun.
Li J, King I, Sartorelli AC
Cell Growth Differ. 1994
PubMed ID: 7947389
Changes in cell cycle-associated gene expression in a model of impaired liver regeneration.
Albrecht JH, Hoffman JS, Kren BT, Steer CJ
FEBS Lett. 1994
PubMed ID: 8033995
Adipocyte differentiation selectively represses the serum inducibility of c-jun and junB by reversible transcription-dependent mechanisms.
Wang H, Scott RE
Proc Natl Acad Sci U S A. 1994
PubMed ID: 8197114
Mouse thioredoxin gene maps on chromosome 4, whereas its pseudogene maps on chromosome 1.
Taketo M, Matsui M, Rochelle JM, Yodoi J, Seldin MF
Genomics. 1994
PubMed ID: 8088797
Phenotypic alterations in fos-transgenic mice correlate with changes in Fos/Jun-dependent collagenase type I expression. Regulation of mouse metalloproteinases by carcinogens, tumor promoters, cAMP, and Fos oncoprotein.
Gack S, Vallon R, Schaper J, Rüther U, Angel P
J Biol Chem. 1994
PubMed ID: 8144618
Cloning of the human glycine transporter type 1: molecular and pharmacological characterization of novel isoform variants and chromosomal localization of the gene in the human and mouse genomes.
Kim KM, Kingsmore SF, Han H, Yang-Feng TL, Godinot N, Seldin MF, Caron MG, Giros B
Mol Pharmacol. 1994
PubMed ID: 8183239
Differential induction of the two early genes c-jun and c-fos in weakly and strongly metastatic murine lymphoma cell lines.
Rossi D, Fumagalli S, Volpi L, Larizza L
Int J Cancer. 1994
PubMed ID: 8150544
Estrogen differentially affects c-jun expression in uterine tissue compartments.
Nephew KP, Tang M, Khan SA
Endocrinology. 1994
PubMed ID: 8137749
A genetic linkage map of rat chromosome 5 reveals extensive linkage conservation with mouse chromosome 4.
Kobayashi E, Tachibana M, Ikadai H, Kunieda T
Mamm Genome. 1994
PubMed ID: 8012112
Generation of normal T and B lymphocytes by c-jun deficient embryonic stem cells.
Chen J, Stewart V, Spyrou G, Hilberg F, Wagner EF, Alt FW
Immunity. 1994
PubMed ID: 7889400
JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain.
Dérijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T, Karin M, Davis RJ
Cell. 1994
PubMed ID: 8137421
Genes that control the formation of the liver.
Zaret K
Hepatology. 1994
PubMed ID: 8119710
Maf and Nrl can bind to AP-1 sites and form heterodimers with Fos and Jun.
Kerppola TK, Curran T
Oncogene. 1994
PubMed ID: 8108109
v-jun oncogene suppresses both phorbol ester-induced cell invasion and stromelysin gene expression in a mouse papilloma cell line.
Tsang TC, Chu YW, Powell MB, Kittelson J, Meade-Tollin L, Hendrix MJ, Bowden GT
Cancer Res. 1994
PubMed ID: 8313375
Serum-independent phosphorylation of c-Jun and alterations in AP-1 components by transformation with various oncogenes.
Kamada S, Toyoshima K, Akiyama T
J Biol Chem. 1994
PubMed ID: 8308027
c-fos and jun gene expression in murine precursor B lymphocytes developed in the interleukin-7-dependent bone marrow cell culture.
Fujita K, Imoto S, Phuchareon J, Tokuhisa T
Immunobiology. 1994
PubMed ID: 8082881
Detection of proteins that bind to the leucine zipper motif of c-Myb.
Favier D, Gonda TJ
Oncogene. 1994
PubMed ID: 8302594
Stable expression of a c-JUN deletion mutant in two malignant mouse epidermal cell lines blocks tumor formation in nude mice.
Domann FE, Levy JP, Birrer MJ, Bowden GT
Cell Growth Differ. 1994
PubMed ID: 8123597
Presence and possible role of c-ras and nuclear (c-fos and c-jun) proto-oncogene products in preimplantation embryonic development in mice.
Ahmad K, Naz RK
Mol Reprod Dev. 1993
PubMed ID: 8286110
Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.
Hibi M, Lin A, Smeal T, Minden A, Karin M
Genes Dev. 1993
PubMed ID: 8224842
Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system.
