Welcome to the PDDB - the Prion Disease Database

The Prion Disease Database (PDDB) is a public database that supports the prion disease research community by collecting, integrating, and presenting data from public sources and collaborating laboratories. The PDDB was originally created by the Institute for Systems Biology and the McLaughlin Research Institute, which have researched prion disease using a systems biology approach.

Currently, the database holds Affymetrix microarray data for a time-course study following five mouse strains and two different prion inoculations. The website also includes software tools for analyzing the data. In the future, we hope to expand the PDDB to include protein and expression profiling data from other laboratories. If you'd like to submit your data, click here.

If you use the PDDB in your work and/or publication(s), please cite:

N Gehlenborg, D Hwang, IY Lee, H Yoo, B Petritis, D Baxter, R Pitstick, B Marzolf, SJ DeArmond, GA Carlson and LE Hood, "The Prion Disease Database: A Comprehensive Transcriptome Resource for Systems Biology Research in Prion Diseases", Database 2009:bap011, 2009, doi:10.1093/database/bap011.

If you want to refer to our systems approach to prion disease, please cite:

D Hwang, IY Lee, H Yoo, N Gehlenborg, J Cho, B Petritis, D Baxter, R Pitstick, R Young, D Spicer, N Price, JG Hohmann, SJ DeArmond, GA Carlson and LE Hood, "Systems Approach to Prion Disease", Molecular Systems Biology 5:252, 2009, doi:10.1038/msb.2009.10.

The present version of the PDDB uses information from the following databases: Human NCBI35, Mouse NCBIM33, Rat RGSC3.1, dbSNP 125, Ensembl 35, EPConDB 3.41.