Sato TN, Qin Y, Kozak CA, Audus KL
Proc Natl Acad Sci U S A. 1993
PubMed ID: 8415706
Characterization of the murine Mpl proto-oncogene, a member of the hematopoietic cytokine receptor family: molecular cloning, chromosomal location and evidence for a function in cell growth.
Vigon I, Florindo C, Fichelson S, Guenet JL, Mattei MG, Souyri M, Cosman D, Gisselbrecht S
Oncogene. 1993
PubMed ID: 8397366
In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor.
Jeang KT, Chun R, Lin NH, Gatignol A, Glabe CG, Fan H
J Virol. 1993
PubMed ID: 7690421
The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun.
Jain J, McCaffrey PG, Miner Z, Kerppola TK, Lambert JN, Verdine GL, Curran T, Rao A
Nature. 1993
PubMed ID: 8397339
c-jun is essential for normal mouse development and hepatogenesis.
Hilberg F, Aguzzi A, Howells N, Wagner EF
Nature. 1993
PubMed ID: 8371760
Species-specific induction of cytochrome P-450 4A RNAs: PCR cloning of partial guinea-pig, human and mouse CYP4A cDNAs.
Bell DR, Plant NJ, Rider CG, Na L, Brown S, Ateitalla I, Acharya SK, Davies MH, Elias E, Jenkins NA
Biochem J. 1993
PubMed ID: 8363569
MHC class I gene expression is negatively regulated by the proto-oncogene, c-jun.
Howcroft TK, Richardson JC, Singer DS
EMBO J. 1993
PubMed ID: 8344255
Transforming growth factor beta 1-induced delay of cell cycle progression and its association with growth-related gene expression in mouse fibroblasts.
Kim TA, Cutry AF, Kinniburgh AJ, Wenner CE
Cancer Lett. 1993
PubMed ID: 8364887
Changes in protooncogene expression correlated with general and sex-specific differentiation in murine primordial germ cells.
Coucouvanis EC, Jones PP
Mech Dev. 1993
PubMed ID: 8369223
A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture.
Johnson RS, van Lingen B, Papaioannou VE, Spiegelman BM
Genes Dev. 1993
PubMed ID: 8330736
HIV-1 Nef protein inhibits the recruitment of AP-1 DNA-binding activity in human T-cells.
Niederman TM, Hastings WR, Luria S, Bandres JC, Ratner L
Virology. 1993
PubMed ID: 8480425
Memory processing and apamin induce immediate early gene expression in mouse brain.
Heurteaux C, Messier C, Destrade C, Lazdunski M
Brain Res Mol Brain Res. 1993
PubMed ID: 8479285
Microdissection and microcloning of mid-chromosome 4: genetic mapping of 41 microdissection clones.
Bahary N, McGraw DE, Shilling R, Friedman JM
Genomics. 1993
PubMed ID: 8098006
Expression of c-jun/AP-1 during myogenic differentiation in mouse C2C12 myoblasts.
Thinakaran G, Ojala J, Bag J
FEBS Lett. 1993
PubMed ID: 8458421
c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif.
Bannister AJ, Gottlieb TM, Kouzarides T, Jackson SP
Nucleic Acids Res. 1993
PubMed ID: 8464713
Changes in Hox1.6, c-jun, and Oct-3 gene expressions are associated with teratocarcinoma F9 cell differentiation in three different ways of induction.
Iwai SA, Kosaka M, Nishina Y, Sumi T, Sakuda M, Nishimune Y
Exp Cell Res. 1993
PubMed ID: 8453995
Modification of DNA topoisomerase II activity via direct interactions with the cyclic adenosine-3',5'-monophosphate response element-binding protein and related transcription factors.
Kroll DJ, Sullivan DM, Gutierrez-Hartmann A, Hoeffler JP
Mol Endocrinol. 1993
PubMed ID: 8387155
Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1.
Nomura N, Zu YL, Maekawa T, Tabata S, Akiyama T, Ishii S
J Biol Chem. 1993
PubMed ID: 8440710
Detection and modulation in vivo of helix-loop-helix protein-protein interactions.
Finkel T, Duc J, Fearon ER, Dang CV, Tomaselli GF
J Biol Chem. 1993
PubMed ID: 8380166
Transcription factors junB and c-jun are selectively up-regulated and functionally implicated in fibrosarcoma development.
Bossy-Wetzel E, Bravo R, Hanahan D
Genes Dev. 1992
PubMed ID: 1459456
A common intermediary factor (p52/54) recognizing "acidic blob"-type domains is required for transcriptional activation by the Jun proteins.
Oehler T, Angel P
Mol Cell Biol. 1992
PubMed ID: 1448082
Embryonic stem (ES) cells lacking functional c-jun: consequences for growth and differentiation, AP-1 activity and tumorigenicity.
Hilberg F, Wagner EF
Oncogene. 1992
PubMed ID: 1281302
Proto-oncogene c-jun and c-fos messenger RNAs increase in the liver of carnitine-deficient juvenile visceral steatosis (jvs) mice.
Tomomura M, Nakagawa K, Saheki T
FEBS Lett. 1992
PubMed ID: 1383034
Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity.
Lin A, Frost J, Deng T, Smeal T, al-Alawi N, Kikkawa U, Hunter T, Brenner D, Karin M
Cell. 1992
PubMed ID: 1516134
Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun.
Chevray PM, Nathans D
Proc Natl Acad Sci U S A. 1992
PubMed ID: 1631061
Dioxin induces expression of c-fos and c-jun proto-oncogenes and a large increase in transcription factor AP-1.
Puga A, Nebert DW, Carrier F
DNA Cell Biol. 1992
PubMed ID: 1605850
Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4.
Cutting GR, Curristin S, Zoghbi H, O'Hara B, Seldin MF, Uhl GR
Genomics. 1992
PubMed ID: 1315307
Functional antagonism between c-Jun and MyoD proteins: a direct physical association.
Bengal E, Ransone L, Scharfmann R, Dwarki VJ, Tapscott SJ, Weintraub H, Verma IM
Cell. 1992
PubMed ID: 1310896
A set of anonymous DNA clones as markers for mouse gene mapping.
Le Roy H, Simon-Chazottes D, Montagutelli X, Guénet JL
Mamm Genome. 1992
PubMed ID: 1351769
Transcriptional regulation of the c-jun gene by retinoic acid and E1A during differentiation of F9 cells.
Kitabayashi I, Kawakami Z, Chiu R, Ozawa K, Matsuoka T, Toyoshima S, Umesono K, Evans RM, Gachelin G, Yokoyama K
EMBO J. 1992
PubMed ID: 1310930
junD mRNA expression differs from c-jun and junB mRNA expression during male germinal cell differentiation.
Alcivar AA, Hake LE, Kwon YK, Hecht NB
Mol Reprod Dev. 1991
PubMed ID: 1793595
Phosphorylation of c-jun mediated by MAP kinases.
Pulverer BJ, Kyriakis JM, Avruch J, Nikolakaki E, Woodgett JR
Nature. 1991
PubMed ID: 1922387
Pax: a murine multigene family of paired box-containing genes.
Walther C, Guenet JL, Simon D, Deutsch U, Jostes B, Goulding MD, Plachov D, Balling R, Gruss P
Genomics. 1991
PubMed ID: 1685142
Glucose transporter gene expression in early mouse embryos.
Hogan A, Heyner S, Charron MJ, Copeland NG, Gilbert DJ, Jenkins NA, Thorens B, Schultz GA
Development. 1991
PubMed ID: 1765007
Molecular genetic linkage maps of mouse chromosomes 4 and 6.
Bahary N, Zorich G, Pachter JE, Leibel RL, Friedman JM
Genomics. 1991
PubMed ID: 1684952
Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase.
Alvarez E, Northwood IC, Gonzalez FA, Latour DA, Seth A, Abate C, Curran T, Davis RJ
J Biol Chem. 1991
PubMed ID: 1651323
Genetic mapping in the mouse of four loci related to the jun family of transcriptional activators.
Shapiro M, Kozak CA
Somat Cell Mol Genet. 1991
PubMed ID: 1887331
c-rel activates but v-rel suppresses transcription from kappa B sites.
Inoue J, Kerr LD, Ransone LJ, Bengal E, Hunter T, Verma IM
Proc Natl Acad Sci U S A. 1991
PubMed ID: 2023921
Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity.
Hai T, Curran T
Proc Natl Acad Sci U S A. 1991
PubMed ID: 1827203
Molecular mapping of the mouse db mutation.
Bahary N, Leibel RL, Joseph L, Friedman JM
Proc Natl Acad Sci U S A. 1990
PubMed ID: 1978328
Nucleotide sequence of rat c-jun protooncogene.
Kitabayashi I, Saka F, Gachelin G, Yokoyama K
Nucleic Acids Res. 1990
PubMed ID: 2113275
Mouse vimentin: structural relationship to fos, jun, CREB and tpr.
Capetanaki Y, Kuisk I, Rothblum K, Starnes S
Oncogene. 1990
PubMed ID: 2140597
A cDNA for a human cyclic AMP response element-binding protein which is distinct from CREB and expressed preferentially in brain.
Kara CJ, Liou HC, Ivashkiv LB, Glimcher LH
Mol Cell Biol. 1990
PubMed ID: 2320002
Heterodimer formation between CREB and JUN proteins.
Benbrook DM, Jones NC
Oncogene. 1990
PubMed ID: 2138276
Different members of the jun proto-oncogene family exhibit distinct patterns of expression in response to type beta transforming growth factor.
Li L, Hu JS, Olson EN
J Biol Chem. 1990
PubMed ID: 2104845
Chromosomal localization of the three members of the jun proto-oncogene family in mouse and man.
Mattei MG, Simon-Chazottes D, Hirai S, Ryseck RP, Galcheva-Gargova Z, Guénet JL, Mattei JF, Bravo R, Yaniv M
Oncogene. 1990
PubMed ID: 2108401
A molecular genetic linkage map of mouse chromosome 4 including the localization of several proto-oncogenes.
Ceci JD, Siracusa LD, Jenkins NA, Copeland NG
Genomics. 1989
PubMed ID: 2574141
Structure and expression of the rat c-jun messenger RNA: tissue distribution and increase during chemical hepatocarcinogenesis.
Sakai M, Okuda A, Hatayama I, Sato K, Nishi S, Muramatsu M
Cancer Res. 1989
PubMed ID: 2507134
DNA binding activities of three murine Jun proteins: stimulation by Fos.
Nakabeppu Y, Ryder K, Nathans D
Cell. 1988
PubMed ID: 3142691
Structure and chromosomal localization of the functional intronless human JUN protooncogene.
Hattori K, Angel P, Le Beau MM, Karin M
Proc Natl Acad Sci U S A. 1988
PubMed ID: 3194415
Induction of protooncogene c-jun by serum growth factors.
Ryder K, Nathans D
Proc Natl Acad Sci U S A. 1988
PubMed ID: 3186736
Induction of proto-oncogene JUN/AP-1 by serum and TPA.
Lamph WW, Wamsley P, Sassone-Corsi P, Verma IM
Nature. 1988
PubMed ID: 2457172
Transcriptional activation of c-jun during the G0/G1 transition in mouse fibroblasts.
Ryseck RP, Hirai SI, Yaniv M, Bravo R
Nature. 1988
PubMed ID: 3136397
Activation of the polyomavirus enhancer by a murine activator protein 1 (AP1) homolog and two contiguous proteins.
Martin ME, Piette J, Yaniv M, Tang WJ, Folk WR
Proc Natl Acad Sci U S A. 1988
PubMed ID: 2842750
Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro.
Mermod N, Williams TJ, Tjian R
Nature. 1988
PubMed ID: 2833704
Localization of the human JUN protooncogene to chromosome region 1p31-32.
Haluska FG, Huebner K, Isobe M, Nishimura T, Croce CM, Vogt PK
Proc Natl Acad Sci U S A. 1988
PubMed ID: 3127828
A gene activated by growth factors is related to the oncogene v-jun.
Ryder K, Lau LF, Nathans D
Proc Natl Acad Sci U S A. 1988
PubMed ID: 3422745
Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1.
Bohmann D, Bos TJ, Admon A, Nishimura T, Vogt PK, Tjian R
Science. 1987
PubMed ID: 2825349

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	Human	Mouse	Rat
Entrez Gene	3725	16476	24516
Unigene	Hs.696684	Mm.275071	Rn.225373
Homologene	Hs.696684	Mm.275071	Rn.225373
OMIM	165160	N/A	N/A
GeneCards	JUN	N/A	N/A
Reactome	P05412	N/A	N/A
Plasma Peptide Atlas	ENSP00000314522	N/A	N/A
MGI	N/A	MGI:96646	N/A